Test Price
2,800 AED✅ Home Collection Available
B-Cell Gene Rearrangement Detection (Clonality) Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل الكشف عن إعادة ترتيب جينات الخلايا البائية (اختبار النسيليّة) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ISO 9001:2015
Cert: INT/EGQ/2509DA/3139
DHA Licensed Facility 9834453
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑accredited PCR Fragment Analysis (BIOMED‑2 protocol).
- Premium Logistics: Paid Hospital‑Grade Home Collection with ISO Certified Cold‑Chain Transport (2–8°C) and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance for result interpretation by a specialist team.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
الملخص التنفيذي: نضمن دقة تشخيصية فائقة بنسبة 99.9% عبر مختبر معتمد ISO 9001:2015. خدمة سحب الدم المنزلي المبردة (2-8 درجة مئوية) ونقل العينات بسلسلة تبريد معتمدة، مع إرشادات طبية هاتفية ما بعد الفحص. التحقق من تغطية التأمين عبر واتساب على الرقم +971545488731.
Test Overview & Clinical Utility
B‑Cell Gene Rearrangement Detection (Clonality Assay) is a high‑precision molecular test that identifies monoclonal B‑cell populations by analysing immunoglobulin heavy chain (IGH) gene rearrangements using PCR and capillary electrophoresis fragment analysis. It is the gold‑standard for distinguishing malignant lymphoid proliferations (leukemia, lymphoma) from reactive lymphocytosis, and it aids in minimal residual disease monitoring.
| Feature | Our Test (ISO‑Certified) | Closest Alternative (Flow Cytometry Clonality) |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity (BIOMED‑2 multiplex PCR) | ~95‑98% sensitivity; limited by immunophenotypic overlap |
| Methodology | PCR Fragment Analysis (Capillary Electrophoresis) with GeneScan | Flow Cytometric light‑chain restriction analysis |
| Turnaround Time | 10–12 days (complete molecular report) | 3–5 days (screening only) |
* Comparators are based on standard clinical laboratory practices in the UAE region.
Physician Insight & Safety Protocol
“As a consultant hematologist, I understand the anxiety of waiting for a clonality report. This test provides vital molecular evidence to differentiate a benign reactive lymphocytosis from a potentially life‑threatening lymphoid malignancy. However, a positive result must always be interpreted alongside morphology, immunophenotyping, and clinical context to ensure an accurate diagnosis and tailored treatment.”
— Dr. Prabhakar Reddy, DHA License: 61713011
⚠ Medication Warning: Do not discontinue any prescribed medication without consulting your treating physician. This genetic test does not replace ongoing clinical care.
Exclusion Criteria & Emergency Red Flags
- Sample Rejection: Hemolyzed, clotted, frozen, or collected in a non‑EDTA tube. Insufficient volume (<2 mL) or missing mandatory Genomics Clinical Information Requisition Form (Form 20).
- ER Red Flags: Sudden high fever (>38.5°C), uncontrolled bleeding or bruising, severe bone pain, progressive neurological symptoms (confusion, seizures). These may indicate aggressive disease requiring urgent hematological intervention.
Patient FAQ & Clinical Guidance
1. What is the B‑Cell Gene Rearrangement Clonality Test?
Direct Answer: The B‑Cell Gene Rearrangement test detects monoclonal B‑cell populations by identifying identical immunoglobulin heavy chain gene rearrangements using PCR and capillary electrophoresis fragment analysis.
This highly sensitive molecular assay is essential for differentiating malignant lymphoproliferative disorders (such as leukemia and lymphoma) from benign, polyclonal B‑cell expansions seen in infections or autoimmune conditions. It can pinpoint even small clonal populations, guiding targeted therapy and monitoring response.
اختبار إعادة ترتيب جينات الخلايا البائية (اختبار النسيليّة) يكشف عن تجمعات الخلايا البائية الأحادية النسيلة عبر تحليل إعادة ترتيب جينات السلسلة الثقيلة للغلوبولين المناعي بواسطة تفاعل البوليميراز المتسلسل وتحليل الأجزاء. يُستخدم لتشخيص ومتابعة ابيضاضات الدم والأورام اللمفاوية.
2. How accurate is the test and what does a positive result mean?
Direct Answer: With 99.9% diagnostic sensitivity, a positive clonality result strongly suggests a clonal B‑cell disorder, but it must be correlated with clinical findings and additional laboratory studies.
A positive indicates the presence of a dominant B‑cell clone, which is characteristic of lymphoid malignancies like acute lymphoblastic leukemia (ICD‑10 C91.00) or mantle cell lymphoma (C83.10). Yet, rare benign clonal expansions can occur; therefore, a definitive diagnosis requires integration with blood counts, flow cytometry, and bone marrow biopsy.
تبلغ حساسية الاختبار التشخيصية 99.9%، والنتيجة الإيجابية تعني وجود نسيل خلايا بائية، مما يستدعي الربط مع الأعراض السريرية وفحوصات إضافية. لا تُشخّص النتيجة وحدها الورم الخبيث، ويجب تفسيرها من قبل أخصائي أمراض الدم.
3. What are the sample requirements and turnaround time?
Direct Answer: A 4 mL whole blood specimen collected in a Lavender‑top EDTA tube, shipped refrigerated (never frozen), yields final results within 10–12 days after laboratory receipt.
Accurate collection is critical: the sample must be kept at 2–8°C and accompanied by a fully completed Genomics Clinical Information Requisition Form (Form 20). Home collection by our VIP mobile phlebotomy team ensures correct handling and cold‑chain maintenance. Urgent preliminary results may be available on request.
يجب سحب 4 مل من الدم في أنبوب قمته خزامي (EDTA)، وحفظه مبرّداً دون تجميد. تظهر النتائج خلال 10–12 يوماً من استلام المختبر. يشترط استيفاء استمارة المعلومات الجينومية (نموذج 20). فريقنا المتنقل يضمن الجمع المنزلي المبرد.
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