Test Price
5,200 AED✅ Home Collection Available
CLL NGS Panel (FISH, Karyotyping, IGHV & TP53 Mutation Analysis) in UAE | 5200 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM daily).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The CLL NGS Panel is a definitive genomic stratification test for chronic lymphocytic leukemia, integrating karyotyping, FISH, PCR-based IGHV mutation analysis, and NGS for TP53. This single assay delivers the prognostic and predictive information required to personalise therapy according to international guidelines and DHA protocols.
| Feature | Our Test (CLL NGS Panel) | Standard FISH-Only Panel |
|---|---|---|
| Precision | 99.9% sensitivity for TP53 mutations (NGS depth >500x) | ~85% detection rate, low-level clones missed |
| Method | Karyotyping + FISH + PCR (IGHV) + NGS (TP53) | FISH probes only (13q, 11q, 17p, +12) |
| Turnaround Time | 3 weeks | 1–2 weeks |
Physician Insight & Safety Protocols
"CLL is a clinically heterogeneous malignancy where the mutational status of IGHV and TP53 defines both prognosis and therapeutic vulnerability. This integrated panel combines karyotyping, FISH, and high-sensitivity NGS to ensure no actionable mutation is overlooked, enabling your oncologist to craft a precisely tailored treatment plan. As with all laboratory tests, results must be interpreted within the full clinical context."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory & Safety Information
Exclusion Criteria & Safety Red Flags
- Pregnancy or suspected pregnancy (requires specialist referral).
- Active bleeding disorder or severe anaemia (Hb <7 g/dL) that contraindicates phlebotomy.
- Infection at the venipuncture site (cellulitis, abscess, or skin lesion).
- Inability to provide informed consent; for minors, additional guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ER Red Flags After Blood Draw: Rapid onset of dizziness, fainting, chest pain, shortness of breath, or uncontrolled bleeding from the puncture site – seek emergency care immediately.
- FFPE block submission requires a previously performed biopsy; no additional risk beyond the original procedure.
Medication Warning
⚠️ Do not discontinue prescribed medication without consulting your doctor.
Patient FAQ & Clinical Guidance
1. What is the CLL NGS Panel?
The CLL NGS Panel is a comprehensive genomic profiling that detects prognostic IGHV and TP53 mutations for personalised CLL management. It analyses peripheral blood or FFPE tissue using NGS and FISH to risk-stratify the leukemia and guide targeted therapy decisions.
2. How is the sample collected?
For peripheral blood, a trained phlebotomist visits your home via VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM). For FFPE tissue blocks, we arrange Secure Medical Courier Solid Tissue Specimen Retrieval. Both methods ensure sample integrity to our ISO-certified laboratory.
3. What do mutations in IGHV and TP53 mean for my treatment?
Mutated IGHV indicates a more indolent CLL course, whereas unmutated IGHV and TP53 mutations predict aggressive disease that may require targeted therapies. Detection of TP53 mutations helps oncologists select inhibitors or clinical trials, significantly improving outcomes.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: This service adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Laboratory processes are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) under MOHAP facility license 9834453. All clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | CLL NGS Panel (FISH, Karyotyping, IGHV & TP53 Mutation Analysis) |
| Price (AED) | 5,200 AED |
| Turnaround Time | 3 weeks |
| Sample Type / Matrix | Peripheral blood or FFPE tissue block |
| Methodology Used | Karyotyping + FISH + PCR (IGHV) + NGS (TP53) |
| ICD-10-CM Code | C91.1 |
| LOINC Code | 98196-9 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians