NCF4 Gene Full Gene NGS Test for Chronic Granulomatous Disease Type 5 (Cytochrome b-Positive, Autosomal Recessive) – Genetic Test in UAE

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited NGS Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM).
Clinical Guidance: Telephonic post-test genetic counseling by Consultant Medical Geneticist to interpret results.
Insurance: Direct Billing Verification – WhatsApp +971 54 548 8731.

Test Overview & Methodology

This next-generation sequencing (NGS) test comprehensively screens the NCF4 gene for mutations causing chronic granulomatous disease type 5, a rare primary immunodeficiency marked by recurrent bacterial and fungal infections. It is recommended for patients with unexplained abscesses, pneumonia, or inflammatory granulomas and a suspicion of cytochrome b-positive CGD.

Feature	Our Test (NCF4 Full Gene NGS)	Alternative (Targeted Mutation Panel)
Method	NGS with MLPA for copy number variants	PCR + Sanger sequencing of known mutations only
Diagnostic Sensitivity	99.9% for all pathogenic variants in NCF4	~60% (limited to common founder mutations)
Turnaround Time	3–4 Weeks	2 Weeks
Clinical Utility	Comprehensive, detects novel variants	Only detects pre-defined variants

Physician Insight & Safety Protocols

“Genetic results must be interpreted in conjunction with clinical phenotype and functional assays. A positive NCF4 mutation confirms diagnosis but does not predict disease severity; multidisciplinary care—including immunology and clinical genetics—is essential.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Important Advisory

Medication Warning:

Do not discontinue prescribed prophylactic antibiotics or antifungal therapy without consulting your doctor. Genetic testing does not replace ongoing clinical management.

Safety Exclusion Criteria & Emergency Red Flags

Exclusion Criteria: Patients unable to provide informed consent for genetic testing per Federal Decree-Law No. 4 of 2016 on Medical Liability; specimens not collected under standard venipuncture protocols; individuals under 18 years without parental/guardian consent.
Emergency Warning: If you experience high fever (>38.5°C), deep soft-tissue abscess, severe respiratory distress, or signs of sepsis, seek immediate emergency care irrespective of test status.

Patient FAQ & Clinical Guidance

1. What is the NCF4 gene test and who should get it?

Snippet: This NGS-based test detects mutations in the NCF4 gene causing chronic granulomatous disease type 5, suitable for individuals with recurrent unexplained bacterial/fungal infections.

The test analyses the entire coding region of NCF4 to identify pathogenic variants. It is indicated when clinical findings (e.g., recurrent skin abscesses, pneumonia, granulomas) and functional assays point to cytochrome b-positive CGD. Genetic counselling is provided to interpret results and guide family screening.

2. How is the sample collected and what is the turnaround time?

Snippet: A certified phlebotomist collects blood or buccal swab at your home using cold-chain protocols, with results returned in 3–4 weeks.

Home collection is performed between 8 AM and 11 PM by trained phlebotomists. Samples are transported in temperature-controlled containers to our ISO-certified laboratory. No fasting or medication adjustments are required for DNA testing.

3. Is this covered by insurance in the UAE?

Snippet: Most UAE health insurers reimburse medically necessary genetic testing for chronic granulomatous disease when pre-authorized; we verify your coverage instantly.

Direct billing is supported with major networks. Simply contact our support team via WhatsApp at +971 54 548 8731 with your insurance details, and we will confirm eligibility and handle pre-approval paperwork.

UAE Regulatory & Data Privacy Adherence

This test is performed under strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is handled confidentially and in accordance with UAE medical liability laws (Federal Decree-Law No. 4 of 2016). ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).

Clinical & Logistical Metadata

Test Name	NCF4 Gene Full Gene NGS Test for Chronic Granulomatous Disease Type 5
Price (AED)	2,800 AED
Turnaround Time	3–4 Weeks
Sample Type / Matrix	Blood or Buccal Swab (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available)
Methodology Used	Next-Generation Sequencing (NGS) with MLPA for Copy Number Variant Analysis
ICD-10-CM Code	D71
LOINC Code	91765-1
DHA Facility License & Laboratory Address	DHA Facility License No: 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE \| DNA Labs UAE