Test Price
700 AED✅ Home Collection Available
X and Y Chromosome Identification (FISH) in UAE | 700 AED | DHA-Certified Genetic Testing
Executive Summary & Core Metrics
This advanced fluorescence in-situ hybridization (FISH) assay detects X and Y chromosomes with a diagnostic sensitivity of 99.9% in peripheral blood, providing clinicians with rapid and accurate sex chromosome profiling for post-transplant chimerism monitoring, genetic identity verification, and forensic investigations. The test is performed under ISO 9001:2015 accredited protocols at DNA Labs UAE, a DHA-licensed facility.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited processing and internal quality controls.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. Hospital-grade specimen transport ensures sample integrity throughout the UAE.
- Clinical Guidance: Complimentary telephonic post-test result interpretation with a DHA-licensed Consultant Medical Genetics professional.
- Insurance & Billing: Direct billing verification and insurance pre-authorization assistance via WhatsApp: +971 54 548 8731.
- Turnaround Time: Results delivered within 3–4 business days from sample receipt at the laboratory.
Test Overview & Methodology
The X and Y Chromosome Identification (FISH) assay uses locus-specific fluorescent DNA probes that hybridize to target sequences on the X and Y chromosomes in interphase nuclei. This technique enables the direct visualization and enumeration of sex chromosomes in hundreds of cells within hours, providing a rapid and highly sensitive alternative to conventional karyotyping. The test is clinically indicated for monitoring donor chimerism in sex-mismatched allogeneic bone marrow transplant recipients, confirming chromosomal sex in cases of ambiguous genitalia or suspected sex chromosome disorders, and supporting forensic DNA identification workflows. Results are reported as the percentage of cells positive for X and/or Y chromosome signals, with a validated analytical sensitivity of 1% for minority cell populations. The assay is performed on peripheral blood collected in standard EDTA tubes, with no requirement for live or dividing cells, making it accessible for a wide range of clinical scenarios across the UAE.
Comparative Advantages Over Conventional Karyotyping
| Feature | X/Y Chromosome FISH | Conventional Karyotyping |
|---|---|---|
| Methodology | Fluorescence In-Situ Hybridization with targeted X and Y DNA probes | Giemsa-banded metaphase chromosome analysis |
| Analytical Sensitivity | Detects ≥1% X/Y cell population (chimerism detection threshold) | Requires ~5% aberrant clone for reliable detection |
| Turnaround Time | 3–4 business days | 10–14 business days |
| Cell Requirement | Interphase nuclei (no live cells required) | Metaphase spreads from cultured viable cells |
| Primary Clinical Applications | Post-transplant chimerism, rapid sex determination, forensic identification | Structural and numerical chromosomal aberrations, constitutional disorders |
Physician Insight & Safety Protocols
“The X and Y chromosome FISH assay delivers exceptionally rapid and sensitive quantification of sex chromosome content, making it an essential tool for monitoring donor engraftment after sex-mismatched allogeneic stem cell transplantation and for rapid genetic sex determination in forensic contexts. It is not, however, a standalone diagnostic for disorders of sex development; results must always be integrated with full clinical evaluation, hormonal profiling, and, when indicated, chromosomal microarray or whole exome sequencing. Patients should discuss any abnormal findings with their referring specialist before making medical decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Guidance for Patients and Clinicians
All genetic test results, including those from X/Y FISH analysis, should be interpreted by a qualified medical geneticist or specialist familiar with the clinical context. Please ensure that a valid physician prescription is provided at the time of sample collection, as required by DHA and MOHAP regulations. This test is optimized for use in post-transplant monitoring, forensic analysis, and rapid sex chromosome evaluation; it does not replace comprehensive cytogenetic or molecular genetic investigations when structural chromosomal abnormalities are suspected. For patients undergoing bone marrow transplant monitoring, serial testing is recommended at intervals determined by the transplant physician to track graft dynamics accurately.
Exclusion Criteria & Safety Considerations
- Do not discontinue any prescribed medication without explicit instruction from your treating physician.
- This test is not a substitute for emergency medical evaluation. If you experience acute symptoms such as unexplained bleeding, severe pain, or rapid health deterioration, seek immediate medical attention.
- Exclusion criteria: active severe infection, recent major surgery within two weeks, or inability to provide a peripheral blood sample.
- Samples must be collected in sterile EDTA tubes provided by the laboratory. Phlebotomy is performed by trained professionals under aseptic conditions.
- Results should be interpreted exclusively by a qualified specialist; self-interpretation may lead to misdiagnosis or inappropriate clinical action.
- A valid physician prescription is mandatory for all test requests, except for legally exempted cases such as court-ordered forensic investigations or specific public health directives.
Patient FAQ & Clinical Guidance
1. What is the X and Y Chromosome FISH test used for?
This test is primarily used to identify and quantify the presence of X and Y chromosomes in peripheral blood cells. Key clinical applications include monitoring donor chimerism after sex-mismatched bone marrow transplantation, confirming genetic sex in cases of ambiguous genitalia or suspected sex chromosome disorders, and supporting forensic human identification.
2. Can this test diagnose Turner syndrome or Klinefelter syndrome?
Yes, FISH can rapidly detect X monosomy (45,X) consistent with Turner syndrome and XXY (47,XXY) consistent with Klinefelter syndrome. However, a conventional karyotype or chromosomal microarray is recommended for comprehensive evaluation, as FISH does not detect structural rearrangements or low-level mosaicism. Always correlate findings with clinical assessment and hormonal workup.
3. Why do oncologists order X/Y FISH after an allogeneic stem cell transplant?
After a sex-mismatched transplant, the X/Y FISH test measures the proportion of donor versus recipient cells in the blood. This chimerism assessment is critical for predicting graft failure, detecting early relapse, and guiding immunosuppressive therapy. Serial testing allows the transplant team to track engraftment dynamics with high sensitivity.
4. Is a doctor prescription mandatory to book this test in the UAE?
Yes, a valid prescription from a DHA- or MOHAP-licensed physician is required for clinical testing. The prescription ensures appropriate clinical indication and facilitates accurate result interpretation. For court-ordered forensic investigations, a judicial authorization may be accepted in lieu of a physician order.
5. How should I prepare for the blood collection?
No special preparation such as fasting is required for this test. You may eat and drink normally before the blood draw. Please inform the phlebotomist if you are taking any anticoagulant medications. The sample is collected in a standard EDTA tube and must be transported to the laboratory at controlled temperature within 24 hours for optimal results.
UAE Regulatory & Data Privacy Adherence
Data Protection and Compliance Framework
All genetic testing services provided by DNA Labs UAE comply with the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and the Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. These regulations mandate strict confidentiality, encrypted data transmission, and explicit patient consent for any processing of genetic information. Clinical safety and patient consent protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring that all procedures, from phlebotomy to result delivery, adhere to the highest standards of medical accountability. The laboratory facility is licensed by the Dubai Health Authority (DHA) and the Ministry of Health and Prevention (MOHAP) and operates under ISO 9001:2015 certified quality management systems. No genetic data is shared with third parties without the patient's explicit written consent, and all records are retained in compliance with UAE federal data retention laws.
Clinical & Logistical Metadata
| Test Name | X and Y Chromosome Identification (FISH) |
| Price (AED) | 700 AED |
| Turnaround Time | 3–4 business days from sample receipt at laboratory |
| Sample Type / Matrix | Peripheral whole blood collected in EDTA tube; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) using locus-specific DNA probes for X and Y chromosomes on interphase nuclei |
| ICD-10-CM Code | Z13.79 (Encounter for genetic screening), Z31.5 (Encounter for genetic counseling and testing) |
| LOINC Code | 77683-8 (X and Y chromosome identification in Blood by FISH) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab Branding: DNA Labs UAE |
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