Test Price
1,200 AED✅ Home Collection Available
Chromosome Analysis of Products of Conception with Reflex FISH for Aneuploidy Detection in UAE
Executive Summary & Core Metrics
Clinical Excellence & Patient Convenience
- 99.9% Diagnostic Sensitivity – ISO 15189-accredited cytogenetics and molecular FISH analysis for definitive aneuploidy detection.
- Reflex FISH Safety Net: Automatic reflex to FISH for chromosomes 13, 16, 18, 21, 22, X, and Y when culture fails, ensuring a reportable result in >99% of cases.
- Hospital-Only Specimen Collection: Tissue extraction performed exclusively within accredited hospital facilities; mobile home phlebotomy is disabled for safety.
- Post-Test Genetic Guidance: Telephonic consult with a specialist genetic counsellor for clear result interpretation and reproductive planning.
- Insurance Concierge: Direct billing verification and pre-approval via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The Chromosome Analysis of Products of Conception (POC) with Reflex FISH identifies the most common chromosomal aneuploidies responsible for early pregnancy loss. The test begins with G‑banded karyotyping from cultured villous tissue, automatically advancing to Fluorescence In‑Situ Hybridization (FISH) for chromosomes 13, 16, 18, 21, 22, X, and Y when culture is unsuccessful or not feasible. This dual-methodology approach delivers clinically actionable results within 4–5 weeks, providing couples with essential genetic answers to guide informed reproductive decisions.
| Feature | DNA Labs UAE Reflex FISH Test | Standard Karyotype Only |
|---|---|---|
| Methodology | Tissue culture + G‑banded karyotype, automatic reflex to FISH (chromosomes 13, 16, 18, 21, 22, X, Y) | Culture + karyotype only; no FISH backup; repeat collection required if growth fails |
| Diagnostic Yield | >99% reportable rate (culture failure rescued by FISH reflex) | Up to 15% culture failure rate – no result possible |
| Turnaround Time | 4–5 weeks | 5–6 weeks (if repeat sampling is needed) |
| Price (AED) | 1,200 | 1,000 (no reflex, potential additional costs) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“This test provides couples who have experienced a miscarriage with a crucial piece of genetic information. The results can explain the underlying cause of the loss, but they must always be interpreted within the full clinical context and discussed with a qualified genetic counsellor. A normal karyotype does not exclude all genetic etiologies, and an abnormal finding should guide — not dictate — future family planning decisions. Our laboratory follows the highest standards of ISO 15189 to ensure accuracy and reliability.”
Medication & Clinical Advisory
Do not discontinue any prescribed medication or alter your treatment plan without consulting your doctor. This test is for diagnostic purposes only and should not replace ongoing medical supervision.
Exclusion Criteria & Specimen Requirements
- Formalin-fixed or otherwise preserved tissue is not accepted — only fresh curretted tissue in sterile normal saline is suitable.
- Whole fetus or fetal parts are not accepted; submit exclusively products of conception (villous material).
- Specimen must be shipped at 18–22°C and reach the reference laboratory within 24 hours of collection; failure to meet these conditions will result in sample rejection.
- A duly completed Chromosome & FISH Analysis Requisition Form (Form 17) is mandatory for processing.
- Emergency red flags: If you experience heavy bleeding, fever, or signs of infection after the procedure, seek immediate medical attention.
Patient FAQ & Clinical Guidance
1. What exactly does this test detect?
This test detects numerical chromosomal abnormalities (aneuploidies) in the lost pregnancy tissue that represent the most common genetic cause of early miscarriage. The karyotype examines all 46 chromosomes under the microscope, while reflex FISH rapidly screens for missing or extra copies of chromosomes 13, 16, 18, 21, 22, X, and Y — the ones most frequently implicated in pregnancy loss. Together, these methods provide a comprehensive genetic profile of the products of conception.
2. Why does the test take 4–5 weeks?
Culturing fetal cells to obtain sufficient metaphases for accurate chromosome analysis is a delicate process requiring up to three weeks. After culture, the harvested cells undergo G‑banding and a minimum of 20 metaphases are analyzed by certified cytogeneticists. If culture fails, the stored sample is reflexed to FISH, which adds several days but ensures a reportable result. Thorough quality control steps mandated by ISO 15189 justify this timeline.
3. Will my insurance cover this test?
Many UAE insurers cover medically indicated POC chromosome analysis. Our billing team verifies your policy and obtains pre-approval directly via WhatsApp. Send a copy of your insurance card and doctor’s referral to +971 54 548 8731 — we confirm coverage within 2 hours and guide you through the paperwork. Self-pay options are also available at 1,200 AED all-inclusive.
4. How should I prepare for specimen collection?
The specimen (fresh curretted villous tissue in sterile normal saline) is collected during a surgical procedure performed at an accredited hospital. No special preparation is needed from your side. The hospital staff will coordinate with our courier service to ensure the tissue reaches our laboratory within 24 hours at 18–22°C. Contact our team at +971 54 548 8731 for logistics assistance.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
- Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Operates under DHA Facility License No. 1143 and maintains ISO 15189 accreditation for medical laboratories.
Clinical & Logistical Metadata
| Test Name | Chromosome Analysis of Products of Conception with Reflex FISH for Aneuploidy Detection |
| Price (AED) | 1,200 |
| Turnaround Time | 4–5 Weeks |
| Sample Type / Matrix | Products of Conception (POC) – Fresh Curretted Villous Tissue in Sterile Normal Saline Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. |
| Methodology Used | G‑banded Karyotyping with Reflex FISH (Chromosomes 13, 16, 18, 21, 22, X, Y) |
| ICD-10-CM Code | O03.9 (Spontaneous Abortion), O02.1 (Missed Abortion) |
| LOINC Code | 69181-3 |
| DHA Facility License & Laboratory Address Invariants | License No. 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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