Test Price
2,800 AED✅ Home Collection Available
PRX Gene CMT4F Genetic Test in UAE | 2800 AED | DHA Licensed Molecular Diagnostics
Executive Summary & Core Metrics
- ✓99.9% Diagnostic Sensitivity via ISO 15189–aligned bioinformatics pipeline and deep NGS coverage of the entire PRX gene, validated against UAE reference standards.
- ✓VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection — ISO‑certified logistics, available daily from 8 AM to 11 PM, ensuring sample integrity from your doorstep.
- ✓Post‑Test Clinical Tele‑Guidance — a genetics‑trained physician explains your results and next steps in a dedicated tele‑consultation.
- ✓Insurance Direct Billing Verification — send your policy via WhatsApp +971 54 548 8731 for instant eligibility confirmation.
Legal Compliance: Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) · Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. DHA Facility License 1143. ISO 9001:2015 Cert: INT/EGQ/2509DA/3139.
Test Overview & Methodology
This next‑generation sequencing (NGS) test examines the full coding region and exon‑intron boundaries of the PRX (periaxin) gene to detect pathogenic variants responsible for Charcot‑Marie‑Tooth disease type 4F (CMT4F) — a severe, early‑onset autosomal recessive neuropathy. Deep coverage enables concurrent detection of single‑nucleotide variants, small insertions/deletions, and copy‑number variations across the entire gene locus.
| Test Feature | Our PRX NGS Test (ISO Accredited) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Methodology | Full‑gene NGS with >100× mean depth; CNV detection | Targeted Sanger sequencing of previously described hotspots only |
| Variant Detection Rate | >99.5% of clinically relevant SNVs & small indels; detects large deletions/duplications | ~85% (misses deep intronic, regulatory, and CNV variants) |
| Turnaround Time | 3–4 weeks (expedited reporting for urgent cases) | 4–6 weeks |
| Sample Types Accepted | Whole blood, extracted DNA, or one drop blood on FTA card | Whole blood only |
| Accreditation | ISO 9001:2015 · DHA/MOHAP Licensed | May vary; not always ISO‑certified |
Physician Insight & Safety Protocols
“A molecular diagnosis of CMT4F through comprehensive PRX gene sequencing provides families with definitive answers that guide rehabilitation, surveillance, and reproductive planning. This NGS platform delivers the resolution needed to detect the full spectrum of pathogenic variants. Patients and referring physicians should always pair genetic results with a complete neurological assessment and post‑test genetic counselling to ensure informed decision‑making. Our team is dedicated to supporting you through every phase of this diagnostic journey.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics · DHA Registration ID: 9294403
Treatment Continuity Advisory
Do not alter or discontinue any prescribed medication, physiotherapy regimen, or supportive therapy without consulting your treating neurologist. This genetic test is a diagnostic aid and does not replace ongoing clinical management or emergency neurological care.
Exclusion Criteria & Emergency Red Flags
- Exclusion: No documented genetic counselling session prior to sample collection; inability to provide informed consent; acute psychiatric instability that may compromise comprehension of genetic results.
- Red Flags: If you experience sudden severe muscle weakness, difficulty breathing, or loss of mobility before or after sample collection, proceed to the nearest Emergency Department and inform the testing coordinator immediately.
Patient FAQ & Clinical Guidance
1. What is the PRX gene and how does it relate to CMT4F?
Direct answer: The PRX gene encodes periaxin, a protein essential for myelin sheath maintenance; pathogenic mutations cause severe, early‑onset CMT4F neuropathy with motor and sensory deficits. This test confirms the diagnosis and guides therapy, surveillance, and family counselling.
2. How accurate is the NGS test for PRX mutations?
Direct answer: Our ISO‑accredited NGS achieves 99.9% diagnostic sensitivity by sequencing the complete PRX gene with deep coverage, including regions missed by older methods. The analysis pipeline is validated against international reference standards and reviewed by a consultant clinical geneticist.
3. What preparation is required before giving the sample?
Direct answer: A mandatory genetic counselling session must be completed prior to collection; no fasting is needed. You should provide a detailed three‑generation family history pedigree. Accepted samples include whole blood, extracted DNA, or a single blood spot on an FTA card.
4. When will I receive my results and how are they delivered?
Direct answer: Results are typically available within 3–4 weeks. Urgent cases can be expedited upon request. A secure digital report is delivered via encrypted email or patient portal, followed by a tele‑consultation with a genetics specialist to interpret the findings.
5. Does insurance cover this genetic test?
Direct answer: Coverage varies by insurer and policy. You can send your insurance details via WhatsApp +971 54 548 8731 for a complimentary direct billing eligibility check before booking your collection.
Licensed phlebotomist · 8 AM – 11 PM daily · +971 54 548 8731
UAE Regulatory & Data Privacy Adherence
All genetic data generated by this test is processed and stored in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. Your genetic information is encrypted, access‑controlled, and never shared with third parties without your explicit written consent.
DNA Labs UAE operates under DHA Facility License 1143 at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. We maintain ISO 9001:2015 certification (INT/EGQ/2509DA/3139) and participate in external quality assessment schemes aligned with international molecular genetics standards.
Clinical & Logistical Metadata
| Test Name | PRX Gene (Periaxin) NGS Sequencing – CMT4F |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks (Expedited Reporting Available for Urgent Cases) |
| Sample Type / Matrix | Whole Blood · Extracted DNA · FTA Card |
| Methodology Used | Next‑Generation Sequencing (NGS) – Full‑Gene Coverage with CNV Detection |
| ICD-10-CM Code | G60.0 |
| LOINC Code | 94233-7 |
| DHA Facility License & Laboratory Address | License No. 1143 · Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians