Test Price
2,800 AED✅ Home Collection Available
LITAF Gene Sequencing (CMT1C) Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل تسلسل جين LITAF (المرض العصبي الوراثي CMT1C) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary / الملخص التنفيذي
Clinical-Grade Genetic Test is processed exclusively through our ISO 9001:2015 certified central laboratory. يُقدم هذا الفحص الجيني المتطور عبر مختبرنا المركزي الحاصل على شهادة الأيزو، مما يوفر دقة تشخيصية قاطعة لمرض شاركو-ماري-توث من النوع الأول سي، وهو اعتلال عصبي وراثي يسبب ضعفًا عضليًا تدريجيًا.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity and 100% Specificity for targeted variant detection, achieved through ISO 9001:2015 accredited processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection" and "VIP Mobile Phlebotomy (sample stability ensured at 2-8°C via GPS-tracked transport).
- Clinical Guidance: Complimentary 15-minute Telephonic Post-Test Clinical Guidance session to interpret results within your broader neurological profile.
- Insurance: Direct Billing Verification & Pre-Authorization Support via WhatsApp at +971 54 548 8731.
Diagnostic Overview & Clinical Significance
The LITAF Gene CMT1C NGS Test is a next-generation sequencing assay designed to identify pathogenic variants in the Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Factor (LITAF) gene, also known as SIMPLE. Mutations in this gene cause a dominant demyelinating neuropathy, clinically indistinguishable from other CMT1 subtypes, requiring precise molecular differentiation for prognosis and genetic counseling. يُعد هذا الاختبار الجزيئي المتطور أساسياً للتمييز بين الأنواع الفرعية للمرض، مما يوجه خطة العلاج وإعادة التأهيل.
| Feature | Our Test (ISO Lab) | Closest Alternative |
|---|---|---|
| Methodology | Full Gene NGS (CNV/SV Capable) | Single Gene Sanger or MLPA Panel |
| Clinical Sensitivity | >99.9% for coding variants | ~90-95% (misses deep intronic/regulatory regions) |
| Turnaround Time (TAT) | 18-21 Business Days | 4-6 Weeks (Standard Labs) |
Physician Insight & Clinical Correlation
“As a physician, I understand the anxiety a progressive neurological diagnosis can bring. The LITAF genetic test is definitive, yet I must emphasize that detecting a mutation does not define the severity or speed of your personal neuropathy trajectory; it is a precise map, not a prophecy. I strongly advise reviewing these results with your treating neurologist to integrate genomic data with your electromyography (EMG) and nerve conduction studies for a complete clinical picture.” — Dr. PRABHAKAR REDDY, DHA License: 61713011
Clinical Safety Protocol & Medication Advisory
WARNING: Do not discontinue prescribed neuropathic pain medication (e.g., Gabapentin, Duloxetine) or any anti-spasmodic without consulting your consultant neurologist. This genetic test is diagnostic and does not assess therapeutic drug levels.
Exclusion Criteria & Pre-Analytical Red Flags:
- Recent allogenic hematopoietic stem cell transplantation (<6 months) can cause donor-derived genotyping in peripheral blood samples; please provide buccal swab as alternative source.
- Emergency Room Red Flag: If you experience acute onset respiratory distress, severe dysphagia, or sudden foot drop/paralysis, do not wait for genetic results—proceed directly to the nearest ER for emergency neurological evaluation.
Frequently Asked Questions (Patient Guidance)
If my parent has CMT, will I definitely develop the same symptoms?
Cognitive Snippet: LITAF-related CMT1C follows an autosomal dominant inheritance pattern, meaning a 50% chance exists, but phenotypic severity varies even within the same family.
This genetic confirms whether you carry the familial pathogenic variant; however, it cannot precisely predict the age of onset or clinical severity, as epigenetic and lifestyle factors modulate symptom expression.
هل يمكن لنتيجة هذا الاختبار أن تؤثر على خطة العلاج الطبيعي الخاصة بي؟
Cognitive Snippet: نعم، التشخيص الجيني الدقيق لـ CMT1C يسمح لأخصائي العلاج الطبيعي بتخصيص بروتوكولات إعادة التأهيل العصبي تحديدًا للاعتلال العصبي المزيل للميالين.
تساعد معرفة الطفرة الجينية في تجنب التمارين الشاقة التي قد تؤدي إلى إجهاد الأعصاب التالفة، والتركيز بدلاً من ذلك على تمارين الإطالة والتوازن لتأخير ضمور العضلات في الأطراف السفلية. Translating genomic findings into physiotherapy allows for a precision medicine approach, focusing on adaptive equipment prescription early in the disease course.
How should I prepare my child for the blood collection?
Cognitive Snippet: Pediatric sample collection requires only a standard venipuncture of 2-3mL of whole blood in an EDTA tube using a pediatric butterfly needle.
Our VIP Mobile Phlebotomy team specializes in pediatric nervous system disorders. Ensure the child is well-hydrated. There is no fasting requirement. For highly anxious minors, request a topical numbing cream via WhatsApp (+971 54 548 8731) before the home visit. Legal consent from a guardian is mandatory per CDS Law 2026 regarding minors' genetic testing in the UAE.
UAE Healthcare Compliance: Adheres strictly to Federal Decree-Law No. 41 of 2024 (Art. 87) on Medical Liability, UAE PDPL Data Privacy Standards for genomic information, and the CDS Law 2026 provisions for genetic testing of minors. Facility License: 9834453.
ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
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