Test Price
2,800 AED✅ Home Collection Available
GJB1 Gene (Dejerine-Sottas Disease) Next-Generation Sequencing Genetic Test in UAE
2800 AED | 2026 DHA Guidelines
تحليل جين GJB1 لمرض ديجيرين-سوتاس في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing
- ✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
- ✓ ضمان الدقة 99.9% عبر مختبر معتمد آيزو 9001:2015
Overview of GJB1 Gene (Dejerine-Sottas Disease) NGS Test
This next-generation sequencing test analyses the entire coding region of the GJB1 gene to identify pathogenic variants causing Dejerine-Sottas disease, a severe early-onset hereditary peripheral neuropathy. يُستخدم هذا التحليل لتأكيد التشخيص الجيني وتوجيه الإدارة الطبية والتخطيط الأسري للمصابين. Early molecular confirmation enables personalised neurological care and informed family decisions.
| Feature | Our Test (DHA-Licensed) | Closest Alternative (External Panel) |
|---|---|---|
| Methodology | NGS full gene sequencing | Targeted mutation analysis / limited panel |
| Sensitivity | 99.9% (including deep intronic variants) | ~85% (misses novel/rare variants) |
| Turnaround | 4 – 5 weeks | 6 – 8 weeks |
| Regulatory | DHA / MOHAP compliant, ISO 9001:2015 | Variable |
Physician Insight & Safety Protocol
From Dr. PRABHAKAR REDDY (DHA: 61713011): “Genetic testing for Dejerine-Sottas disease provides clarity in a condition often mistaken for other neuromuscular disorders. Our results integrate comprehensive clinical correlation so that each family receives a roadmap — not just a raw data dump. You are not alone in this journey; our multidisciplinary team supports you from sample collection to interpretation.”
⚠️ Medication Warning:
Do not discontinue prescribed medication without consulting your doctor. Genetic test results should always be discussed with your treating neurologist before any change in therapy.
Safety Exclusion Criteria & ER Red Flags
Home Collection Exclusion:
- Uncontrolled bleeding disorder or therapeutic anticoagulation
- Active severe skin infection at puncture site
- Acute febrile illness > 38.5°C
- Patient unable to provide informed consent (for minors, guardian + CDS Law 2026 compliant)
Seek Emergency Care if:
- Sudden worsening of limb weakness or gait instability
- Respiratory difficulty or chest infection symptoms
- Severe, unexplained pain or autonomic dysfunction
- Loss of consciousness
Patient FAQ & Clinical Guidance
1. What is the GJB1 gene and how does it relate to Dejerine-Sottas disease?
Key Insight: A GJB1 gene mutation leads to connexin 32 deficiency, disrupting myelin in peripheral nerves and causing progressive neuropathy. This test identifies disease-causing variants, enabling definitive diagnosis and differentiation from other Charcot-Marie-Tooth subtypes.
تؤدي طفرات جين GJB1 إلى نقص بروتين كونيكسين 32 الضروري لصيانة الميالين، مما يسبب اعتلالاً عصبياً وراثياً تدريجياً. يكشف هذا الفحص عن التغيرات الجينية المسببة للمرض.
2. How accurate is this NGS test for Dejerine-Sottas disease compared to older methods?
Key Insight: With 99.9% analytical sensitivity, our NGS approach detects >99% of known GJB1 mutations and many deep intronic variants missed by single-gene Sanger sequencing. A negative result therefore significantly reduces the likelihood of GJB1-related disease, narrowing the diagnostic path.
بدقة تحليلية تبلغ 99.9%، يكتشف تسلسل الجيل التالي أكثر من 99% من طفرات جين GJB1 المعروفة، مما يجعله المعيار الذهبي للتشخيص الجزيئي.
3. What do I need to do before the blood draw and will insurance cover the cost?
Key Insight: A genetic counselling session to draw a detailed pedigree is highly recommended prior to testing; this forms part of our pre- service. Most UAE insurers cover medically necessary carrier/pre-symptomatic testing for hereditary neuropathies—our team verifies your policy via WhatsApp before collection.
يُوصى بجلسة استشارة وراثية لتوثيق شجرة العائلة قبل الفحص؛ ويتحقق فريقنا من تغطية التأمين الصحي قبل إجراء الفحص.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians