Test Price
2,800 AED✅ Home Collection Available
FGD4 Gene CMT4H Genetic Test – Hereditary Neuropathy Diagnosis in Dubai
Executive Summary & Core Metrics
This targeted next-generation sequencing assay identifies pathogenic variants in the FGD4 gene, delivering a definitive molecular diagnosis for autosomal recessive Charcot-Marie-Tooth disease type 4H (CMT4H) in compliance with Dubai Health Authority and UAE regulatory standards. The test provides unmatched precision for clinicians evaluating inherited neuropathies.
- Diagnostic Sensitivity: >99.9% via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection, available daily 8 AM – 11 PM across all Emirates.
- Clinical Guidance: Post-test telephonic interpretation by a Consultant Medical Genetics specialist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The FGD4 Gene CMT4H Genetic Test employs targeted next-generation sequencing (NGS) to provide comprehensive coverage of all coding exons and flanking intronic regions of the FGD4 gene. This approach delivers high analytical sensitivity for single-nucleotide variants, insertions, deletions, and copy-number alterations associated with CMT4H, enabling a conclusive diagnosis for patients presenting with distal muscle weakness, sensory loss, and foot deformities suggestive of an inherited neuropathy.
| Feature | FGD4 Targeted NGS | Whole Exome Sequencing |
|---|---|---|
| Methodology | Targeted NGS – full FGD4 exon and flanking region coverage | Whole Exome Sequencing – broader scope, lower depth per gene |
| Analytical Sensitivity | >99.9% for FGD4 variants | 95–98% for FGD4 exons at standard coverage |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Cost | 2,800 AED | 5,000–7,000 AED |
Physician Insight & Safety Protocols
“When a patient presents with distal weakness, sensory loss, and a family history consistent with autosomal recessive inheritance, the FGD4 targeted NGS test provides a definitive molecular diagnosis for CMT4H with exceptional accuracy. A negative result does not exclude other hereditary neuropathies or acquired causes, so careful clinical correlation and, if indicated, broader genomic testing remain essential in the diagnostic workup.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory Information for Patients
We understand that waiting for genetic results can be a stressful period. This test is designed to provide clarity for you and your healthcare team. Your sample will be handled with the highest standards of privacy and quality. Please continue all prescribed treatments and therapies unless your doctor advises otherwise, and do not hesitate to reach out to our team if you have any questions before or after the test.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients with acute bleeding disorders or those on high-dose anticoagulants must inform the phlebotomist before sample collection.
- Red Flag: Seek emergency care immediately if you experience rapidly progressive muscle weakness, difficulty breathing, or difficulty swallowing.
- Red Flag: Sudden loss of balance, vision changes, or severe headache may indicate an unrelated neurological emergency — call 998 without delay.
- Pre-test requirement: A detailed clinical history and formal genetic counselling session with pedigree analysis are mandatory before testing.
Patient FAQ & Clinical Guidance
1. What is the FGD4 Gene CMT4H Genetic Test?
This targeted next-generation sequencing test analyzes the FGD4 gene for disease-causing mutations that cause Charcot-Marie-Tooth disease type 4H, a rare inherited neuropathy affecting peripheral nerves. The test provides a definitive molecular diagnosis to guide clinical management and family counselling.
2. How is the sample collected for this genetic test?
A standard peripheral whole blood sample (3–5 mL in an EDTA tube) is collected by a trained phlebotomist. Through our VIP mobile phlebotomy service, a certified nurse visits your home across all Emirates between 8 AM and 11 PM, using temperature-controlled cold-chain transport to ensure sample integrity.
3. How long does it take to receive results?
Results are typically delivered within three to four weeks from the date your sample arrives at our ISO 9001:2015 accredited laboratory. This timeline allows for rigorous quality control, bioinformatics analysis, and clinical interpretation by our Consultant Medical Genetics specialist.
4. What does a positive result mean for my treatment?
A positive result confirming a pathogenic FGD4 variant enables your neurologist to establish a precise diagnosis of CMT4H, tailor symptomatic management, and provide accurate recurrence risk information for family planning. It also avoids the need for further unnecessary diagnostic procedures and guides appropriate physical therapy and orthotic interventions.
5. Is home sample collection available in the UAE?
Yes, our VIP mobile phlebotomy service operates across all seven Emirates from 8 AM to 11 PM daily. Samples are collected using hospital-grade sterile techniques and transported under continuous temperature monitoring in ISO-certified cold-chain packaging to guarantee specimen quality from your doorstep to the laboratory.
UAE Regulatory & Data Privacy Adherence
Your genetic data is protected under the UAE’s comprehensive legal framework for health information and personal data. This test and all associated data handling comply with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — governing the collection, processing, and storage of your personal and genetic information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — regulating the security and confidentiality of electronic health records and diagnostic data.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — ensuring clinical safety standards and informed consent protocols throughout the testing pathway.
All samples are processed at our DHA-licensed facility under strict access controls, encryption standards, and anonymization procedures to safeguard your privacy.
Clinical & Logistical Metadata
| Test Name | FGD4 Gene CMT4H Genetic Test – Targeted NGS |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM – 11 PM) |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) – full FGD4 exon and flanking region coverage |
| ICD-10-CM Code | G60.0 |
| LOINC Code | 21656-9 |
| DHA Facility License & Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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