Test Price
2,800 AED✅ Home Collection Available
TGFB3 Gene Arrhythmogenic Right Ventricular Cardiomyopathy Type 1 Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Diagnostic Precision: 99.9% sensitivity via ISO 9001:2015 accredited Next-Generation Sequencing (NGS) workflow.
- Premium Logistics: VIP mobile phlebotomy with ISO-certified temperature-controlled cold-chain home collection, available daily 8 AM – 11 PM.
- Clinical Follow-Through: Telephonic post-result counselling with a Consultant Medical Genetics to interpret findings in context of family and cardiac history.
- Insurance Facilitation: Real-time coverage verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This molecular diagnostic assay targets the TGFB3 gene to confirm or exclude Arrhythmogenic Right Ventricular Cardiomyopathy Type 1 (ARVC1), an inherited cardiac muscle disorder associated with ventricular arrhythmias and sudden cardiac arrest. The test employs next-generation sequencing to detect single-nucleotide variants, small insertions or deletions, and exon-level copy number changes across the entire coding region and flanking intronic boundaries.
All variants are classified according to American College of Medical Genetics and Genomics (ACMG) guidelines, and results are delivered with a comprehensive clinical interpretation. Cascade screening for at-risk family members is recommended when a pathogenic or likely pathogenic variant is identified.
Why Our Test Leads the Market
| Feature | Our TGFB3 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% sensitivity; covers entire coding region ±20 bp intronic flanks | Lower resolution; may miss deep intronic variants |
| Methodology | NGS with bioinformatic ACMG classification | Capillary sequencing, limited throughput |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Sample Options | Whole Blood, Extracted DNA, Dried Blood Spot (FTA Card) | Limited to high-quality DNA |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“A pathogenic TGFB3 variant is a strong risk marker for ARVC Type 1, but the diagnosis must integrate cardiac imaging, 12-lead ECG, Holter monitoring, and detailed family pedigree analysis. A negative sequencing result does not eliminate clinical suspicion—other genes and environmental modifiers may contribute. I emphasise to every patient that this genetic test is a critical component of a comprehensive cardiogenetic workup, never a standalone diagnostic verdict.”
Medication Advisory
⚠️ Do not discontinue any prescribed antiarrhythmic, beta-blocker, or anticoagulant medication without consulting your treating cardiologist. This test is for diagnostic clarification and does not replace urgent clinical evaluation.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent; active febrile illness (defer collection); hemoglobin below 7 g/dL for venipuncture.
- Emergency Red Flags: New-onset chest pain, unexplained syncope, or sustained palpitations—seek immediate emergency care. This test is not intended for acute diagnostic triage.
Patient FAQ & Clinical Guidance
1. How does the TGFB3 NGS test confirm ARVC Type 1?
Our NGS platform sequences the entire TGFB3 gene with deep coverage, identifying single-nucleotide variants, small insertions or deletions, and exon-level copy number changes linked to ARVC1. Variants are classified per ACMG guidelines, and only clinically actionable findings are reported. A pathogenic or likely pathogenic result, when correlated with cardiac imaging and electrocardiographic criteria, substantiates the diagnosis and enables targeted cascade screening for first-degree relatives.
2. What should I expect during the home blood collection?
A certified phlebotomist arrives with an ISO-compliant temperature-controlled transport container, draws a single 4 mL EDTA blood sample in approximately 15 minutes, and initiates the validated cold chain to our laboratory. If venipuncture is not feasible, a dried blood spot on FTA card may be used. Your sample is anonymised at the point of collection in compliance with UAE PDPL standards. Results are delivered electronically within 3–4 weeks, followed by a scheduled telephonic consultation with our Consultant Medical Genetics.
3. Is this test covered by UAE health insurance?
Many UAE insurers now reimburse genetic testing for hereditary cardiomyopathies when prior authorization is secured and a cardiologist referral is provided. Our team facilitates direct billing verification via WhatsApp at +971 54 548 8731—send a clear photo of your insurance card and Emirates ID. We will confirm coverage within two hours and guide you on the necessary referral documentation to maximise your reimbursement.
UAE Regulatory & Data Privacy Adherence
This test is performed under the governance of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols align with Federal Decree-Law No. 4 of 2016 on Medical Liability. All laboratory procedures are ISO 9001:2015 certified (Cert. INT/EGQ/2509DA/3139), and results are transmitted through encrypted channels with strict access controls.
Clinical & Logistical Metadata
| Test Name | TGFB3 Gene Arrhythmogenic Right Ventricular Cardiomyopathy Type 1 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with ACMG variant classification |
| ICD-10-CM Code | I42.8 |
| LOINC Code | 55233-1 |
| DHA Facility License & Laboratory Address | DHA License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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