Test Price
2,800 AEDโ Home Collection Available
RYR2 Gene Genetic Test for Arrhythmogenic Right Ventricular Dysplasia Type 2 in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain and VIP Mobile Phlebotomy (available daily 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in Result Interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- DHA Licensed Facility: License No. 1143, Dubai Healthcare City.
Test Overview & Methodology
The RYR2 gene test using Next-Generation Sequencing (NGS) identifies pathogenic variants linked to Arrhythmogenic Right Ventricular Dysplasia Type 2 (ARVD2), a heritable cardiomyopathy causing life-threatening ventricular arrhythmias. This comprehensive analysis supports early detection, family cascade screening, and personalised cardiac risk management. Full gene coverage includes all coding regions and ยฑ20 bp splice sites, enabling detection of single nucleotide variants (SNVs), insertions/deletions (indels), and copy number variants (CNVs) with MLPA confirmation.
| Test Parameter | Our RYR2 NGS Test | Standard Sanger Sequencing |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) | Sanger Sequencing |
| Coverage | Full gene (coding regions ยฑ20 bp splice sites) | Selected exons only |
| Variant Detection | SNVs, Indels, CNVs (MLPA confirmation) | SNVs and small indels |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Clinical Reporting | DHA compliant, ACMG pathogenicity classification | Basic variant description |
Physician Insight & Safety Protocols
โThe RYR2 gene plays a central role in cardiac calcium homeostasis. Pathogenic variants increase the risk of exercise-induced arrhythmias and sudden cardiac arrest. This NGS-based test provides the granularity needed for precise risk stratification and enables family members to make informed decisions about their own cardiac health. Clinical correlation with imaging and electrocardiographic findings remains essential for comprehensive management.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do not discontinue, alter, or adjust any prescribed antiarrhythmic or cardiovascular medication without explicit consultation with your treating physician. Abrupt changes may increase the risk of arrhythmic events.
Exclusion Criteria & Emergency Red Flags
- Unstable cardiovascular condition requiring immediate medical attention.
- Inability to provide informed consent.
- Minors without legal guardian consent per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Recent blood transfusion (within 4 weeks) that may affect DNA analysis.
Emergency Red Flags: Severe chest pain, syncope (fainting), palpitations with dizziness, or sudden shortness of breath โ seek emergency care immediately. Do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the clinical significance of detecting RYR2 mutations?
Key Insight: RYR2 gene mutations cause calcium-handling defects in cardiac muscle, predisposing to life-threatening ventricular arrhythmias and ARVD type 2. Detecting them enables early risk stratification, family cascade testing, and tailored preventive strategies to reduce sudden cardiac death risk.
2. How is the sample collected and what is the turnaround time?
Key Insight: A simple blood draw or extracted DNA sample is collected by our DHA licensed phlebotomists during a home visit via VIP Mobile Phlebotomy with temperature-controlled cold-chain transport. Results are delivered within 3 to 4 weeks from sample receipt at our genomics laboratory.
3. Is my genetic data protected under UAE law?
Key Insight: Yes โ your genomic information is safeguarded under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your data cannot be shared or used without your explicit, informed consent.
4. Will a positive result mean I will develop symptoms?
Key Insight: Not necessarily. A pathogenic RYR2 variant indicates increased susceptibility but does not guarantee symptom development. Penetrance is variable and influenced by genetic modifiers, lifestyle, and environmental factors. Regular cardiology follow-up and family screening are recommended.
5. Can this test be performed on children?
Key Insight: Yes, but only with informed consent from a parent or legal guardian in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. Pre-test genetic counselling is mandatory for minors to ensure that families understand the implications of results.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Patient Data Protection
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ governs the collection, processing, and storage of genetic and health data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ regulates digital health records and telemedicine.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ establishes legal frameworks for informed consent and clinical safety.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) โ quality management system for laboratory processes.
- DHA Facility License No. 1143 โ accredited diagnostic facility in Dubai Healthcare City.
Clinical & Logistical Metadata
| Test Name | RYR2 Gene Genetic Test for Arrhythmogenic Right Ventricular Dysplasia Type 2 |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Extracted DNA (FTA card acceptable). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) with MLPA confirmation for CNV detection |
| ICD-10-CM Code | I42.8, I47.2, Z15.89 |
| LOINC Code | 69548-6 |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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