Test Price
2,800 AED✅ Home Collection Available
PPP1R8 Gene Cardiac Defects Genetic Test – 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Precision Genetic Screening for Inherited Cardiac Conditions
This targeted next-generation sequencing (NGS) test analyzes the PPP1R8 gene to identify pathogenic variants associated with cardiomyopathies and congenital heart defects. With 99.9% diagnostic sensitivity, ISO-accredited processing, and comprehensive pre- and post-test genetic counselling, this test enables accurate risk stratification for patients with a family history of sudden cardiac death or structural heart abnormalities.
- Methodology: Targeted NGS with >100x mean read depth
- Turnaround Time: 3–4 Weeks
- Sample: Peripheral whole blood (VIP home phlebotomy available)
- Accreditation: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139)
Test Overview & Methodology
The PPP1R8 gene sequencing test employs next-generation sequencing to examine the entire coding region, detecting single nucleotide variants (SNVs), small insertions/deletions (indels), and copy number variants (CNVs) with high sensitivity. This targeted approach provides definitive molecular diagnosis for inherited cardiomyopathies, enabling personalized clinical management and family screening.
| Feature | Our Test (Precision) | Closest Alternative (Panel/Exome) |
|---|---|---|
| Methodology | Targeted NGS with >100x Mean Read Depth | Broad Panel or Whole Exome with lower depth |
| Variant Detection | SNVs, Indels, and Copy Number Variants (CNVs) | Often misses CNVs or requires separate assay |
| Turnaround Time | 3 to 4 Weeks | 6 to 12 Weeks (common for exomes) |
Physician Insight & Safety Protocols
"As a Consultant Medical Geneticist, I emphasize that genetic testing for cardiac disorders requires careful pre-test counselling and pedigree analysis. The PPP1R8 gene NGS test provides high-resolution data, but results must be interpreted in the context of the patient's full clinical history and family structure. A negative result does not exclude all genetic causes, and ongoing cardiac surveillance may remain necessary."
— Dr. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Medication Advisory
Do not alter or discontinue any prescribed cardiac medications, including beta-blockers or anti-arrhythmics, without explicit consultation with your treating physician. This genetic test is a diagnostic tool and does not replace ongoing medical management.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: This test is not indicated for asymptomatic minors under 12 years without a documented clinical indication, in line with pediatric genetic testing guidelines.
- Exclusion: Patients experiencing acute psychiatric distress directly related to genetic testing anxiety should be stabilized before proceeding.
- Emergency Warning: If you experience sudden chest pain, severe dyspnea, syncope, or palpitations while awaiting results, seek immediate emergency medical care.
Patient FAQ & Clinical Guidance
1. What is the purpose of the PPP1R8 gene test?
This test sequences the PPP1R8 gene to identify pathogenic variants that can cause inherited cardiomyopathies and congenital heart defects. It enables precise diagnosis, risk stratification for family members, and personalized clinical management.
2. What preparation is required before the test?
A mandatory pre-test genetic counselling session is required to construct a detailed family pedigree covering all relatives with known cardiac conditions. This step is essential for accurate variant interpretation and aligns with UAE data privacy standards (PDPL).
3. How long will results take, and who will explain them?
The turnaround time is 3 to 4 weeks from sample receipt. You will receive a comprehensive PDF report followed by a telephonic post-test guidance session with a certified genetic counsellor to explain findings and implications.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
This genetic test is performed under the regulatory oversight of the Dubai Health Authority (DHA) and adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is anonymized, encrypted, and processed in compliance with these laws.
Clinical & Logistical Metadata
| Test Name | PPP1R8 Gene Cardiac Defects NGS Test (Sequencing) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3 mL EDTA tube) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available (8 AM – 11 PM) |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) with >100x mean read depth; SNV, Indel, and CNV detection |
| ICD-10-CM Code | I42.9 (Cardiomyopathy, unspecified), Q24.9 (Congenital malformation of heart, unspecified) |
| LOINC Code | 55233-1 (Genetic analysis for inherited heart disease) |
| DHA Facility License & Laboratory Address | License No: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians