Test Price
2,800 AED✅ Home Collection Available
COX15 Gene Sequencing for Fatal Infantile Cardioencephalomyopathy (Cytochrome c Oxidase Deficiency Type 2) in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين COX15 للكشف عن اعتلال القلب والدماغ القاتل عند الرضع في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Certified NGS and Confirmatory Sanger Sequencing.
✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain (8 AM – 11 PM) and VIP Mobile Phlebotomy.
✓ Clinical Guidance: Post‑test Telephonic Clinical Guidance included for result interpretation and genetic counselling.
✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
نقدم خدمة تحليل جيني متقدم لطفرة جين COX15 مع استشارة وراثية وتوصيل منزلي معتمد.
Overview
COX15 Gene Testing identifies pathogenic variants in the COX15 gene responsible for fatal infantile cardioencephalomyopathy, a severe mitochondrial disorder caused by cytochrome c oxidase deficiency type 2. This NGS‑based assay provides definitive molecular diagnosis, enabling precise genetic counselling, early intervention, and informed family planning.
يساعد تحليل جين COX15 في تحديد الطفرات المسببة لاعتلال القلب والدماغ القاتل عند الرضع الناجم عن نقص إنزيم السيتوكروم سي أوكسيداز من النوع الثاني.
| Feature | Our Test (Precision Medicine) | Closest Alternative (Standard Sanger) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (Illumina) with CNV detection + orthogonal confirmation | Single‑variant Sanger sequencing (locus‑specific) |
| Diagnostic Sensitivity | >99.9% for coding region & splice sites | ~90% if variant known; misses novel/rare variants |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks (when requiring multiple custom probes) |
| Sample Types | Whole Blood, Extracted DNA, FTA Card Blood Spot | Blood or Extracted DNA only |
| Regulatory | DHA Licensed | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Variable |
Physician Insight & Safety Protocol
“Early genetic confirmation of COX15‑related cardioencephalomyopathy is a pivotal step in guiding supportive cardiac and neurologic management while empowering families with accurate recurrence risk information. I urge you to correlate these results meticulously with mitochondrial enzyme assays and imaging, and to always involve a clinical geneticist. Please do not alter any current therapies without direct medical supervision.”
— Dr. PRABHAKAR REDDY, DHA License No. 61713011 (Clinical Geneticist)
MEDICATION WARNING: Do not discontinue any prescribed medication or supplement without explicit instruction from your treating consultant.
Exclusion Criteria & Emergency Red Flags
- Exclusion: This targeted test is not recommended for asymptomatic adults without a confirmed family mutation or strong clinical suspicion of COX15 deficiency. Pre‑test genetic counselling is mandatory.
- Red Flags: If the patient (especially an infant) develops acute respiratory failure, refractory seizures, or signs of heart failure, seek immediate emergency medical attention. The test result does not replace urgent clinical assessment.
- According to UAE Federal Decree‑Law No. 41 of 2024 (Art. 87) and the CDS Law 2026, genetic testing of minors requires documented informed consent from a legal guardian. All data is protected under UAE PDPL.
Patient FAQ & Clinical Guidance
1. What is the COX15 gene and the condition it causes?
The COX15 gene instructs the assembly of cytochrome c oxidase; harmful variants cause fatal infantile cardioencephalomyopathy type 2, a mitochondrial disorder with severe heart and brain involvement.
س: ما هو جين COX15 والحالة المرضية التي يسببها؟
ج: يوفر جين COX15 تعليمات لتجميع إنزيم السيتوكروم سي أوكسيداز، وتؤدي الطفرات فيه إلى اعتلال القلب والدماغ القاتل عند الرضع.
2. How is the test performed and what sample is needed?
A certified phlebotomist collects a small blood sample, extracted DNA, or a single drop on an FTA card from the comfort of your home, which is then analysed with high‑throughput Next‑Generation Sequencing.
س: كيف يتم إجراء الاختبار وما العينة المطلوبة؟
ج: تُسحب عينة دم بسيطة أو بقعة دم على بطاقة FTA منزلياً على يد ممرض معتمد، ثم تُحلل بتقنية التسلسل الجيني المتقدم.
3. How accurate is this test and can it be used for family screening?
Our NGS assay achieves 99.9% diagnostic sensitivity for all known pathogenic COX15 variants, making it reliable for confirming an affected child and subsequently testing at‑risk relatives for carrier status.
س: ما مدى دقة هذا الاختبار وهل يمكن استخدامه لفحص أفراد العائلة؟
ج: تصل حساسية الاختبار التشخيصية إلى 99.9% لجميع الطفرات المعروفة، مما يجعله موثوقاً لتأكيد الحالة ثم فحص حاملي المورثة في العائلة.
Licensed Facility: 9834453 | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Support: +971 545488731 (WhatsApp)
Methodology: Next‑Generation Sequencing (Illumina) with confirmatory Sanger sequencing. TAT: 3–4 weeks. Price: 2800 AED.
Relevant Specialists: Pediatric Neurologist, Pediatric Cardiologist, Clinical Geneticist (collaborative interpretation required).
ICD‑10‑CM 2026: E88.49 (Other mitochondrial disorders), I42.8 (Cardiomyopathy in mitochondrial disease), G93.40 (Encephalopathy, unspecified) | LOINC: 94196-5
Pre‑ Information: Clinical history review, genetic counselling session with pedigree charting, and informed consent (mandatory for minors per UAE CDS Law 2026).
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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