Test Price
2,800 AED✅ Home Collection Available
TNNI3 Gene Cardiomyopathy, Dilated Type 2A Genetic Test – UAE
Executive Summary & Core Metrics
This advanced genetic test offers complete sequencing of the TNNI3 gene with 99.9% diagnostic sensitivity, guiding personalized management and familial cascade screening for dilated cardiomyopathy type 2A.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test consultation included for result interpretation and next steps.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TNNI3 gene encodes cardiac troponin I, a protein critical for myocardial contraction; pathogenic variants cause autosomal dominant dilated cardiomyopathy type 2A. This Next-Generation Sequencing (NGS) test analyzes the entire coding region to identify disease-causing mutations, guiding personalized management and family screening.
The assay covers all exons and flanking intronic boundaries (±20 bp) for comprehensive variant detection, including single nucleotide variants (SNVs), insertions/deletions (indels), and copy number variants (CNVs) with high analytical resolution.
| Feature | Our Test (NGS) | Alternative (Targeted Genotyping) |
|---|---|---|
| Methodology | Next-Generation Sequencing | Sanger Sequencing / PCR |
| Scope | Full gene ±20 bp intronic boundaries | Known familial variant only |
| Variant Detection | SNVs, indels, CNVs (high resolution) | Single nucleotide change |
| Turnaround Time | 3–4 Weeks | 2–3 Weeks |
| Clinical Utility | Diagnosis & Prognosis in Probands | Cascade testing when mutation known |
Physician Insight & Safety Protocols
“A positive TNNI3 result signals a genetic predisposition, not a disease diagnosis; it must be interpreted alongside echocardiographic findings and a detailed three-generation family history. As a clinical genetics specialist, I guide patients through evidence-based risk stratification and tailored family screening.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA ID: 9294403
⚠ Medication Advisory
Do not discontinue any prescribed heart medication (beta-blockers, ACE inhibitors, diuretics, etc.) prior to or after testing without explicit consent from your treating physician. This genetic test does not replace clinical monitoring or medication management.
Exclusion Criteria & Emergency Red Flags
- Not intended for acute myocardial infarction triage or troponin blood level quantification.
- Avoid testing if a competing diagnosis fully explains cardiomyopathy (e.g., ischemic cardiomyopathy with fixed stenosis).
- Seek immediate emergency care if you experience sudden chest pain, fainting (syncope), severe shortness of breath, or palpitations with dizziness.
Patient FAQ & Clinical Guidance
1. What is the TNNI3 gene and how does it relate to dilated cardiomyopathy?
The TNNI3 gene encodes cardiac troponin I, a protein essential for heart muscle contraction. Pathogenic mutations disrupt contractile function, leading to dilated cardiomyopathy type 2A, an autosomal dominant condition characterized by progressive left ventricular enlargement and systolic dysfunction.
2. Do I need to fast or stop medications before this genetic test?
No fasting or medication adjustments are required for this DNA-based test. However, never discontinue prescribed cardiac medications without consulting your physician. Continue all treatments as directed before and after sample collection.
3. How accurate is the TNNI3 NGS test and what do results mean?
The test achieves over 99.9% analytical accuracy for detecting pathogenic TNNI3 variants. A positive result indicates a genetic predisposition that requires correlation with echocardiography and family history. Results help guide surveillance for at-risk relatives and inform lifestyle and therapeutic decisions.
4. Who should consider this test?
This test is appropriate for individuals with a clinical diagnosis of idiopathic dilated cardiomyopathy, a family history of dilated cardiomyopathy or sudden cardiac death, or unexplained left ventricular dysfunction. Pre-test genetic counseling is recommended to discuss implications and limitations.
UAE Regulatory & Data Privacy Adherence
This genetic test is performed under the regulatory oversight of the Dubai Health Authority (DHA) and complies with all applicable UAE federal laws:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – Ensures genomic data encryption, anonymization, and secure processing.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – Governs electronic health records and telemedicine consultation.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – Establishes patient consent and clinical safety standards for genetic testing.
Laboratory processes are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and adhere to DHA/MOHAP standards for molecular diagnostics.
Clinical & Logistical Metadata
| Test Name | TNNI3 Gene Sequencing – Dilated Cardiomyopathy Type 2A |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene analysis including exons and ±20 bp intronic boundaries |
| ICD-10-CM Code | I42.0 (Dilated cardiomyopathy) |
| LOINC Code | 94037-7 (TNNI3 gene full sequencing) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians