Test Price
2,800 AEDโ Home Collection Available
TCAP Gene Cardiomyopathy, Dilated Type 1N Genetic Test in UAE | AED 2,800 | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited next-generation sequencing (NGS) processing for the titin-cap gene.
- Premium Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across Dubai and major UAE cities.
- Clinical Guidance: Mandatory pre-test genetic counselling session with pedigree charting and telephonic post-test result interpretation by a Consultant Medical Geneticist.
- Insurance: Direct billing verification available via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The TCAP gene NGS test comprehensively sequences the titin-cap gene to identify pathogenic variants linked to dilated cardiomyopathy type 1N (CMD1N). This analysis enables definitive molecular diagnosis, accurate familial cascade screening, and personalised clinical management for patients presenting with left ventricular enlargement and systolic dysfunction of unknown aetiology.
Unlike targeted cardiac gene panels that may exclude deep intronic or regulatory regions, our full-gene sequencing approach with deletion and duplication analysis achieves deep coverage of approximately 200x across all coding and non-coding critical regions, ensuring detection of single nucleotide variants, small insertions and deletions, and larger structural rearrangements.
| Feature | Our TCAP Full NGS Test | Closest Alternative (Cardiac Gene Panel) |
|---|---|---|
| Accuracy / Precision | >99.9% sensitivity for all TCAP mutation classes; deep coverage ~200x | May miss rare intronic and non-coding variants; limited to pre-selected gene targets |
| Methodology | NGS with full gene sequencing and deletion/duplication analysis | Targeted NGS panel, often excludes deep intronic regions |
| Turnaround Time | 3โ4 weeks | 4โ6 weeks on average |
| Sample Requirement | Peripheral whole blood (2 mL EDTA) or saliva (Oragene kit) | Peripheral whole blood (2โ3 mL EDTA) |
| Reporting Depth | Complete gene-level report with ACMG classification and clinical annotations | Limited to panel gene list, often without structural variant analysis |
Physician Insight & Safety Protocols
This test is ordered and supervised by our Consultant Medical Geneticist to ensure accurate genotype-phenotype correlation and appropriate clinical actionability.
โA positive TCAP result carries profound implications for the patient and their family. My responsibility is to integrate the molecular findings with echocardiographic data, three-generation pedigree analysis, and longitudinal clinical assessment so that every recommendation translates into a practical, compassionate care pathway that respects both genomic science and the patientโs lived experience.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Medication Advisory
Do not discontinue, adjust, or alter any prescribed cardiac medication โ including beta-blockers, ACE inhibitors, or diuretics โ without direct consultation with your treating cardiologist. Abrupt changes in medication regimen can precipitate acute haemodynamic decompensation or arrhythmic events in patients with underlying dilated cardiomyopathy.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Active febrile illness (temperature >38ยฐC), haemodynamic instability (systolic BP <90 mmHg), or inability to provide informed consent autonomously.
- Exclusion: Minors without written informed consent from a legally authorised guardian, as mandated by UAE Federal Law No. 2 of 2019 and the Wadeema Child Rights Law.
- Red Flag: New-onset or worsening chest pain, severe dyspnoea at rest, exertional syncope, or palpitations with haemodynamic compromise โ seek emergency medical evaluation immediately.
- Red Flag: Any clinical suspicion of acute heart failure (e.g., orthopnoea, paroxysmal nocturnal dyspnoea, elevated jugular venous pressure) or sustained ventricular arrhythmia.
Patient FAQ & Clinical Guidance
1. What is the TCAP genetic test for dilated cardiomyopathy?
The TCAP NGS test identifies disease-causing mutations in the titin-cap gene, providing a definitive molecular diagnosis for dilated cardiomyopathy type 1N. This analysis enables cascade screening of at-risk family members and informs personalised surveillance and therapeutic strategies.
2. Why is pre-test genetic counselling mandatory before this test?
Pre-test counselling involves constructing a three-generation pedigree chart, evaluating the emotional and medical implications of possible results, and ensuring that fully informed consent is obtained as required by DHA regulations and UAE Federal Law No. 2 of 2019 on health information technology. This session also clarifies the potential for incidental findings and the implications for family members.
3. How are my genetic data and privacy protected under UAE law?
All genetic information is safeguarded under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. These frameworks mandate encrypted storage, role-based restricted access, and de-identified reporting for any secondary use of genomic data.
4. Can I have the sample collected at home, and what are the logistics?
Yes. For peripheral whole blood or saliva specimens, our VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection service is available daily from 8 AM to 11 PM across Dubai, Abu Dhabi, and the Northern Emirates. A licensed nurse will collect the sample at your residence, workplace, or hotel, and the specimen is transported under continuous temperature monitoring to our ISO-accredited laboratory.
5. What does the test result report include, and how is it delivered?
The report includes full gene coverage metrics, all detected variants classified according to ACMG/AMP 2015 guidelines, a clinical interpretation section with phenotype correlation, and recommendations for family cascade testing. Results are delivered electronically via a secure patient portal within 3โ4 weeks, followed by a telephonic consultation with our Consultant Medical Geneticist.
UAE Regulatory & Data Privacy Adherence
Regulatory & Privacy Compliance: This test is performed under ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139). All clinical and genomic data handling adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and Federal Decree-Law No. 4 of 2016 on Medical Liability. Patient consent procedures follow the Wadeema Child Rights Law for minor participants. Our DHA-licensed facility ensures encrypted data storage with role-based access controls and de-identified reporting for research or quality assurance purposes.
Clinical & Logistical Metadata
| Test Name | TCAP Gene Cardiomyopathy, Dilated Type 1N (CMD1N) Genetic Test |
| Price (AED) | AED 2,800 |
| Turnaround Time | 3โ4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (2 mL EDTA) or saliva (Oragene kit) โ VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with full gene sequencing, deletion/duplication analysis (MLPA), and variant classification per ACMG/AMP 2015 guidelines |
| ICD-10-CM Code | I42.0 |
| LOINC Code | 51958-7 |
| DHA Facility License & Address | DHA Facility License Number: 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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