Test Price
2,800 AED✅ Home Collection Available
SCN5A Gene Dilated Cardiomyopathy Type 1E Genetic Test in UAE | 2800 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
The SCN5A gene test utilizes Next-Generation Sequencing (NGS) to detect pathogenic variants associated with Dilated Cardiomyopathy Type 1E, enabling precise diagnosis, personalized treatment, and informed family screening. This assay interrogates the full coding region and splice junctions of SCN5A with analytical sensitivity exceeding 99.9%. All results are interpreted according to ACMG/AMP guidelines and confirmed by orthogonal methodology when clinically indicated. The test is priced at 2,800 AED with a turnaround time of 3 to 4 weeks from sample receipt.
Test Overview & Methodology
Dilated cardiomyopathy type 1E (CMD1E) is an autosomal dominant condition caused by heterozygous pathogenic variants in the SCN5A gene. This gene encodes the cardiac sodium channel alpha subunit, which is critical for normal cardiac conduction and contractile function. Our NGS-based analysis provides comprehensive coverage of all coding exons and flanking intronic regions, detecting single nucleotide variants, small insertions and deletions, and copy number variations with high confidence.
| Feature | Our Test (NGS – UAE) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision & Coverage | Full gene sequencing, 99.9% analytical sensitivity; detects all variant types | Targeted exonic regions only; may miss deep intronic or large deletions |
| Methodology | NGS (Next-Generation Sequencing) – LC‑MS/MS validated library preparation, clinical-grade bioinformatics | Capillary electrophoresis based; lower throughput, manual interpretation |
| Turnaround Time | 3 to 4 weeks | 6 to 8 weeks |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
"A positive SCN5A result must be correlated with echocardiographic findings, electrocardiographic data, and a three-generation pedigree to guide implantable cardioverter-defibrillator consideration or pharmacologic intervention. Genetic risk stratification enhances clinical decision-making but does not substitute for comprehensive cardiovascular assessment. Pre-test genetic counselling is mandatory to ensure informed consent and appropriate variant interpretation."
Advisory: Medication Continuation
Do not discontinue prescribed cardiac medications, including beta-blockers, ACE inhibitors, or anticoagulants, without explicit instruction from your treating physician. Sudden withdrawal may precipitate clinical decompensation.
Exclusion Criteria & Emergency Red Flags
- Absolute exclusion: Testing of minors without informed consent from a legal guardian; active hemodynamic instability.
- Relative exclusion: Pregnancy – consult your obstetrician before proceeding; acute febrile illness may postpone collection.
- Pre-test requirement: A mandatory genetic counselling session to document family pedigree and discuss implications of potential results.
- ER Red Flags: New-onset chest pain, syncope, sustained palpitations, or documented arrhythmia – seek immediate emergency evaluation.
Patient FAQ & Clinical Guidance
1. Who should consider the SCN5A dilated cardiomyopathy genetic test?
Summary: Any individual with unexplained dilated cardiomyopathy, a family history of sudden cardiac death, or suspicious ECG anomalies should pursue SCN5A genetic testing.
This test is indicated for patients with clinical or imaging evidence of dilated cardiomyopathy, those with a first-degree relative carrying a known SCN5A pathogenic variant, and asymptomatic individuals with a high-risk family background. Early identification enables preventive strategies including implantable cardioverter-defibrillator placement and lifestyle optimization.
2. How accurate is the NGS method for detecting SCN5A variants?
Summary: Our NGS platform achieves greater than 99.9% analytical sensitivity for single nucleotide variants and indels across the entire SCN5A gene, surpassing Sanger sequencing coverage.
Using LC‑MS/MS-validated library preparation and clinically curated bioinformatics, the assay also detects copy number variations often missed by traditional methods. All clinically actionable variants are confirmed by orthogonal techniques when indicated, ensuring diagnostic-grade accuracy.
3. What does the 2800 AED price include, and how do I arrange home collection?
Summary: The 2800 AED fee covers genetic counselling, hospital-grade phlebotomy at your location, cold-chain logistics, full NGS analysis, and a telephonic post-test consultation with a DHA-licensed Consultant Medical Geneticist.
To book, message our WhatsApp support at +971 54 548 8731. Our team verifies insurance eligibility, schedules a mobile phlebotomist visit between 8 AM and 11 PM, and delivers the final report within 3–4 weeks through a secure patient portal. Home collection is available daily across Dubai and all seven emirates.
UAE Regulatory & Data Privacy Adherence
This genetic testing service operates in full compliance with UAE federal frameworks. All personal genomic data is processed and stored under the provisions of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE holds DHA Facility License number 1143 and maintains ISO 9001:2015 certification for its quality management system.
Clinical & Logistical Metadata
| Test Name | SCN5A Gene Dilated Cardiomyopathy Type 1E Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood (collected in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) with LC‑MS/MS validated library preparation |
| ICD-10-CM Code | I42.0 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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