Test Price
2,800 AED✅ Home Collection Available
DSG2 Gene (Arrhythmogenic Right Ventricular Cardiomyopathy Type 10) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing with high-depth NGS coverage.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across Dubai and the Northern Emirates.
- Clinical Guidance: Telephonic post-test genetic counselling included for result interpretation and family cascade screening pathways.
- Insurance & Billing: Direct billing verification via WhatsApp +971 54 548 8731; self-pay and insurance options accepted.
Test Overview & Methodology
This molecular genetic test employs next-generation sequencing (NGS) to analyze the full coding region and splice-site junctions of the DSG2 gene. Pathogenic variants in DSG2 are causative for Arrhythmogenic Right Ventricular Cardiomyopathy Type 10 (ARVC10), a heritable myocardial disorder characterized by fibrofatty replacement of the right ventricular myocardium, ventricular arrhythmias, and elevated risk of sudden cardiac death in young adults and athletes. High-depth coverage ensures detection of single-nucleotide variants, small insertions and deletions, and copy-number alterations with 99.9% analytical sensitivity.
| Feature | Our Test (NGS DSG2 Full Gene) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision / Coverage | >99.9% analytical sensitivity; full gene and all canonical splice sites | ~95% sensitivity; limited to pre-selected exons only |
| Methodology | Next-generation sequencing with high-depth coverage and ISO 9001:2015 processing | Capillary electrophoresis-based single-region analysis |
| Turnaround Time | 3–4 weeks (expedited reporting available on request) | 6–10 weeks |
| Clinical Utility | Family cascade screening, sports eligibility assessment, ICD implantation planning | Confirmation of known familial variant only |
Physician Insight & Safety Protocols
“As a Consultant in Medical Genetics, I recognize that a molecular diagnosis in the DSG2 gene provides a critical anchor for family cascade screening and risk stratification. Nonetheless, a genetic finding must never be interpreted in isolation; variants of uncertain significance require careful segregation analysis and multidisciplinary evaluation before any clinical decisions are made. Patients should continue all prescribed therapies and discuss any management changes with their treating cardiologist.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory – Do Not Discontinue Prescribed Therapy
Genetic test results do not replace ongoing medical management. Do not stop, reduce, or alter any prescribed cardiac medications—including beta-blockers, antiarrhythmic agents, or anticoagulants—without direct consultation with your treating cardiologist. Abrupt discontinuation may precipitate life-threatening arrhythmic events.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals experiencing active life-threatening arrhythmia, hemodynamic instability, or acute cardiac decompensation should seek immediate emergency care. Sample collection for this genetic test will be deferred until clinical stabilization is confirmed by the attending physician.
- Emergency Red Flags: Sudden chest pain, unexplained syncope, sustained palpitations, or a first-degree relative who suffered sudden cardiac death warrant immediate emergency evaluation—do not wait for a scheduled home phlebotomy appointment.
Patient FAQ & Clinical Guidance
1. What is the DSG2 gene test and why is it important?
Snippet: This test sequences the entire DSG2 gene to detect pathogenic mutations responsible for Arrhythmogenic Right Ventricular Cardiomyopathy Type 10, a leading cause of sudden cardiac death in young adults and athletes. Early molecular diagnosis enables proactive surveillance, family screening, and lifestyle modifications.
2. Who should consider this genetic test?
Snippet: Individuals with a confirmed clinical diagnosis of ARVC, unexplained right ventricular structural abnormalities, a family history of ARVC, or a first- or second-degree relative who experienced sudden cardiac death before age 50 should undergo testing for definitive risk stratification.
3. What does a positive result mean and what are the next steps?
Snippet: A positive result confirms a pathogenic variant in DSG2, enabling cascade screening of at-risk relatives, personalized surveillance intervals, and evaluation for an implantable cardioverter-defibrillator (ICD) to prevent sudden death. All positive results are reviewed in a multidisciplinary setting before clinical action is taken.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed under strict confidentiality protocols. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE holds DHA Facility License No. 1143 and operates under ISO 9001:2015 quality management standards.
Clinical & Logistical Metadata
| Test Name | DSG2 Gene (Arrhythmogenic Right Ventricular Cardiomyopathy Type 10) Genetic Test – Next-Generation Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (expedited reporting available on request) |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) – VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with high-depth coverage, full gene and splice-site analysis, ISO 9001:2015 accredited |
| ICD-10-CM Code | I42.8 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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