Test Price
2,800 AEDโ Home Collection Available
๐ Results in 3โ4 weeks
TRPM4 Gene Progressive Familial Heart Block Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
Molecular Diagnosis for Inherited Cardiac Arrhythmia Risk
Next-generation sequencing (NGS) analysis of the TRPM4 gene to detect pathogenic variants causing progressive familial heart block type IA (PFHB1). Our service ensures 99.9% diagnostic sensitivity through ISO 9001:2015 accredited processing, complemented by VIP mobile phlebotomy for home blood collection (available 8 AM โ 11 PM) and telephonic post-test genetic consultation.
- Accuracy Guarantee: 99.9% analytical sensitivity with full exon and deep intronic coverage.
- Premium Logistics: Temperature-controlled courier and at-home blood draw by certified phlebotomists.
- Clinical Guidance: One-on-one telephonic result interpretation with a Board-Certified Clinical Geneticist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing test analyzes the entire coding region and intron-exon boundaries of the TRPM4 gene to identify pathogenic variants associated with progressive familial heart block type IA (PFHB1). The test detects single-nucleotide variants, insertions/deletions, and splice-site alterations with high sensitivity, enabling early diagnosis and cascade family screening.
| Feature | Our Test (TRPM4 NGS) | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Precision | >99.9% analytical sensitivity; full gene coverage including deep intronic variants | ~98% for targeted exons only |
| Method | NGS (Illumina NovaSeqโข) with confirmatory Sanger | Sanger sequencing of selected exons |
| Turnaround Time | 3โ4 weeks | 4โ6 weeks |
| Price (AED) | 2,800 | 2,200โ2,500 (limited scope) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA: 9294403): โA TRPM4 variant must always be interpreted within the full clinical picture โ a negative result does not exclude inherited arrhythmia syndromes, and a positive result requires cascade family screening and cardiology follow-up. I urge every patient to discuss findings with a cardiologist or clinical geneticist before making any medical decision.โ
Advisory Notice
Important Medication Warning
Do not discontinue prescribed cardiac medications (e.g., beta-blockers, antiarrhythmics) without consulting your doctor. Genetic results do not replace clinical management.
Exclusion Criteria & Emergency Red Flags
- Active febrile illness, severe anemia, or haemodynamic instability โ postpone blood draw.
- Known bleeding disorder or anticoagulation therapy not optimized for phlebotomy.
- If you experience syncope, chest pain, or new-onset palpitations, seek emergency care immediately โ do not wait for genetic results.
Patient FAQ & Clinical Guidance
1. How does the TRPM4 NGS test diagnose progressive familial heart block?
This test directly sequences the entire TRPM4 gene to identify pathogenic variants with >99.9% sensitivity, providing a molecular diagnosis that confirms the subtype and guides family screening.
2. Can the test be performed on minors in the UAE?
Genetic testing of minors is permitted under UAE law with informed parental consent and mandatory pre-test genetic counseling. A clinical geneticist will assess the clinical indication before proceeding.
3. What if my result is positive but I have no symptoms?
A positive result indicates a pathogenic variant that increases lifetime risk of heart block. You will be referred for cardiology evaluation, periodic ECGs, and cascade family testing even if currently asymptomatic.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance: DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed within UAE borders. The laboratory is licensed by the Dubai Health Authority (License No. 1143) and operates under rigorous ISO quality standards.
Clinical & Logistical Metadata
| Test Name | TRPM4 Gene Progressive Familial Heart Block Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Saliva (Oragene DNA Saliva Kit) |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | I44.2 |
| LOINC Code | 55233-1 |
| DHA Facility License & Laboratory Address Invariants | DHA License No. 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
["No specific fasting required.", "Inform the lab of any current medications."]
Medically Reviewed by Dr. Lina Osama Zaki Quteineh
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians