Molecular Diagnostics → Bone Marrow Failure

Test Price

3,000 AED

✅ Home Collection Available

Bone Marrow Failure Anemia Panel Genetic Test in UAE | 3000 AED | 2026 DHA Guidelines

تحليل لوحة فشل نخاع العظم وفقر الدم الوراثي بتقنية التسلسل الجيني المتقدم في الإمارات | 3000 درهم | معتمد من هيئة الصحة بدبي

A clinically validated, 145+ gene Next-Generation Sequencing (NGS) panel designed to identify pathogenic germline variants underlying inherited bone marrow failure syndromes, congenital anemias, and predisposition to myelodysplasia. Delivered under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited processing with DHA-licensed phlebotomy and full compliance with Federal Decree-Law No. 41 of 2024.

3000 AED All-Inclusive Package

⏱ TAT: 3–4 Weeks

🧬 145+ Genes Sequenced

🏠 Home Collection 8 AM–11 PM

📋 Insurance Direct Billing

Executive Summary — الملخص التنفيذي

✅ 99.9% Diagnostic Sensitivity: Variant detection at ≥20% allele fraction with 100x minimum mean depth of coverage across all target regions. ISO 9001:2015 accredited laboratory processing ensures clinical-grade analytical validity for every report issued.

🚚 Premium Cold-Chain Home Collection: DHA-licensed mobile phlebotomy teams dispatched across all seven emirates. ISO-certified cold-chain logistics maintain specimen integrity at 2–8°C with real-time GPS-tracked transport, available daily from 8:00 AM to 11:00 PM.

📞 Post-Test Clinical Guidance: Complimentary 20-minute telephonic consultation with a clinical genomicist to interpret results, clarify variant classifications, and outline clinical correlation steps. Available in English and Arabic.

💳 Direct Insurance Billing: WhatsApp your Emirates ID and insurance card to +971 54 548 8731 for real-time eligibility verification and pre-approval processing within 60 minutes.

✅ حساسية تشخيصية بنسبة 99.9%: كشف المتغيرات الجينية بدقة تشخيصية فائقة من خلال مختبر معتمد وفق معيار الآيزو 9001:2015، مع تغطية تسلسلية شاملة لجميع المناطق المستهدفة بمتوسط عمق لا يقل عن 100x.

🚚 خدمة السحب المنزلي المتميزة: فرق سحب دم متنقلة مرخصة من هيئة الصحة بدبي تغطي جميع إمارات الدولة السبع، مع نقل مبرد معتمد وفق معايير الآيزو لضمان سلامة العينة من الساعة 8 صباحاً حتى 11 مساءً يومياً.

📞 استشارة طبية ما بعد الفحص: جلسة استشارية هاتفية مجانية مدتها 20 دقيقة مع أخصائي الجينوميات السريرية لتفسير النتائج وتوضيح تصنيف المتغيرات الجينية وتوجيه الخطوات السريرية اللاحقة.

Clinical Test Overview

The Bone Marrow Failure Anemia Panel is a comprehensive constitutional genetic test employing Next-Generation Sequencing (NGS) technology to interrogate the full coding regions and splice-site junctions of over 145 genes clinically associated with inherited bone marrow failure syndromes (IBMFS). This panel covers Fanconi anemia (FANCA through FANCM), Diamond-Blackfan anemia (RPL5, RPL11, RPL15, RPS19, and related ribosomal protein genes), Shwachman-Diamond syndrome (SBDS), dyskeratosis congenita (DKC1, TERT, TINF2, RTEL1), congenital dyserythropoietic anemias, and severe congenital neutropenia-associated genes including ELANE, HAX1, and CSF3R.

تغطي هذه اللوحة الجينية الشاملة أكثر من 145 جيناً مرتبطاً بمتلازمات فشل نخاع العظم الوراثية، بما في ذلك فقر الدم فانكوني، وفقر الدم Diamond-Blackfan، ومتلازمة Shwachman-Diamond، وخلل التقرن الخلقي، وفقر الدم الخلقي غير المنتج للكريات الحمراء.

Why This Test Outperforms Alternatives

Parameter	Our NGS Panel	Single-Gene / Karyotype
Genes Analyzed	145+ Simultaneously	1–5 Genes per Test
Variant Resolution	Single-Nucleotide to CNV	Limited to Targeted Loci
Turnaround Time	3–4 Weeks	6–12 Weeks (Sequential)
ACMG Classification	Per 2026 Guidelines	Variable / Outdated
Clinical Utility	Diagnostic + Prognostic + Familial	Diagnostic Only

Physician Insight & Safety Protocol

A Note from Dr. Prabhakar Reddy — DHA License: 61713011

"As a Consultant Hematopathologist with over two decades of experience interpreting constitutional bone marrow failure panels, I want to emphasize that a genetic diagnosis is a powerful clinical tool — but it must always be correlated with your complete hematologic profile, family history, and physical examination findings. A pathogenic variant alone does not define your clinical trajectory; it informs a personalized surveillance and management plan that your hematologist will design in partnership with you."

"This panel detects germline variants with high analytical sensitivity; however, somatic mosaicism, deep intronic variants beyond canonical splice sites, and mitochondrial genome variants are not captured. If clinical suspicion remains high despite a negative result, further investigative modalities — including whole genome sequencing or bone marrow biopsy with cytogenetic analysis — may be warranted. Please review every result with your treating physician."

⚠️ Medication Safety Notice

Do not discontinue, modify, or initiate any prescribed medication — including corticosteroids, androgens (e.g., danazol, oxymetholone), thrombopoietin receptor agonists (e.g., eltrombopag, romiplostim), immunosuppressants, or iron chelators — based solely on genetic test results. All therapeutic decisions must be made in consultation with your treating hematologist.

🚨 Patient Safety: Exclusion Criteria & Emergency Red Flags

Exclusion Criteria — When This Test Is NOT Appropriate:

Acute medical emergencies requiring immediate transfusion or hospitalization — stabilize patient first.
Suspected acute leukemia with >20% circulating blasts — prioritize bone marrow biopsy and flow cytometry.
Patients who have received allogeneic stem cell transplantation with documented full donor chimerism — donor DNA will confound results.
Minors below 18 years without parental/legal guardian consent, per UAE CDS Law 2026 genetic testing provisions.
Inadequate sample volume (<2 mL whole blood in EDTA) or hemolyzed/clotted specimens.

🚑 Emergency Red Flags — Seek Immediate Medical Attention:

Spontaneous, non-traumatic bleeding from mucosa, gums, or epistaxis unresponsive to pressure.
Fever ≥38.3°C with absolute neutrophil count below 0.5 × 10⁹/L — risk of life-threatening sepsis.
New-onset petechiae, purpura, or ecchymoses in a non-ambulatory patient.
Sudden visual changes or retinal hemorrhages in a thrombocytopenic patient.
Syncope, severe pallor, or dyspnea at rest indicating critical anemia (Hb <5 g/dL).

Patient Frequently Asked Questions — الأسئلة الشائعة للمرضى

Q1: What does the Bone Marrow Failure Anemia NGS Panel actually test for, and who should consider it?

This NGS panel analyzes 145+ genes associated with inherited bone marrow failure syndromes, identifying pathogenic germline variants that cause or predispose individuals to aplastic anemia, myelodysplastic syndrome, and congenital cytopenias. The test is clinically indicated for patients presenting with unexplained cytopenias (anemia, neutropenia, thrombocytopenia) before age 40, individuals with a family history of bone marrow failure or MDS/AML, those with congenital anomalies suggestive of Fanconi anemia or Diamond-Blackfan anemia, and pre-transplant donor screening when familial hematopoietic disorders are suspected. In the UAE, where consanguinity rates elevate recessive disease risk, this panel is particularly valuable for couples undergoing premarital genetic screening and families with hematologic disease clustering.

Q2: How is the sample collected, what is the turnaround time, and how do I prepare?

Sample collection requires a standard venipuncture yielding 3–5 mL of whole blood in an EDTA tube, with results delivered within 3 to 4 weeks following ISO-certified NGS library preparation and clinically validated bioinformatic analysis. Our DHA-licensed phlebotomists perform hospital-grade home collection across all seven emirates daily from 8:00 AM to 11:00 PM. No fasting is required. However, patients who have received a blood transfusion within the past 14 days should inform the laboratory, as donor leukocyte DNA may transiently interfere with germline variant calling. A pre-test genetic counseling session — mandatory per UAE Federal Decree-Law No. 41 of 2024, Article 87 — will document your three-generation pedigree and ensure informed consent. For dried blood spot (FTA card) collection, only two drops of capillary blood are required, making this option suitable for pediatric patients or remote-area collection.

Q3: Will my UAE health insurance cover this genetic test, and what documents do I need?

Most UAE comprehensive health insurance plans — including Daman Enhanced, Thiqa, Enaya, and major international policies — provide coverage for medically indicated Genetic Testing when accompanied by a hematologist's referral letter and supporting clinical documentation. Direct billing verification is available via WhatsApp: simply send your Emirates ID, insurance card front and back, and the referring physician's test request form to +971 54 548 8731 for confirmation within 60 minutes. Self-pay patients receive a detailed itemized invoice with ICD-10-CM coding (D61.9, D46.9, or Z15.89 as clinically appropriate) suitable for reimbursement claims. All genetic data is handled in strict compliance with UAE Personal Data Protection Law (PDPL), classified as sensitive personal data, and is never shared with third parties without explicit written consent.

ملخص الأسئلة الشائعة باللغة العربية

ما هي الفحوصات التي تغطيها لوحة فشل نخاع العظم؟ تغطي هذه اللوحة الجينية تحليل 145+ جيناً مرتبطاً بمتلازمات فشل نخاع العظم الوراثية، لتحديد الطفرات الجينية المسببة لفقر الدم اللاتنسجي ومتلازمة خلل التنسج النقوي.

كيف يتم جمع العينة؟ يتم سحب عينة دم وريدي بسيطة (3-5 مل) عبر فريق تمريض مرخص من هيئة الصحة بدبي في منزلك، مع توفر خدمة التوصيل المبرد المعتمد وفق معايير الآيزو، وتصدر النتائج خلال 3 إلى 4 أسابيع.

هل يغطي التأمين الصحي تكلفة الفحص؟ تغطي معظم خطط التأمين الصحي الشامل في الإمارات — بما في ذلك ضمان المحسّن، وثيقة، وعناية — تكلفة الفحص الجيني عند تقديم خطاب إحالة من استشاري أمراض الدم. للتحقق من التغطية، أرسل بطاقة الهوية الإماراتية وبطاقة التأمين عبر واتساب على الرقم +971 54 548 8731.

🏛 UAE Regulatory Compliance

Federal Decree-Law No. 41 of 2024 (Human Genetic Testing Regulation, Art. 87)
UAE CDS Law 2026 — Minor Genetic Screening Provisions
UAE PDPL — Genetic Data Classified as Sensitive Personal Data
DHA Facility License: 9834453

🔬 Quality & Accreditation

ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139)
ACMG/AMP 2026 Variant Classification Guidelines
Illumina NovaSeq X Plus Platform
College of American Pathologists (CAP) Proficiency Testing Participant

📋 Clinical Governance

Reviewed by Dr. Prabhakar Reddy, DHA: 61713011
Consultant Hematopathologist — 22 Years Experience
Pre- and Post- Genetic Counseling Mandatory
Result Escalation to Hematologist Within 24 Hours for Pathogenic Findings

Book Your Home Collection Today

Available 8 AM – 11 PM | All Emirates | ISO-Certified Cold Chain

WhatsApp: +971 54 548 8731 Call Now

This page is published for clinical education and patient information purposes. All genetic testing is performed in compliance with UAE Federal Decree-Law No. 41 of 2024 and applicable DHA/MOHAP regulations. © 2026 — All Rights Reserved.

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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.

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