Test Price
3,000 AED✅ Home Collection Available
Bone Marrow Failure Anemia Panel Genetic Test in UAE | 3,000 AED
Executive Summary & Core Metrics
Core Metrics at a Glance
Test Overview & Methodology
The Bone Marrow Failure Anemia Panel is a comprehensive constitutional genetic test employing Next-Generation Sequencing (NGS) technology to interrogate the full coding regions and splice-site junctions of over 145 genes clinically associated with inherited bone marrow failure syndromes (IBMFS). This panel covers Fanconi anemia (FANCA through FANCM), Diamond-Blackfan anemia (RPL5, RPL11, RPL15, RPS19, and related ribosomal protein genes), Shwachman-Diamond syndrome (SBDS), dyskeratosis congenita (DKC1, TERT, TINF2, RTEL1), congenital dyserythropoietic anemias, and severe congenital neutropenia-associated genes including ELANE, HAX1, and CSF3R.
This comprehensive panel is clinically indicated for patients presenting with unexplained cytopenias before age 40, individuals with a family history of bone marrow failure or myelodysplastic syndrome, and pre-transplant donor screening when familial hematopoietic disorders are suspected.
Why This Test Outperforms Alternatives
| Parameter | Our NGS Panel | Single-Gene / Karyotype |
|---|---|---|
| Genes Analyzed | 145+ Simultaneously | 1–5 Genes per Test |
| Variant Resolution | Single-Nucleotide to CNV | Limited to Targeted Loci |
| Turnaround Time | 3–4 Weeks | 6–12 Weeks (Sequential) |
| Variant Classification | ACMG/AMP Guidelines | Variable / Outdated |
| Clinical Utility | Diagnostic + Prognostic + Familial | Diagnostic Only |
Physician Insight & Safety Protocols
A Note from Ms. Lina Osama Zaki Quteineh — Consultant Medical Genetics, DHA License: 9294403
"In my practice as a clinical geneticist, comprehensive panel-based NGS testing represents the definitive first-tier diagnostic approach for suspected inherited bone marrow failure syndromes. A molecular diagnosis enables precisely targeted surveillance, hematopoietic stem cell transplantation planning, and accurate recurrence risk counseling for families."
"Nevertheless, every result—whether positive, negative, or a variant of uncertain significance—must be interpreted within the context of the patient's full hematologic parameters, bone marrow histology, and family pedigree. This integrated approach is the gold standard for precision medicine in the UAE. Please ensure that a pre-test genetic counseling session has been completed to document a three-generation pedigree and secure informed consent."
Patient Safety: Pre-Test Considerations & Emergency Red Flags
Contraindications & Exclusion Criteria:
- Acute medical emergencies requiring immediate transfusion or hospitalization—stabilize patient first.
- Suspected acute leukemia with >20% circulating blasts—prioritize bone marrow biopsy and flow cytometry.
- Patients who have received allogeneic stem cell transplantation with documented full donor chimerism.
- Minors below 18 years without explicit parental or legal guardian consent.
- Inadequate sample volume (<2 mL whole blood in EDTA) or hemolyzed/clotted specimens.
Emergency Red Flags—Seek Immediate Care:
- Spontaneous, non-traumatic bleeding from mucosa, gums, or epistaxis unresponsive to pressure.
- Fever ≥38.3°C with absolute neutrophil count below 0.5 × 10⁹/L.
- New-onset petechiae, purpura, or ecchymoses in a non-ambulatory patient.
- Sudden visual changes or retinal hemorrhages in a thrombocytopenic patient.
- Syncope, severe pallor, or dyspnea at rest indicating critical anemia (Hb <5 g/dL).
Patient FAQ & Clinical Guidance
1. What does the Bone Marrow Failure Anemia NGS Panel test for, and who should consider it?
This NGS panel analyzes 145+ genes associated with inherited bone marrow failure syndromes, identifying pathogenic germline variants that cause or predispose individuals to aplastic anemia, myelodysplastic syndrome, and congenital cytopenias. The test is clinically indicated for patients presenting with unexplained cytopenias before age 40, individuals with a family history of bone marrow failure or MDS/AML, those with congenital anomalies suggestive of Fanconi anemia or Diamond-Blackfan anemia, and pre-transplant donor screening when familial hematopoietic disorders are suspected.
2. How is the sample collected, what is the turnaround time, and how do I prepare?
Sample collection requires a standard venipuncture yielding 3–5 mL of whole blood in an EDTA tube, with results delivered within 3 to 4 weeks following ISO-certified NGS library preparation and clinically validated bioinformatic analysis. Our DHA-licensed phlebotomists perform hospital-grade home collection across all seven emirates daily from 8:00 AM to 11:00 PM. No fasting is required. However, patients who have received a blood transfusion within the past 14 days should inform the laboratory, as donor leukocyte DNA may transiently interfere with germline variant calling. A pre-test genetic counseling session is mandatory per UAE regulation to document your three-generation pedigree and ensure informed consent.
3. Will my UAE health insurance cover this genetic test, and what documents do I need?
Most UAE comprehensive health insurance plans—including Daman Enhanced, Thiqa, Enaya, and major international policies—provide coverage for medically indicated Genetic Testing when accompanied by a hematologist's referral letter and supporting clinical documentation. Direct billing verification is available via WhatsApp: simply send your Emirates ID, insurance card front and back, and the referring physician's test request form to +971 54 548 8731 for confirmation within 60 minutes. Self-pay patients receive a detailed itemized invoice with ICD-10-CM coding suitable for reimbursement claims. All genetic data is handled in strict compliance with UAE Personal Data Protection Law (PDPL), classified as sensitive personal data, and is never shared with third parties without explicit written consent.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Protection
Your genetic data is classified as sensitive personal data under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). Strict access controls, encryption, and consent protocols are enforced to safeguard your privacy.
Health Information Governance
All health data and digital infrastructure comply with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields (ICT Health Law), ensuring the highest standards of data security and interoperability.
Clinical Safety & Patient Consent
All testing procedures and patient consent frameworks adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, guaranteeing patient safety, pre-test counseling, and ethical clinical practice.
Clinical & Logistical Metadata
| Test Name | Bone Marrow Failure Anemia Panel (NGS) |
| Price (AED) | 3,000 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA Tube) |
| Methodology Used | Next-Generation Sequencing (NGS), Illumina Platform |
| ICD-10-CM Code | D61.9, D46.9 |
| LOINC Code | 50398-6 |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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