Test Price
2,800 AED✅ Home Collection Available
AVPR2 Gene Nephrogenic Diabetes Insipidus, X‑linked Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary telephonic post‑test clinical correlation and result interpretation by a DHA‑licensed physician.
- Insurance: Instant direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The AVPR2 Gene NGS Test analyzes the entire coding region of the arginine vasopressin receptor 2 gene, providing a definitive molecular diagnosis for X‑linked nephrogenic diabetes insipidus with 99.9% analytical sensitivity. The test employs Next‑Generation Sequencing to detect single nucleotide variants, insertions, deletions, and copy number changes across the full gene including intronic boundaries. This technology surpasses traditional Sanger sequencing in coverage and sensitivity.
| Feature | Our Test (AVPR2 NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Technology | Next‑Generation Sequencing (full exons & intronic boundaries) | Sanger sequencing (selected exons, limited deep intronic coverage) |
| Analytical Sensitivity | 99.9% | ~95% |
| Turnaround Time | 3–4 Weeks | 2–3 Weeks |
| Price | 2,800 AED | 2,500 – 3,500 AED |
| Genetic Counseling Included | Yes (pedigree & risk assessment) | Often separate |
Physician Insight & Safety Protocols
“In my practice, a definitive molecular diagnosis of X-linked nephrogenic diabetes insipidus through AVPR2 sequencing transforms care for families—removing diagnostic uncertainty, guiding targeted therapy, and enabling informed family planning. Every variant requires careful correlation with clinical and biochemical findings to avoid misinterpretation. I always recommend pre- and post-test genetic counseling.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed medication (e.g., thiazides, amiloride) without consulting your doctor. Sudden withdrawal may cause dangerous electrolyte imbalances or severe dehydration. Always discuss any adjustments with your healthcare provider.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Recent blood transfusion (wait 2 weeks); active hemolysis; severe needle phobia without alternative DNA collection (buccal swab/FTA card).
- Emergency Red Flags (seek immediate care): Signs of hypernatremia (confusion, muscle twitching, severe thirst unrelieved by water), inability to keep fluids down, or weight loss >5% in 24 hours.
- Home Collection Safety: All phlebotomists are DHA‑registered and carry emergency kits; if you feel faint or unwell during collection, inform the staff immediately.
Patient FAQ & Clinical Guidance
1. What is the AVPR2 gene test, and how is it performed?
AVPR2 gene testing via NGS on a blood sample identifies mutations linked to X‑linked nephrogenic diabetes insipidus. A small blood sample (or DNA from a cheek swab/FTA card) is collected at home by our licensed phlebotomist. The DNA is then sequenced using Next‑Generation Sequencing to read the entire AVPR2 gene. The report is reviewed by a clinical geneticist and shared with your referring physician within 3–4 weeks.
2. How long do results take, and how will I receive them?
Results take 3 to 4 weeks as we perform thorough next‑generation sequencing and confirmation analysis. Once completed, a secure electronic report is sent to your ordering physician. You will also be offered a telephonic consultation with a DHA‑licensed clinician to explain the findings in plain language and answer any questions.
3. Is this test necessary if I have symptoms of diabetes insipidus?
Yes, it confirms X‑linked nephrogenic diabetes insipidus, differentiates from central DI, and guides treatment planning. Clinical symptoms such as polyuria, polydipsia, and hypernatremia alone cannot distinguish between nephrogenic and central forms. This genetic test provides a definitive answer, preventing unnecessary vasopressin trials and allowing tailored management, especially critical in infants and children where dehydration risk is high.
UAE Regulatory & Data Privacy Adherence
This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is stored on encrypted UAE‑based servers with explicit consent. The laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | AVPR2 Gene Complete Sequencing (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Blood (EDTA), FTA Card, or Extracted DNA |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD-10-CM Code | N25.1, Z13.79, Z84.89 |
| LOINC Code | 81267-8 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians