Test Price
130 AED✅ Home Collection Available
Anti-Smith (Sm) IgG Antibody Test in UAE | 130 AED | DHA Licensed Lab
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% clinical sensitivity via ISO 9001:2015 certified processing.
- Premium Home Collection: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Post-Test Guidance: Telephonic consultation with a qualified physician to interpret your results.
- Insurance Support: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The Anti-Smith (Sm) IgG Antibody Test detects autoantibodies highly specific for systemic lupus erythematosus (SLE). This quantitative ELISA assay aids clinicians in confirming a diagnosis of SLE in patients with positive antinuclear antibodies (ANA) and compatible clinical findings such as malar rash, arthritis, or unexplained fever. The test measures IgG-class antibodies against the Smith antigen complex (SmD1, SmB/B'), a nuclear ribonucleoprotein core component.
| Feature | Anti-Sm IgG ELISA (Our Test) | Closest Alternative (ENA Panel) |
|---|---|---|
| Precision | High specificity for Sm antigen (>99%) | Broad panel, lower individual specificity |
| Methodology | Enzyme-Linked Immunosorbent Assay (ELISA) | Multiplex Immunoassay (Luminex / Immunoblot) |
| Turnaround Time | Same Day (after Tue/Fri 9 AM cutoff) | 2–3 Business Days |
| Price | 130 AED | 300–400 AED |
Physician Insight & Safety Protocols
"The Anti-Smith antibody test provides a highly specific serological clue in the diagnostic workup for systemic lupus erythematosus. When I evaluate a patient presenting with joint pain, photosensitive rash, and a positive ANA, this marker helps strengthen the clinical suspicion. However, no laboratory result should replace a thorough history and physical examination — a comprehensive rheumatological assessment remains the gold standard."
Advisory — Medication Continuation
⚠️ Do not discontinue any prescribed immunosuppressive or corticosteroid therapy without direct consultation with your treating physician. Abrupt cessation may lead to disease flare or adrenal insufficiency.
Exclusion Criteria & Emergency Red Flags
Please review before scheduling
- If you currently have a high fever, acute infection, or have received a vaccination within the past 14 days, consult your physician before proceeding with the test.
- This test is not a substitute for emergency medical care. Seek immediate evaluation at a hospital emergency department if you experience severe chest pain, shortness of breath, sudden joint swelling with erythema, or new neurological symptoms such as seizures or confusion.
- Do not modify your immunosuppressive medication regimen without explicit approval from your rheumatologist or specialist.
Patient FAQ & Clinical Guidance
1. What is the Anti-Smith (Sm) IgG test used for?
This test detects IgG antibodies directed against the Smith antigen, a nuclear ribonucleoprotein complex that serves as a highly specific serological marker for systemic lupus erythematosus (SLE). It is typically ordered when a patient has a positive antinuclear antibody (ANA) test and presents with symptoms suggestive of lupus — such as joint pain, malar or discoid rash, unexplained fever, or serositis. A positive result strongly supports an SLE diagnosis, though a negative result does not exclude the disease and must be interpreted within the complete clinical context.
2. How is the test performed and what is the turnaround time?
A standard venipuncture blood sample (serum) is collected, processed via centrifugation, and analyzed using a quantitative enzyme-linked immunosorbent assay (ELISA). Results are available same day when the sample is received before the 9 AM cutoff on Tuesday or Friday. Our VIP Mobile Phlebotomy service ensures hospital-grade, cold-chain transport directly to our ISO 9001:2015 certified laboratory. A trained phlebotomist can visit your home or office between 8 AM and 11 PM, seven days a week.
3. What does a positive Anti-Smith IgG result mean for my health?
A positive Anti-Smith IgG result is more than 99% specific for systemic lupus erythematosus and is rarely observed in other autoimmune or connective tissue diseases. This means false positives are extremely uncommon. However, a positive result alone does not confirm SLE — your physician will integrate this finding with your clinical signs, additional laboratory data (e.g., anti-dsDNA, complement levels, urinalysis), and the American College of Rheumatology classification criteria before establishing a definitive diagnosis and treatment plan.
UAE Regulatory & Data Privacy Adherence
Data Protection & Clinical Governance: DNA Labs UAE operates under the strict provisions of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient health information is encrypted, access-controlled, and processed solely for diagnostic purposes with explicit consent.
Medical Liability & Patient Safety: Clinical testing procedures and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring full accountability and transparency in the delivery of diagnostic services.
Certification: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). All laboratory processes comply with international quality management standards.
Clinical & Logistical Metadata
| Test Name | Anti-Smith (Sm) IgG Antibody Test |
| Price (AED) | 130 AED |
| Turnaround Time | Same Day (after Tue/Fri 9 AM cutoff) |
| Sample Type / Matrix | Serum (Peripheral Blood) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Enzyme-Linked Immunosorbent Assay (ELISA) |
| ICD-10-CM Code | M32.9 |
| LOINC Code | 33546-4 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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