Test Price
2,800 AED✅ Home Collection Available
APOL1 Gene Susceptibility to Focal Segmental Glomerulosclerosis Type 4 (FSGS4) – Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Advanced next-generation sequencing (NGS) test detecting APOL1 risk variants (G1 and G2) associated with increased susceptibility to focal segmental glomerulosclerosis type 4 and end-stage kidney disease, particularly in individuals of African ancestry. Achieves 99.9% diagnostic sensitivity via ISO 9001:2015 certified processing. Includes VIP mobile phlebotomy with temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM, plus post-test telephonic genetic counselling. Direct insurance billing verification available via WhatsApp.
ISO 9001:2015 Certified Processing
Hospital-Grade Cold-Chain Phlebotomy
Telephonic Clinical Result Interpretation
Test Overview & Methodology
The APOL1 NGS test detects risk variants (G1 and G2) in the APOL1 gene associated with increased susceptibility to focal segmental glomerulosclerosis type 4 and end-stage kidney disease, particularly in individuals of African ancestry. This test is performed using Next Generation Sequencing technology, providing high-resolution variant calling and comprehensive coverage of the entire coding region and splice sites.
| Feature | Our Test (NGS – APOL1 Gene) | Closest Alternative (Targeted Genotyping) |
|---|---|---|
| Precision | 99.9% sensitivity for known and novel variants | Detects only predefined G1/G2 alleles; misses rare variants |
| Methodology | Next Generation Sequencing (Illumina platform) | PCR-based or Sanger sequencing (limited coverage) |
| Turnaround | 3–4 Weeks (with genetic counselling included) | 2–3 Weeks (counselling often separate) |
| Clinical Utility | Comprehensive risk stratification, research-grade data | Basic risk allele identification only |
Physician Insight & Safety Protocols
"As a clinical geneticist, I emphasize that a positive APOL1 risk allele result indicates increased susceptibility rather than a guaranteed diagnosis. The presence of two risk alleles (G1/G1, G2/G2, or G1/G2) warrants proactive renal monitoring and lifestyle modifications. Genetic counselling is essential to place these findings within the context of family history, ancestry, and renal function markers. Testing should always be paired with comprehensive pre- and post-test counselling to support informed decision-making."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Patient Safety Advisory – Exclusion Criteria & Emergency Red Flags
Do not discontinue prescribed medication without consulting your doctor. The APOL1 genetic test is not suitable for individuals without African ancestry or for evaluating non-APOL1-related nephrotic syndromes. Avoid testing during acute febrile illness that may compromise DNA quality.
Emergency red flags: sudden swelling (oedema), severe hypertension, or a sharp decrease in urine output require immediate medical attention as these may indicate acute kidney injury unrelated to the test procedure.
Paediatric consent: testing of minors requires documented parental or guardian consent in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the APOL1 gene test?
The APOL1 genetic test identifies two common risk variants, G1 and G2, that increase FSGS susceptibility. It uses next-generation sequencing to analyze the entire gene for these and any rare mutations. This helps clinicians assess the genetic risk of developing focal segmental glomerulosclerosis and associated kidney failure.
2. Who should consider this test?
Individuals of African ancestry with proteinuria, unexplained CKD, or a family history of FSGS should consider testing. Patients with collapsing glomerulopathy, HIV-associated nephropathy, or those being evaluated for kidney transplantation are also candidates. Genetic counselling before testing is strongly advised.
3. What do my results mean?
Two risk alleles (G1/G1, G2/G2, or G1/G2) indicate high risk for FSGS and kidney failure; one allele indicates moderate risk. A negative result reduces, but does not eliminate, the lifetime risk. Results should always be correlated with renal function tests, family history, and specialist evaluation. A genetic counsellor will explain your personalised risk profile.
4. How is the sample collected and what is the turnaround time?
Sample collection is performed via standard peripheral blood draw using hospital-grade cold-chain phlebotomy, available through VIP mobile home collection from 8 AM to 11 PM daily. Turnaround time is 3–4 weeks, which includes comprehensive genetic counselling following result delivery.
UAE Regulatory & Data Privacy Adherence
All genetic data is processed under the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) with end-to-end encryption and strict access controls. Health information handling complies with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. The facility is ISO 9001:2015 certified and operates under DHA Facility License Number 1143.
Clinical & Logistical Metadata
| Test Name | APOL1 Gene Susceptibility to Focal Segmental Glomerulosclerosis Type 4 (FSGS4) – NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (includes post-test genetic counselling) |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next Generation Sequencing (Illumina platform), full coding region and splice site coverage |
| ICD-10-CM Code | Z15.89, N04.1, Z84.1 |
| LOINC Code | 81968-6 – APOL1 gene variant analysis in Blood or Tissue by Sequencing |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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