PSEN1 Gene Alzheimer Disease Type 3 Genetic Test in Dubai | 2800 AED | NGS Sequencing

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next-Generation Sequencing (NGS).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Genetic Counselling for result interpretation and family risk assessment.
Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.

Test Overview & Methodology

The PSEN1 genetic test screens for pathogenic variants in the presenilin-1 gene, the most common cause of aggressive, early-onset familial Alzheimer disease type 3. Our next-generation sequencing (NGS) platform covers all coding exons at greater than 1000x depth, outperforming single-site genotyping panels in sensitivity, completeness, and classification of variants of uncertain significance. This test directly identifies hereditary mutations that confer a high lifetime risk of early-onset dementia, enabling accurate genetic counselling, family risk stratification, and targeted enrolment in clinical trials.

Feature	Our Test (DNA Labs UAE)	Closest Alternative
Precision / Methodology	NGS whole-gene sequencing (coding exons), ISO 9001:2015 accredited laboratory	Single-site genotyping or limited panel PCR, may miss rare or novel variants
Turnaround Time	3–4 Weeks (verified NGS pipeline)	4–6 Weeks (outsourced, lower priority)
Post-Test Support	Free telephonic genetic counselling and clinical guidance	Result-only report, no interpretation support

Physician Insight & Safety Protocols

“This test provides definitive genetic confirmation for early-onset familial Alzheimer disease when a pathogenic PSEN1 variant is identified. However, a positive result does not diagnose current dementia — it indicates a high lifetime risk. Every result must be integrated with neurological evaluation, family history, and psychosocial readiness assessment. I strongly advise both pre-test and post-test genetic counselling sessions to ensure patients fully understand the implications for their own health and for their biological relatives.”

— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403

Advisory Precautions

Do not discontinue or alter any prescribed medication without consulting your treating physician. Genetic test results may prompt adjustments to your care plan that should be guided by a qualified neurologist or geriatrician.

Exclusion Criteria & Emergency Red Flags

This test is not a substitute for a full diagnostic dementia workup in individuals already exhibiting cognitive symptoms; it should be combined with amyloid PET imaging or CSF biomarker analysis if clinically indicated.
Not recommended for asymptomatic minors (0–17 years) as predictive testing for adult-onset conditions without established therapeutic intervention, consistent with international clinical genetics guidelines.
If you experience severe anxiety, depression, or suicidal ideation after receiving your results, seek immediate assistance from a mental health professional or call emergency services (UAE: 997).

Patient FAQ & Clinical Guidance

1. What is the clinical purpose of the PSEN1 gene test, and how does it influence my care plan?

This test directly identifies pathogenic variants in the PSEN1 gene that cause aggressive early-onset Alzheimer disease type 3, enabling accurate genetic counselling, family risk stratification, and early multi-disciplinary surveillance planning. A positive finding confirms the hereditary form and supports targeted enrolment in clinical trials for emerging therapies.

2. Can this test be performed on a dry blood spot, and how does the sample collection work at home?

Yes, the laboratory accepts one drop of blood on an FTA card, extracted DNA, or whole blood in an EDTA tube. Our VIP mobile phlebotomy team performs a painless finger-prick or venous draw during a home visit scheduled between 8 AM and 11 PM, using a temperature-controlled cold-chain transport kit that preserves DNA integrity for high-quality NGS analysis.

3. Is this test covered by UAE health insurance, and what steps are needed for approval?

Coverage depends on individual policy terms and clinical necessity. We provide direct billing verification: simply send your Emirates ID and insurance card photo via WhatsApp to +971 54 548 8731, and our team will check eligibility and obtain prior authorization from your insurer before scheduling your sample collection.

4. What does a negative result mean, and could a variant of uncertain significance be reported?

A negative result means no pathogenic variant was detected in the PSEN1 gene, though it does not rule out all genetic causes of early-onset Alzheimer disease (other genes such as PSEN2 and APP are not covered in this single-gene test). A variant of uncertain significance (VUS) may be reported; in such cases, our genetic counsellor will discuss segregation studies and reclassification options with your consent.

UAE Regulatory & Data Privacy Adherence

Regulatory Compliance Framework

DNA Labs UAE operates under the regulatory oversight of the Dubai Health Authority (DHA Facility License Number: 1143). All genetic data handling, storage, and processing strictly adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent protocols comply with Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information is encrypted, access-controlled, and never shared with third parties without your explicit written consent.

Clinical & Logistical Metadata

Test Name	PSEN1 Gene Alzheimer Disease Type 3 Genetic Test (NGS Sequencing)
Price (AED)	2,800 AED
Turnaround Time	3–4 Weeks
Sample Type / Matrix	Whole Blood (EDTA), DNA Extract, or FTA Card Dried Blood Spot
Methodology Used	Next-Generation Sequencing (NGS) – Full Coding Exon Coverage >1000x Depth
ICD-10-CM Code	G30.0 (Alzheimer disease with early onset)
LOINC Code	94291-1 (PSEN1 gene mutation analysis in Blood or Tissue by Sequencing)
DHA Facility License & Laboratory Address	License No. 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE

دعم ثنائي اللغة متاح

التحقق من التغطية التأمينية

Check Insurance Coverage Instantly

Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.

توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.

✅ DHA Certified ✅ ISO 15189 ✅ HIPAA Compliant

💬 التحقق عبر الواتساب Verify via WhatsApp 📞 Call Team

Available in Arabic, English, Hindi & Urdu

🏅

ISMS 27001:2022

📋

ISO Accredited

🔒

HIPAA

All reports reviewed by DHA-Certified physicians