Test Price
340 AEDโ Home Collection Available
17-Hydroxyprogesterone (17-OHP) Stimulation by ACTH Test in Dubai | 340 AED | DHA Licensed
Executive Summary & Core Metrics
Clinical Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Transport and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Compliance: Strictly adheres to UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. ISO 9001:2015 Certified (INT/EGQ/2509DA/3139). DHA Facility License No: 1143. Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Test Overview & Methodology
ACTH Stimulation Panel for 17-OHP Determination
The 17-Hydroxyprogesterone (17-OHP) stimulation by ACTH test is a dynamic endocrine evaluation that assesses adrenal cortex function by measuring 17-OHP concentrations before and after administration of synthetic ACTH (Synacthen). This is the gold-standard diagnostic procedure for Congenital Adrenal Hyperplasia (CAH), specifically 21-hydroxylase deficiency, and other enzyme defects in the steroidogenic pathway. The baseline serum sample is drawn at 08:00, followed by intravenous ACTH administration, and a second sample collected at 60 minutes post-stimulation. The laboratory employs Radioimmunoassay (RIA) with HPLC purification, validated against international reference standards to ensure superior precision and specificity exceeding 95%.
| Feature | Details |
|---|---|
| Primary Condition | Congenital Adrenal Hyperplasia (21-hydroxylase deficiency) โ ICD-10-CM: E25.0 |
| Methodology | Radioimmunoassay (RIA) with HPLC purification |
| Turnaround Time | 1 week (standard) |
| Sample Requirements | Two timed serum samples (baseline + 60 min post-ACTH) |
Physician Insight & Safety Protocols
โThe 17-OHP stimulation test provides indispensable enzymatic clarity for diagnosing Congenital Adrenal Hyperplasia, directly guiding intervention decisions in both pediatric and adult populations. However, its value emerges only when interpreted alongside the complete clinical picture, including electrolyte status and CYP21A2 molecular results. Patients must never alter their corticosteroid regimen based solely on test findings; such changes require explicit specialist oversight.โ
โ Dr. Ajay Singh, General Practitioner (DHA Registration ID: 36234132)
Medication Safety Advisory
โผ Critical Medication Warning: Do not discontinue or adjust prescribed glucocorticoid or mineralocorticoid therapy without consulting your doctor. Abrupt cessation of these medications can trigger a life-threatening adrenal crisis, especially in patients with known 21-hydroxylase deficiency.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Known hypersensitivity to ACTH (Synacthen); active untreated systemic infection; recent corticosteroid use within 48 hours; uncontrolled severe hypertension; pregnancy (unless specifically indicated by a specialist); current acute adrenal crisis symptoms (hypotension, shock, altered consciousness).
- ER Red Flags During/After Test: Sudden severe hypotension, syncope, respiratory distress, anaphylaxis, or signs of acute adrenal insufficiency โ call 998 immediately and notify your supervising physician.
- Precautions: Always perform the test under clinical supervision. Ensure IV access and emergency hydrocortisone availability. Monitor vital signs throughout the procedure.
Patient FAQ & Clinical Guidance
1. Why is the 17-OHP stimulation by ACTH test needed?
The 17-OHP stimulation test is the definitive diagnostic procedure for Congenital Adrenal Hyperplasia (CAH). It is essential when newborn screening results, ambiguous genitalia in infants, unexplained hirsutism, or infertility in adults suggest a steroidogenic enzyme defect. A baseline 17-OHP level alone cannot distinguish between classic and non-classic forms of CAH. The stimulated value measured 60 minutes after ACTH administration quantifies the degree of 21-hydroxylase impairment, which is critical for guiding glucocorticoid and mineralocorticoid replacement therapy, as well as genetic counseling for affected families.
2. How do I prepare for the test and what happens during collection?
Preparation requires an overnight fast of 8โ12 hours. You should arrive at our collection center between 8:00 and 10:00 AM, or schedule our mobile phlebotomist for a home visit. Water is permitted. A baseline blood sample is drawn from a vein in your arm. A small, precisely measured dose of synthetic ACTH (Synacthen) is then administered intravenously. You will rest comfortably for 60 minutes with close monitoring of vital signs. A second blood sample is then collected. For females of reproductive age, the test is ideally scheduled within the first 10 days of the menstrual cycle to avoid hormonal variation. Both samples are handled under strict cold chain conditions and sent to our ISO-accredited laboratory for analysis.
3. What do my results mean and how are they interpreted?
Elevated 17-OHP levels 60 minutes after ACTH stimulation confirm 21-hydroxylase deficiency. Normative cut-off values depend on age, sex, and the specific assay used. Generally, a stimulated 17-OHP level greater than 10 ng/mL is highly suggestive of classic CAH, while levels between 2 and 10 ng/mL may indicate a non-classic form. Your endocrinologist will interpret the results alongside your clinical features, serum electrolyte panel, and, when indicated, CYP21A2 gene sequencing. Borderline results may require a repeat test or more extensive stimulation protocols. Never self-interpret adrenal function test results; always discuss them with a DHA-licensed specialist to ensure appropriate, personalized medical management.
UAE Regulatory & Data Privacy Adherence
Patient Data Protection & Compliance Framework
DNA Labs UAE operates in full compliance with UAE data protection and health information governance laws. All personal health data collected during the 17-OHP stimulation testing process is processed in strict accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. No patient information is shared with third parties without explicit written consent, except as required by law. Our laboratory adheres to ISO 9001:2015 quality management standards (Cert: INT/EGQ/2509DA/3139) to ensure secure handling and storage of all clinical data. Medical liability and patient safety are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring that all procedures are conducted with the highest standard of care.
Clinical & Logistical Metadata
| Test Name | 17-Hydroxyprogesterone (17-OHP) Stimulation by ACTH |
| Price (AED) | 340 |
| Turnaround Time | 1 week (standard) |
| Sample Type / Matrix | Two timed serum samples (baseline + 60 min post-ACTH) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Radioimmunoassay (RIA) with HPLC purification |
| ICD-10-CM Code | E25.0 |
| LOINC Code | 27140-8 |
| DHA Facility License & Laboratory Address | DNA Labs UAE โ DHA License 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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