ACTIVATED PROTEIN C – RESISTANCE APCR Test
At DNA Labs UAE, we offer the ACTIVATED PROTEIN C – RESISTANCE APCR Test for the diagnosis of Factor V Leiden mutation. This genetic disorder increases the risk of developing abnormal blood clots in veins, known as venous thromboembolism.
Test Details
The APCR test measures the ability of activated protein C (APC) to inactivate Factor V, a clotting protein in the blood. Individuals with Factor V Leiden mutation have a specific mutation in the Factor V gene, making Factor V resistant to inactivation by APC. This leads to an increased risk of blood clot formation.
During the APCR test, a blood sample is taken from the patient and mixed with a substance that activates the clotting process. The sample is then treated with APC, and the time it takes for the clot to form is measured. If the clotting time is not prolonged after the addition of APC, it indicates that the patient has Factor V Leiden mutation and is resistant to the inactivation of Factor V by APC.
Test Components and Price
The ACTIVATED PROTEIN C – RESISTANCE APCR Test costs AED 920.0. The test requires a sample of 3 mL whole blood in 1 Blue Top (Sodium Citrate) tube. It is recommended to mix the sample thoroughly by inversion and transport it to the lab within 4 hours. If immediate transport is not possible, the sample can be processed to make Platelet Poor Plasma (PPP) within 1 hour of collection. The sample should be frozen immediately and shipped frozen without thawing.
Pre Test Information
Prior to sampling, it is recommended that the patient discontinues Heparin for 1 day and Oral Anticoagulants for 7 days, as these drugs may affect test results. Discontinuation should be done with prior consent from the treating Physician. A duly filled Coagulation Requisition Form (Form 15) is mandatory for the test.
Report Delivery
The sample for the ACTIVATED PROTEIN C – RESISTANCE APCR Test should be collected by Wednesday at 11am, and the report will be delivered the next day.
Test Type and Doctor
The ACTIVATED PROTEIN C – RESISTANCE APCR Test falls under the category of Thromboembolic Disorders. It is recommended to consult a Hematologist for this test.
Additional Information
A negative APCR test does not rule out the presence of other genetic or acquired risk factors for blood clotting disorders. Therefore, additional tests may be required to fully evaluate the risk of blood clot formation in an individual.
For more information or to schedule an appointment, please contact DNA Labs UAE.
| Test Name | ACTIVATED PROTEIN C – RESISTANCE APCR Test |
|---|---|
| Components | |
| Price | 920.0 AED |
| Sample Condition | 3 mL whole blood in 1 Blue Top (Sodium Citrate) tube. Mix thoroughly by inversion. Transport to Lab within 4 hours. If this is not possible, make PPP within 1 hour of collection as follows:Centrifuge sample at 3600 rpm for 15 min. & transfer supernatant to a clean plastic tube. Centrifuge this supernatant again at 3600 rpm for 15 mins. & finally transfer the supernatant (PPP) to 1 labelled, clean plastic screw capped vial.FREEZE IMMEDIATELY. Ship frozen. DO NOT THAW. Overnight fasting is preferred. Duly filled Coagulation Requisition Form (Form 15)is mandatory. |
| Report Delivery | SampleWed by 11am; Report Next day |
| Method | Electromechanical Clot Detection |
| Test type | Thromboembolic Disorders |
| Doctor | Hematologist |
| Test Department: | |
| Pre Test Information | Duly filled Coagulation Requisition Form (Form 15) is mandatory. It is recommended that patient discontinues Heparin for 1 day and Oral Anticoagulants for 7 days prior to samplingas these drugs may affect test results. Discontinuation should be with prior consent from the treating Physician. |
| Test Details |
Activated Protein C Resistance (APCR) test is a laboratory test used to diagnose a condition called Factor V Leiden mutation. Factor V Leiden mutation is a genetic disorder that increases the risk of developing abnormal blood clots in veins, a condition known as venous thromboembolism. APCR test measures the ability of activated protein C (APC) to inactivate Factor V, a clotting protein in the blood. Normally, APC breaks down Factor V, preventing excessive clotting. However, individuals with Factor V Leiden mutation have a specific mutation in the Factor V gene, which makes Factor V resistant to inactivation by APC. This leads to an increased risk of blood clot formation. During the APCR test, a blood sample is taken from the patient and mixed with a substance that activates the clotting process. The sample is then treated with APC, and the time it takes for the clot to form is measured. If the clotting time is not prolonged after the addition of APC, it indicates that the patient has Factor V Leiden mutation and is resistant to the inactivation of Factor V by APC. The APCR test is primarily used to confirm the diagnosis of Factor V Leiden mutation in individuals with a personal or family history of blood clots. It is also performed in certain situations, such as before starting oral contraceptives or hormone replacement therapy, before surgery, or in pregnant women with a history of blood clots. It is important to note that a negative APCR test does not rule out the presence of other genetic or acquired risk factors for blood clotting disorders. Therefore, additional tests may be required to fully evaluate the risk of blood clot formation in an individual. |
