Test Price
2,800 AED✅ Home Collection Available
SERPINA1 Gene (Alpha-1 Antitrypsin Deficiency) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SERPINA1 (نقص ألفا-1 أنتيتريبسين) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Clinical Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Laboratory (Cert: INT/EGQ/2509DA/3139). Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy across all Emirates. Post-Test Clinical Guidance: Complimentary telephonic interpretation session with a DHA-licensed molecular biologist to explain your results in clinical context. Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
الضمان السريري: حساسية تشخيصية 99.9% عبر مختبر الجيل التالي للتسلسل المعتمد بموجب ISO 9001:2015. الخدمات اللوجستية المتميزة: خدمة سحب الدم المنزلية عبر فريق تمريضي متنقل مع نقل مبرد معتمد. الاستشارة بعد الفحص: جلسة هاتفية مجانية مع أخصائي جينات مرخص لتفسير النتائج وتوصيات المتابعة.
Comprehensive NGS Analysis of the SERPINA1 Gene
The SERPINA1 gene encodes alpha-1 antitrypsin (AAT), a critical protease inhibitor protecting lung and liver tissue. This next‑generation sequencing test sequences the entire coding region and splice sites to detect pathogenic variants causing alpha‑1 antitrypsin deficiency (AATD), a hereditary condition associated with early‑onset emphysema and chronic liver disease. Ideal for symptomatic patients, family screening, and pre‑conception risk assessment.
| Feature | Our Test (NGS) | Conventional Genotyping |
|---|---|---|
| Detection Scope | >99% of clinically relevant variants (coding + splice) | Limited to common Pi*S & Pi*Z alleles only |
| Diagnostic Sensitivity | 99.9% | ~70% for rare/null alleles |
| Turnaround Time | 3–4 weeks | 1–2 weeks |
| Sample | Whole Blood / DNA FTA Card / Extracted DNA | Whole Blood only |
Physician Insight & Safety Protocol
“A positive result does not confirm disease onset but mandates a thorough clinical evaluation. I recommend that all results be correlated with serum AAT levels, pulmonary function tests, and liver elastography. Genetic counselling is essential for family planning.”
— Dr. Prabhakar Reddy, DHA License 61713011
⚠ Medication Safety
Do not discontinue prescribed medication (e.g., bronchodilators, ursodeoxycholic acid) without consulting your treating physician. Genetic findings guide risk but never replace ongoing symptom management.
Exclusion Criteria & Emergency Red Flags
- Inability to provide a blood or DNA sample due to severe coagulopathy (uncorrected INR >3.0).
- Active febrile illness requiring urgent clinical attention—defer test until stable.
- Minors without legal guardian consent (as per UAE CDS Law 2026).
- Seek immediate emergency care if you experience sudden severe shortness of breath, jaundice with confusion, or massive ascites—these are not related to sample collection but may signal decompensated AATD liver or lung disease.
Patient FAQ & Clinical Guidance
1. What does the SERPINA1 genetic test detect, and how does it work?
This test uses next‑generation sequencing to identify DNA variants in the entire SERPINA1 coding region and flanking splice sites, delivering a comprehensive assessment of alpha‑1 antitrypsin deficiency risk.
يكشف هذا الاختبار جميع الطفرات الجينية في جين SERPINA1 لتحديد خطر نقص ألفا-1 أنتيتريبسين، مما يساعد الأطباء في التشخيص المبكر والتخطيط العائلي.
2. Do I need to stop any medications or supplements before the sample collection?
No medication adjustment is required; this is a DNA-based test unaffected by drugs, diet, or supplements—simply provide a blood or FTA card sample at your convenience.
لا داعي لإيقاف أي أدوية أو مكملات قبل سحب العينة، فالفحص جيني ولا يتأثر بالعلاجات الحالية.
3. How should I interpret a “variant of uncertain significance” (VUS) result?
A VUS does not confirm disease and must be interpreted with family history and serum AAT levels—our DHA‑licensed genetic counsellors explain all findings during a dedicated post‑ call.
النتيجة غير المؤكدة لا تعني الإصابة بالمرض؛ ننصح بتقييم شامل مع أخصائي الوراثة وفحوصات ألفا-1 أنتيتريبسين في الدم.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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