Test Price
2,800 AED✅ Home Collection Available
CXCR4 Gene WHIM Syndrome Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Precision: 99.9% Diagnostic Sensitivity via ISO Accredited NGS Processing covering all coding exons and splice sites.
- Convenience: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Expert Guidance: Complimentary Post-Test Telephonic Clinical Guidance for result interpretation with a Consultant Medical Geneticist.
- Insurance: Instant Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The CXCR4 Gene WHIM Syndrome Genetic Test is a comprehensive next-generation sequencing (NGS) assay that analyzes the entire coding region of the CXCR4 gene for pathogenic variants linked to Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome. This test provides a definitive molecular diagnosis for this rare primary immunodeficiency and guides targeted immune management and family cascade screening.
| Feature | Our Test (NGS Full Gene) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Detection Scope | All coding exons + splice sites | Targeted known mutations only |
| Sensitivity | >99.9% for single nucleotide variants and indels | ~95% (misses novel variants) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Methodology | Next-Generation Sequencing (NGS) | Sanger Sequencing |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I understand the complexity and emotional weight that accompanies genetic testing for rare immunodeficiency syndromes. A positive CXCR4 variant requires careful correlation with clinical and immunological phenotypes; not all variants are pathogenic. I strongly recommend that patients and their families engage with a specialized immunologist and a certified genetic counsellor to fully contextualize the results and develop a tailored management plan.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
⚠️ Important Clinical Advisory
A WHIM syndrome diagnosis does not automatically justify changes to your current treatment regimen. Never discontinue or modify prescribed immunomodulatory therapy, prophylactic antibiotics, or immunoglobulin replacement without explicit consultation with your supervising physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Recent blood transfusion (within 4 weeks) may cause DNA chimerism and affect test accuracy. Defer testing until 4 weeks post-transfusion.
- Exclusion: Asymptomatic individuals without a documented family history or strong clinical suspicion of WHIM syndrome are not routine candidates for this test.
- ER Red Flag: If you experience severe recurrent infections, high fever, rigors, or signs suggestive of sepsis while awaiting results, seek emergency medical care immediately.
Patient FAQ & Clinical Guidance
1. What is the CXCR4 WHIM syndrome genetic test used for?
This single-gene NGS test detects pathogenic mutations in the CXCR4 gene to confirm or rule out a diagnosis of WHIM syndrome. Results guide immunology management, infection prophylaxis strategy, and targeted family screening for at-risk relatives.
2. How is the sample collected for this NGS test?
Collection is straightforward and minimally invasive using a standard peripheral blood draw (5 mL in EDTA tube). Alternatively, extracted genomic DNA or a dried blood spot on an FTA card can be accepted. Our VIP Mobile Phlebotomy service can perform the draw at your home or office between 8 AM and 11 PM daily.
3. How long does it take to get results, and what is the price in the UAE?
Results are reported within 21–28 calendar days (3–4 weeks). The all-inclusive cost is 2,800 AED, which covers the full gene sequencing, bioinformatics analysis, and a complimentary post-test telephonic genetic counselling session.
4. Is genetic counselling included with this test?
Yes. Every report is accompanied by a complimentary telephonic consultation with a qualified genetic counsellor to explain your results, discuss inheritance patterns, and outline surveillance recommendations for family members.
UAE Regulatory & Data Privacy Adherence
Your genetic data is handled with the highest standards of confidentiality and security in full compliance with UAE federal health data frameworks:
- Data Protection: Governed by Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) ensuring your genomic information is processed lawfully, transparently, and securely.
- Health Information Governance: Compliant with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, which mandates strict controls on electronic health data storage, transfer, and access.
- Clinical Safety & Consent: Diagnostic testing procedures and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, safeguarding your rights throughout the care pathway.
Clinical & Logistical Metadata
| Test Name | CXCR4 Gene WHIM Syndrome Genetic Test (NGS Full Gene Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21 – 28 Calendar Days (3–4 Weeks) |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), Extracted Genomic DNA, or FTA Card Dried Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina Platform, Full Coding Exons & Splice Sites |
| ICD-10-CM Code | D81.8 (Other Combined Immunodeficiencies) |
| LOINC Code | 82939-0 (CXCR4 gene sequence analysis) |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians