Test Price
550 AED✅ Home Collection Available
HE4 (Human Epididymis Protein 4) Test in UAE | 550 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
- ✓ Diagnostic Accuracy: High specificity for epithelial ovarian cancer risk assessment and monitoring, validated through ISO 9001:2015 accredited processing (Cert INT/EGQ/2509DA/3139).
- ✓ Premium Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across all UAE emirates.
- ✓ Clinical Guidance: Post-test telephonic result interpretation provided by DHA-licensed specialists.
- ✓ Insurance Direct Billing: Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The HE4 (Human Epididymis Protein 4) test is a serum tumor marker used primarily for monitoring and risk stratification of epithelial ovarian cancer. It provides superior specificity compared to CA-125 in premenopausal women and is a core component of the Risk of Ovarian Malignancy Algorithm (ROMA). The test employs Chemiluminescent Microparticle Immunoassay (CMIA) technology for quantitative detection of HE4 protein in peripheral blood.
| Parameter | HE4 Test | CA-125 Alternative |
|---|---|---|
| Methodology | CMIA (Chemiluminescent Microparticle Immunoassay) | Immunoassay (various platforms) |
| Ovarian Cancer Specificity | Higher specificity; minimally affected by endometriosis or menstrual phase | Elevated in many benign gynecologic conditions; reduced specificity |
| Turnaround Time | Same-day reporting for samples received by 4 PM Monday and Thursday | Typically 1–3 business days |
| Sample Requirement | 2 mL serum from 1 SST tube; refrigerated or frozen transport | Similar serum collection protocol |
Physician Insight & Safety Protocols
Mr. Prabhakar Reddy Kalathoor | Specialist Diagnostic Radiology | DHA Registration ID: 61713011
“I recognize that awaiting a tumor marker result can create considerable anxiety. The HE4 value must always be interpreted alongside pelvic imaging, full clinical history, and complementary biomarkers such as CA-125. It should never be used in isolation to establish a diagnosis. I strongly advise patients to review all results with their treating physician before making any clinical decisions.”
Advisory: Medication Continuity
Do not alter, pause, or discontinue any prescribed medications or treatment regimens based solely on this laboratory result without explicit direction from your managing physician. Laboratory values represent one data point in a comprehensive clinical assessment.
Exclusion Criteria & Urgent Warning Signs
- This test is not recommended for pregnant individuals or children under 18 without prior specialist consultation.
- Results may be unreliable in the setting of acute pelvic inflammatory disease or active systemic infection.
- Immediate Medical Attention Required: If you experience sudden severe abdominal or pelvic pain, unexplained rapid weight loss, persistent bloating, or difficulty eating, seek emergency care without delay. Do not wait for laboratory results.
Patient FAQ & Clinical Guidance
1. What is a normal HE4 level and what does an elevated result mean?
A normal HE4 level is generally below 150 pmol/L, though reference ranges vary by age, menopausal status, and laboratory platform. An elevated result may indicate the need for further evaluation for ovarian malignancy, but it must be interpreted within the Risk of Ovarian Malignancy Algorithm (ROMA) alongside imaging findings. An elevated level alone is not diagnostic of cancer.
2. How should I prepare for the HE4 blood test?
No special preparation is required. Fasting is not necessary, and you may continue taking all prescribed medications as directed by your physician. Inform the phlebotomist of any anticoagulant therapy.
3. Is home sample collection available for the HE4 test in Dubai and Abu Dhabi?
Yes, our ISO-certified VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection service operates daily from 8 AM to 11 PM across all UAE emirates. Samples collected by 4 PM on Monday or Thursday qualify for same-day reporting.
4. Can I take this test alongside CA-125 for ovarian cancer screening?
Yes. The combination of HE4 and CA-125, calculated through the ROMA algorithm, improves diagnostic accuracy for epithelial ovarian cancer compared to either marker alone. Discuss with your gynecologist or oncologist whether this dual-testing approach is appropriate for your clinical scenario.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance
DNA Labs UAE operates under the regulatory oversight of the Dubai Health Authority (DHA Facility License No. 1143) and adheres to the highest standards of patient data confidentiality and clinical safety. All laboratory operations comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for secure handling of personal health information, and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields which governs the electronic exchange of medical records. Clinical testing safety, informed consent protocols, and patient rights are maintained in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. Our ISO 9001:2015 quality management system (Cert INT/EGQ/2509DA/3139) ensures rigorous validation of all diagnostic procedures.
Clinical & Logistical Metadata
| Test Name | HE4 (Human Epididymis Protein 4) Test |
| Price (AED) | 550 |
| Turnaround Time | 1–2 Business Days |
| Sample Type / Matrix | Serum (2 mL from 1 SST tube) |
| Methodology Used | CMIA (Chemiluminescent Microparticle Immunoassay) |
| ICD-10-CM Code | Z12.73 |
| LOINC Code | 47213-1 |
| DHA Facility License & Laboratory Address | License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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