Test Price
750 AED✅ Home Collection Available
Des-Gamma-Carboxy Prothrombin (DCP)/PIVKA-II Serum Test in UAE | 750 AED | 2026 DHA Guidelines
تحليل ديس-غاما-كربوكسي بروثرومبين (DCP/PIVKA-II) في الإمارات | 750 درهم | معتمد من هيئة الصحة بدبي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: Paid Hospital-Grade Home Collection via ISO-Certified Cold-Chain and VIP Mobile Phlebotomy.
Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed specialists.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
ملخص تنفيذي: اختبار مصلي عالي الحساسية لقياس البروثرومبين غير الكربوكسيلي (PIVKA-II) لتشخيص ومتابعة سرطان الخلايا الكبدية، مع سحب منزلي آمن ومعايير جودة معتمدة من هيئة الصحة بدبي.
Test Overview
The Des-Gamma-Carboxy Prothrombin (DCP)/PIVKA-II serum test is a highly specific tumor marker used primarily for the detection and monitoring of hepatocellular carcinoma (HCC), particularly in high-risk patients with chronic liver disease. It provides complementary information to alpha-fetoprotein (AFP) and enhances diagnostic accuracy.
يقيس اختبار ديس-غاما-كربوكسي بروثرومبين (DCP/PIVKA-II) البروثرومبين غير الطبيعي الذي ينتجه الورم، ويُعد مؤشراً حيوياً مساعداً لتشخيص سرطان الكبد ومتابعة الاستجابة للعلاج.
| Feature | Our Test (DCP/PIVKA-II) | Closest Alternative (AFP Alone) |
|---|---|---|
| Precision | Chemiluminescent Microparticle Immunoassay (CMIA) – coefficient of variation <5% | Immunoassay with variable sensitivity (50-60% for HCC) |
| Methodology | Fully automated CMIA, ISO-certified lab, validated against LC-MS/MS reference | Standard ELISA/CMIA, higher false-positive rate |
| Turnaround Time | Same-day report if sample received by 9 AM | 24–48 hours typical |
| Clinical Utility | Independent of liver function, detects early HCC with >90% specificity | Influenced by pregnancy, liver regeneration, false positives in cirrhosis |
Physician Insight & Safety Protocol
“As a DHA-licensed Clinical Pathologist, I underscore that DCP/PIVKA-II results are never diagnostic in isolation; they must be interpreted alongside imaging, AFP, and full clinical history. A normal value does not exclude hepatocellular carcinoma, especially in early-stage disease, and any abnormal result necessitates urgent hepatology consultation. I strongly advise patients to maintain open communication with their treating oncologist or gastroenterologist for a comprehensive risk assessment.”
— Dr. PRABHAKAR REDDY, Clinical Pathologist & Laboratory Director (DHA License: 61713011)
⚠️ Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Abrupt cessation of anticoagulants, vitamin K antagonists, or chemotherapy agents can be life-threatening.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Home collection is not available for patients with current active bleeding, hemodynamic instability, or known severe platelet dysfunction.
- Exclusion: Recent high-dose vitamin K supplementation (within 7 days) may falsely lower levels; please inform the phlebotomist.
- Red Flag: Seek immediate emergency care if you experience sudden severe right upper abdominal pain, jaundice, or vomiting of blood after the test.
- Red Flag: A markedly elevated DCP (>100 ng/mL) in a patient with known cirrhosis demands urgent oncologic evaluation within 48 hours.
Pre-Test Preparation
Provide a brief clinical history including liver disease etiology, recent imaging, and current medications. Sample: 2 mL (0.5 mL min.) serum from one SST, shipped refrigerated or frozen. No fasting required unless combined with other tests.
Patient FAQ & Clinical Guidance
Q: What exactly does the DCP/PIVKA-II serum test measure and why is it ordered?
A: This test quantifies abnormal des-gamma-carboxy prothrombin produced by hepatocellular carcinoma cells, enabling early cancer detection and monitoring of treatment response. DCP/PIVKA-II is a prothrombin precursor that lacks normal carboxylation due to vitamin K absence; it is secreted by malignant hepatocytes. Physicians order this test when AFP is inconclusive or to improve diagnostic sensitivity for HCC, especially in patients with cirrhosis or chronic hepatitis B/C.
س: ما الذي يقيسه اختبار DCP/PIVKA-II ولماذا يُطلب؟
ج: يقيس هذا الاختبار البروثرومبين غير الطبيعي الذي تنتجه خلايا سرطان الكبد، مما يساعد على الكشف المبكر ومراقبة الاستجابة للعلاج. يُستخدم عندما تكون نتائج الـ AFP غير حاسمة، وخاصة لدى مرضى التشمع الكبدي أو التهابات الكبد المزمنة بفيروسي B وC.
Q: How should I prepare for the DCP/PIVKA-II blood draw and when will I receive results?
A: No special fasting is required; simply provide a short clinical history and medication list – results are delivered same-day if collected by 9 AM. The test is performed on a standard serum sample collected via our ISO-certified cold-chain home service. We recommend withholding vitamin K supplements for 24 hours prior only if medically safe. Our lab processes specimens immediately upon arrival, and you will receive a secure digital report with DHA-compliant commentary.
س: كيف أستعد لسحب الدم لفحص DCP/PIVKA-II ومتى تظهر النتائج؟
ج: لا حاجة للصيام، فقط قدّم تاريخًا سريريًا موجزًا وقائمة الأدوية – تصلك النتيجة في نفس اليوم إذا تم السحب قبل 9 صباحًا. يتم السحب المنزلي عبر سلسلة تبريد معتمدة، ويُفضّل إيقاف مكملات فيتامين ك لمدة 24 ساعة بعد استشارة الطبيب.
Q: Can a normal DCP/PIVKA-II level completely rule out liver cancer?
A: No, a normal DCP/PIVKA-II result does not exclude hepatocellular carcinoma because early-stage tumors may not secrete sufficient marker, necessitating regular imaging and AFP surveillance. False negatives occur in up to 30% of small HCCs. Therefore, this is part of a multimodal screening strategy that includes abdominal ultrasound and AFP every 6 months for at-risk individuals. Always discuss your risk profile with a gastroenterologist or oncologist.
س: هل النتيجة الطبيعية لـ DCP/PIVKA-II تستبعد سرطان الكبد تمامًا؟
ج: لا، النتيجة الطبيعية لا تستبعد وجود سرطان الكبد، خاصة في المراحل المبكرة، لأن الورم قد لا يفرز كمية كافية من العلامة – لذا يجب المتابعة الدورية بالتصوير و AFP. تحدث السلبيات الكاذبة في 30% من الحالات الصغيرة، ولا غنى عن التقييم السريري المتكامل.
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