Test Price
2,800 AED✅ Home Collection Available
THRB Gene Thyroid Hormone Resistance Genetic Test in UAE | 2800 AED | DHA Guideline Compliant
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity achieved via ISO 9001:2015 Accredited Genetic Test identifies pathogenic variants in the THRB gene, enabling precise diagnosis of resistance to thyroid hormone (RTH) and guiding personalized endocrine management.
Premium Logistics: Hospital‑Grade Home Collection via ISO Certified Cold‑Chain Home Collection & VIP Mobile Phlebotomy (available daily 8 AM – 11 PM). Telephonic Post‑Test Clinical Guidance on result interpretation included. Direct Billing Verification via WhatsApp: +971 54 548 8731.
Price: 2,800 AED | Turnaround Time: 3–4 Weeks (21–28 Business Days) | Methodology: Next Generation Sequencing (NGS)
Test Overview & Methodology
The THRB gene test screens for germline mutations causing resistance to thyroid hormone (RTH), a rare autosomal dominant disorder. Performed on whole blood (EDTA), FTA card, or pre‑extracted DNA, this NGS‑based assay ensures >99% coverage of coding regions and splice sites, delivering definitive results within 3–4 weeks for accurate endocrinological counselling.
| Feature | Our THRB NGS Test | Standard Single‑Gene Testing |
|---|---|---|
| Analytical Precision | 99.9% sensitivity & specificity (NGS deep coverage) | ~95% (PCR & Sanger only) |
| Methodology | Next Generation Sequencing (NGS) with deletion/duplication analysis | Sanger sequencing of select exons |
| Turnaround Time | 3–4 weeks with genetic counselling add‑on | 6–8 weeks, often without clinical interpretation |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I emphasize that a positive THRB variant must be correlated with thyroid function tests, pituitary imaging, and family history. This test is not a standalone diagnostic; it clarifies the molecular aetiology of abnormal TSH and free T4 levels, empowering tailored therapy decisions.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Safety Advisory
Do not discontinue prescribed thyroid medication, beta‑blockers, or any hormone therapy without consulting your endocrinologist. Test results require expert clinical correlation.
Exclusion Criteria & Emergency Red Flags
- Age below 18 without legal guardian consent (per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability and UAE Personal Data Protection Law).
- Patient presenting with acute thyroid storm symptoms (tachycardia >140 bpm, hyperthermia, altered mental status) – immediate emergency care required.
- Uncontrolled cardiovascular instability or recent myocardial infarction.
- Inability to provide a valid clinical history or pedigree chart as required for pre‑test genetic counselling.
Patient FAQ & Clinical Guidance
1. What does the THRB gene test check, and how long until I receive my report?
This NGS analysis comprehensively examines the entire coding region of the THRB gene within 3–4 weeks, providing a definitive answer on whether a pathogenic variant is responsible for your thyroid hormone resistance, thereby guiding targeted endocrine interventions.
2. Is home sample collection really safe and DHA‑approved in the UAE?
Absolutely. Our ISO‑certified phlebotomists follow strict cold‑chain protocols and adhere to UAE PDPL data privacy law (Federal Decree-Law No. 45 of 2021) and Federal Law No. 2 of 2019, ensuring your blood, DNA, or FTA card sample is collected securely at your doorstep between 8 AM and 11 PM and transported directly to our CAP‑accredited facility.
3. Will my insurance cover this genetic test, and how can I verify instantly?
Coverage depends on your plan’s genetic testing benefits; we provide a direct billing verification service via WhatsApp at +971 54 548 8731—simply share your Emirates ID and policy number, and our team will confirm eligibility before your appointment without any upfront payment for pre‑approved cases.
UAE Regulatory & Data Privacy Adherence
UAE Regulatory & Compliance Notice
This service is provided under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All laboratory processing adheres to ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139). Genetic counselling is mandatory prior to testing; a pedigree chart must be submitted with the request. Minors (under 18) require a legal guardian’s explicit consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | THRB Gene Full Mutation Analysis (Resistance to Thyroid Hormone) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (21–28 Business Days) |
| Sample Type / Matrix | Whole Blood (EDTA), FTA Card, or Extracted DNA |
| Methodology Used | Next Generation Sequencing (NGS) with deletion/duplication analysis |
| ICD-10-CM Code | E07.8 (Other specified disorders of thyroid) |
| LOINC Code | 21670-1 (THRB gene full mutation analysis) |
| DHA Facility License & Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians