Test Price
2,800 AED✅ Home Collection Available
THRA Gene Hypothyroidism Congenital Non-Goitrous Type 6 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين THRA لقصور الغدة الدرقية الخلقي غير الدرقي من النوع السادس بتقنية التسلسل الجيني المتقدم في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Overview: Precision Genetic Analysis for Hereditary Thyroid Dysfunction
This advanced test analyzes the thyroid hormone receptor alpha (THRA) gene via Next Generation Sequencing to diagnose congenital non-goitrous hypothyroidism type 6, a rare endocrine disorder. Identifying the pathogenic variant enables precise, lifelong clinical management and familial risk assessment.
| Feature | Our Test (ISO 9001:2015) | Closest Alternative |
|---|---|---|
| Diagnostic Precision | Full Gene Sequencing (NGS) | Targeted SNP Genotyping |
| Methodology | NGS with Copy Number Variation (CNV) Analysis | Sanger Sequencing (Exonic Regions Only) |
| Turnaround Time | 3 to 4 Weeks (Comprehensive Report) | 6 to 8 Weeks |
Physician Insight & Critical Safety Protocol
"Under the DHA license 61713011, I, Dr. Prabhakar Reddy, emphasize that this THRA gene test is a profound tool for diagnostic clarity but must be interpreted within the full phenotypic context; a negative result does not exclude other congenital hypothyroidism etiologies, and a positive result mandates immediate endocrinological correlation to prevent developmental delays. We prioritize genetic counseling to empower families with actionable clinical data."
— Dr. Prabhakar Reddy, Clinical Consultant
⚠️ Medication Safety Warning: Do Not Discontinue Prescribed Medication
Under no circumstances should you alter or stop thyroid hormone replacement therapy or any other prescribed medication based on this test result without explicit consultation with your managing physician.
Exclusion Criteria & Emergency Red Flags
- Neonates undergoing active phototherapy for hyperbilirubinemia require a specialized blood draw protocol; reschedule if acute hemolysis is present.
- Patients who have received a heterologous blood transfusion within 120 days are excluded from DNA extraction from whole blood; use buccal swab or FTA card alternative.
- Emergency Red Flag: If the patient (especially an infant) exhibits severe lethargy, respiratory distress, or unresponsiveness, seek immediate emergency medical services rather than prioritizing this genetic test.
Patient Frequently Asked Questions & Clinical Guidance
What is the clinical utility of the THRA gene for congenital hypothyroidism?
The clinical utility lies in confirming a molecular diagnosis for congenital non-goitrous hypothyroidism type 6, which differentiates it from other thyroid dysgenesis forms, guides the precise titration of levothyroxine therapy, and enables accurate genetic counseling regarding the autosomal dominant inheritance and recurrence risk for future pregnancies.
ما هي متطلبات العينة لإجراء هذا الفحص الجيني المتقدم لجين THRA؟
يُقبل الفحص عينة دم وريدي قياسية بحجم 3 مل في أنبوب EDTA، أو بطاقة FTA تحتوي على قطرة دم واحدة، أو عينة DNA مستخلصة نقية؛ ويشترط وجود تاريخ سريري كامل وجلسة استشارة وراثية مسبقة لرسم شجرة العائلة وتفسير النتيجة بدقة عالية.
How do I prepare for the home collection service and what legal protections apply?
Our pediatric-trained phlebotomists execute a hospital-grade, cold-chain compliant home visit between 8 AM and 11 PM; clinical preparation mandates a prior genetic counselling session as per Federal Decree-Law No. 41 of 2024, and your genomic data is protected under the rigorous UAE PDPL framework, ensuring non-discrimination and absolute confidentiality.
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All reports reviewed by DHA-Certified physicians