Test Price
170 AED✅ Home Collection Available
Anti-Thyroglobulin Antibody (Anti-Tg) Test in Dubai | Automated CLIA Immunoassay
Executive Summary & Core Metrics
The Anti-Thyroglobulin Antibody (Anti-Tg) test is a quantitative serum immunoassay that measures circulating autoantibodies targeting thyroglobulin, a glycoprotein essential for thyroid hormone synthesis. This test delivers 99.9% diagnostic sensitivity via ISO-accredited chemiluminescent processing and is the primary serological marker for autoimmune thyroid disorders including Hashimoto thyroiditis and Graves disease.
Test Overview & Methodology
Anti-Thyroglobulin antibodies (anti-Tg) are immunoglobulin G autoantibodies directed against thyroglobulin, a 660 kDa homodimeric protein that serves as the precursor for triiodothyronine (T3) and thyroxine (T4). Elevated anti-Tg levels are detected in 60–80% of patients with Hashimoto thyroiditis and in approximately 30% of individuals with Graves disease. This assay employs a fully automated, two-site chemiluminescent immunoassay (CLIA) using paramagnetic microparticles coated with recombinant thyroglobulin antigen, enabling high-throughput quantification with a functional sensitivity below 10 IU/mL.
The methodology is standardized against the International Reference Preparation (IRP) 65/93 of the World Health Organization. Results are expressed in IU/mL, and each run includes multi-level quality controls calibrated to Cobas e601 and similar platforms. The test is indicated for differential diagnosis of autoimmune thyroid disease, monitoring of disease progression, and risk stratification in thyroid cancer follow-up where anti-Tg is used as a tumour marker surrogate in athyreotic patients.
| Feature | DNA Labs UAE Service | Alternative Providers |
|---|---|---|
| Diagnostic Sensitivity | 99.9% (CLIA, ISO-accredited) | ~90–92% (ELISA or RIA methods) |
| Methodology | Chemiluminescent Immunoassay (CLIA) on automated platform | Manual ELISA or radioimmunoassay (RIA) |
| Turnaround Time | Same day (daily processing) | 2–3 working days |
| Logistics | VIP mobile phlebotomy & cold-chain home collection (8 AM – 11 PM) | Clinic-based venipuncture only |
| Clinical Support | Telephonic post-test guidance by a licensed general practitioner | No structured follow-up |
Physician Insight & Safety Protocols
"A positive anti-thyroglobulin antibody result should never be interpreted as a standalone diagnosis. It reflects an autoimmune response that may precede overt thyroid dysfunction by months or years. Clinical correlation with serum TSH, free T4, and thyroid ultrasonography is mandatory. For patients under levothyroxine therapy, serial anti-Tg measurements can help track disease activity and guide dose adjustments, but medication changes must always be directed by the treating physician."
— Dr. Ajay Singh, General Practitioner (DHA Registration ID: 36234132)
Medication Advisory
Do not discontinue or alter prescribed thyroid medications (e.g., levothyroxine, methimazole, or propylthiouracil) or radioactive iodine therapy without consulting your physician. This test is intended for diagnostic and monitoring purposes only and does not replace a comprehensive clinical evaluation by an endocrinologist or general practitioner.
Safety Exclusion Criteria & Emergency Indicators
- Do NOT collect sample if: the patient has active bleeding, severe anaemia, or is unable to provide informed consent. Minors under 18 years require accompaniment and written consent from a parent or legal guardian in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Seek emergency care immediately if: you experience sudden neck swelling, difficulty breathing, severe palpitations, fever with agitation, or any signs suggestive of thyroid storm (hyperpyrexia, tachycardia, altered mental status).
- Biotin interference: advise patients to withhold high-dose biotin supplements (>5 mg/day) for at least 24 hours before venipuncture to avoid false-negative immunoassay results.
Patient FAQ & Clinical Guidance
1. What is the Anti-Thyroglobulin Antibody test used for?
This test detects and quantifies autoantibodies that attack thyroglobulin, a protein synthesised by the thyroid gland. It is primarily used to diagnose autoimmune thyroid disorders—most commonly Hashimoto thyroiditis and Graves disease—and to monitor disease activity in patients with known autoimmune thyroiditis. In thyroid cancer follow-up, it also serves as a tumour marker in patients who have undergone total thyroidectomy.
2. What does a positive anti-Tg result mean clinically?
A positive result indicates the presence of circulating autoantibodies but does not independently confirm active disease. Many individuals with positive anti-Tg maintain normal thyroid function for years. Clinical interpretation by a licensed physician is essential, integrating thyroid function tests (TSH, FT3, FT4) and imaging findings to determine the need for treatment or surveillance.
3. How should I prepare for the blood draw?
No fasting is required. Refrain from taking biotin-containing supplements for 24 hours prior to sample collection. Continue all prescribed thyroid medications unless explicitly instructed otherwise by your doctor. The procedure takes less than five minutes and is performed by a licensed phlebotomist using sterile, single-use equipment.
4. When will I receive my results, and how are they delivered?
Results are reported on the same day of sample collection (daily processing). A secure digital report is sent via email or WhatsApp, and a telephonic consultation with a licensed general practitioner is scheduled to discuss the clinical implications. A physical copy is also available at the laboratory counter upon request.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE complies with all applicable federal health data protection and medical liability regulations in the United Arab Emirates. Patient data security and confidentiality are governed by Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing, consent procedures, and safety protocols are conducted in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory operates under DHA Facility License No. 1143 and is ISO 9001:2015 certified (Cert. INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | Anti-Thyroglobulin Antibody (Anti-Tg), Serum |
| Price (AED) | 170 AED |
| Turnaround Time | Same day (daily processing) |
| Sample Type / Matrix | Serum (venous blood); VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM – 11 PM |
| Methodology Used | Chemiluminescent Immunoassay (CLIA) on automated platform |
| ICD-10-CM Code | E06.3 (Autoimmune thyroiditis), E05.00 (Thyrotoxicosis with diffuse goiter), E06.5 (Chronic thyroiditis) |
| LOINC Code | 8099-6 (Thyroglobulin antibody [Units/volume] in Serum) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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