Test Price
1,800 AED✅ Home Collection Available
Clozapine Therapeutic Drug Monitoring (TDM) Test in UAE | 1800 AED | LC-MS/MS
Executive Summary & Core Metrics
This Clozapine TDM service provides quantitative serum analysis of clozapine and its active metabolite norclozapine using ISO-accredited LC-MS/MS methodology. The test supports therapeutic dose optimization and toxicity prevention for patients with treatment-resistant schizophrenia.
- Accuracy Guarantee: 99.9% Analytical Specificity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM to 11 PM).
- Clinical Guidance: Telephonic post-result clinical guidance by DHA-licensed medical professionals.
- Insurance Verification: Direct billing confirmation via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
Clozapine Therapeutic Drug Monitoring (TDM) precisely quantifies serum concentrations of clozapine and its active metabolite norclozapine. This quantitative assay is essential for confirming therapeutic levels (350–600 ng/mL), adjusting dosing in patients with variable metabolism, and preventing dose-related toxicity. The test utilizes Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) to deliver superior specificity compared to standard immunoassay techniques.
| Feature | Our Test (Gold Standard) | Closest Alternative |
|---|---|---|
| Methodology | LC-MS/MS (Liquid Chromatography‑Tandem Mass Spectrometry) | Immunoassay |
| Analytical Specificity | Direct molecular measurement, zero cross-reactivity | Potential interference from metabolites or co-administered drugs |
| Sensitivity/Accuracy | ≥99.9% diagnostic sensitivity | Variable precision; higher rate of false positives |
| Result Turnaround | Report within 2–3 weeks (sample receipt by the 7th of the month) | 1–2 weeks (dependent on send-out reference labs) |
Physician Insight & Safety Protocols
Dr. Ajay Singh (General Practitioner, DHA Registration ID: 36234132) provides this clinical perspective: "Clozapine remains the gold standard for treatment-resistant schizophrenia, but its narrow therapeutic index requires meticulous serum monitoring. The LC-MS/MS assay offers the specificity needed to distinguish the parent drug from its metabolite, enabling precise dose adjustments and minimizing the risk of toxicity. Always interpret serum levels within the context of the full clinical picture before making any therapeutic changes."
Medication Advisory
Do not discontinue or alter your prescribed clozapine dosage without direct consultation with your treating psychiatrist. Abrupt cessation can lead to severe symptom relapse or withdrawal cholinergic rebound.
Safety Exclusion Criteria & Emergency Red Flags
- Absolute Contraindication: Absolute neutrophil count (ANC) below 1500/µL or documented history of clozapine-induced agranulocytosis.
- Relative Exclusion: Concurrent use of myelosuppressive chemotherapeutic agents or severe hepatic impairment (Child-Pugh Class C).
- Seek Immediate Emergency Care if you experience: Fever exceeding 38.3°C, new-onset sore throat, oral ulcers, unusual bruising or bleeding, or extreme fatigue while undergoing clozapine therapy.
Patient FAQ & Clinical Guidance
1. What does the Clozapine TDM test measure?
The test quantitatively measures serum clozapine and norclozapine levels to confirm the therapeutic range and prevent toxicity. This highly specific LC-MS/MS assay helps psychiatrists adjust dosing accurately, particularly in patients who are poor metabolizers, smokers, or those on interacting medications. The standard reference therapeutic range for clozapine is 350–600 ng/mL.
2. When is the correct time to collect the blood sample?
Blood must be drawn as a trough sample, precisely 0.5 to 1 hour before the next scheduled oral dose at steady state. This timing reflects the minimum effective concentration. We require 2 mL of serum collected in a plain Red Top tube (no SST gel barrier tubes). The sample must be immediately refrigerated or frozen to preserve analyte stability.
3. How long does it take to receive the Clozapine TDM report?
Results are reported within 2–3 weeks following sample receipt, provided the specimen arrives by the 7th of the month. This send-out LC-MS/MS protocol guarantees international reference laboratory accuracy. A telephonic clinical guidance consultation is provided upon result release to help interpret the findings and adjust the treatment plan accordingly.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Clinical Compliance
This diagnostic service fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical safety protocols and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Laboratory operations are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and strictly governed under the DHA Facility License Number: 1143.
Clinical & Logistical Metadata
| Test Name | Clozapine Therapeutic Drug Monitoring (TDM) |
| Price (AED) | 1,800 AED |
| Turnaround Time | 2–3 weeks (sample must arrive by the 7th of the month) |
| Sample Type / Matrix | Serum (Standard Peripheral Blood) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM – 11 PM) |
| Methodology Used | LC-MS/MS (Liquid Chromatography‑Tandem Mass Spectrometry) |
| ICD-10-CM Code | Z51.81 (Encounter for therapeutic drug monitoring) |
| LOINC Code | 3585-4 (Clozapine [Mass/volume] in Serum or Plasma) |
| DHA Facility License & Laboratory Address | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA License: 1143 |
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All reports reviewed by DHA-Certified physicians