Test Price
850 AED✅ Home Collection Available
Immunophenotyping by Flow Cytometry: Double Negative T Cells (DNT) Test in UAE | 850 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This state-of-the-art flow cytometry assay quantifies double negative T cells (CD3+ TCRαβ+ CD4- CD8-), a pivotal biomarker for autoimmune lymphoproliferative syndrome (ALPS) and other autoimmune disorders. The test employs a validated multi-parameter panel with TCRαβ gating, achieving a limit of detection below 0.1% and a coefficient of variation under 5%. Results are delivered the next working day when the sample is received by 9 AM, enabling rapid clinical decision-making.
| Feature | Our DNT Test | Closest Alternative |
|---|---|---|
| Precision | Quantitative DNT % with validated 6‑color panel, LOD <0.1%, CV<5% | Qualitative only, not DNT‑specific, poor resolution |
| Method | Multiparameter Flow Cytometry with TCRαβ gating (ISO 15189) | Basic CD4/CD8 T-cell panel, no DNT discrimination |
| Speed | Next working day report (sample received by 9 AM) | Typically 2‑3 business days |
Physician Insight & Safety Protocols
“As a Specialist Diagnostic Radiology professional, I routinely evaluate imaging and laboratory data to support accurate diagnoses. The quantitative DNT result from this flow cytometry assay is a highly specific marker for autoimmune lymphoproliferative syndrome (ALPS). However, the final interpretation must be integrated with the full clinical picture, including history, physical findings, and additional immunological studies. Patients and caregivers are advised not to alter any treatment regimen without direct consultation with their treating physician.”
Medication Advisory
Important Medication Advisory
Do not discontinue any prescribed immunosuppressive therapy, corticosteroids, or other medications without first consulting your treating physician. Abrupt cessation can lead to severe disease rebound or withdrawal complications.
Exclusion Criteria & Emergency Red Flags
- Do not collect if: Recent blood transfusion (<2 weeks), active severe infection, or known congenital immunodeficiency that may confound DNT interpretation.
- Seek immediate medical attention if your child develops: High-grade fever (>38.5°C), rapidly enlarging lymph nodes, unexplained bruising/bleeding, severe pallor, or acute abdominal distension – these may indicate progression of ALPS or a haematological emergency.
Patient FAQ & Clinical Guidance
1. What are double negative T cells and why are they tested?
Answer: Double negative T cells (DNT) are CD3+TCRαβ+ CD4-CD8- lymphocytes that are typically rare in healthy individuals. Elevated levels indicate defective lymphocyte apoptosis, the hallmark of autoimmune lymphoproliferative syndrome (ALPS). Our laboratory uses a validated multi-parameter flow cytometry panel to deliver precise DNT percentages, essential for diagnosis and monitoring of immune dysregulation disorders.
2. Why is this test ordered for my child?
Answer: This test screens for ALPS in children presenting with chronic lymphadenopathy, splenomegaly, and autoimmune cytopenias. It is a frontline investigation when clinical signs suggest a disorder of immune regulation. A definitive result can guide genetic testing (e.g., FAS gene mutations) and timely therapeutic interventions such as sirolimus or mycophenolate mofetil.
3. How is the DNT performed and what is the sample requirement?
Answer: Venipuncture collects two blood tubes (EDTA and heparin) shipped at 18–22°C and analyzed within 24 hours. The sample must never be refrigerated or frozen. Our DHA-licensed phlebotomist arrives at your home between 8 AM and 11 PM; temperature-controlled cold-chain logistics guarantee viability until processing.
UAE Regulatory & Data Privacy Adherence
This diagnostic service strictly adheres to the UAE legal framework for patient data protection and healthcare information security. All personal health information is processed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent requirements follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Laboratory operations are ISO 15189 accredited, ensuring the highest standards of quality and confidentiality.
Clinical & Logistical Metadata
| Test Name | Immunophenotyping by Flow Cytometry: Double Negative T Cells (DNT) |
| Price (AED) | 850 AED |
| Turnaround Time | Next working day (sample received by 9 AM) |
| Sample Type / Matrix | Peripheral whole blood (EDTA and heparin tubes) |
| Methodology Used | Multiparameter Flow Cytometry with TCRαβ gating (ISO 15189) |
| ICD-10-CM Code | D89.82 |
| LOINC Code | 14105-5 |
| DHA Facility License & Laboratory Address | DHA License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians