Test Price
2,800 AEDโ Home Collection Available
HEXB Gene Sandhoff Disease Genetic Test (NGS) in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
This molecular diagnostic assay utilizes Next Generation Sequencing to detect pathogenic variants in the HEXB gene associated with Sandhoff disease. The test delivers 99.9% diagnostic sensitivity through ISO-accredited processing and includes telephonic post-test clinical guidance for result interpretation.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The HEXB gene NGS test screens for pathogenic variants causing Sandhoff disease, a rare lysosomal storage disorder, using state-of-the-art sequencing technology. The assay provides definitive molecular diagnosis for patients and families, enabling accurate genetic counseling and informed family planning decisions.
Performed under strict Dubai Health Authority (DHA) quality standards in an ISO-certified UAE laboratory, this test examines the entire HEXB coding region and splice sites with deep coverage, ensuring detection of single nucleotide variants, small insertions/deletions, and known pathogenic mutations.
| Feature | Our Test (NGS) | Closest Alternative (Enzymatic Assay) |
|---|---|---|
| Precision | 99.9% sensitivity, full gene coverage | Variable, limited to enzyme activity, may miss carriers |
| Method | Next Generation Sequencing (Illumina / LoC-MS/MS verified) | Fluorometric / colorimetric assay |
| Speed | 3โ4 Weeks | 1โ2 Weeks (but lower genetic resolution) |
Physician Insight & Safety Protocols
As a Consultant Medical Genetics specialist, I understand the profound anxiety a suspected genetic diagnosis brings. This test, using Next Generation Sequencing, examines the entire HEXB gene with 99.9% sensitivity, but a positive result must be correlated with clinical symptoms and family history. Please remember, results provide a piece of the puzzle; they are not a standalone verdict.
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory โ Medication Safety
Do not discontinue any prescribed medication without consulting your doctor. Genetic test results do not replace ongoing clinical management. Always discuss findings with your treating physician before making any changes to your treatment plan.
Exclusion Criteria & Emergency Red Flags
- Test not available for minors without legal guardian consent in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Pre-test genetic counseling and signed informed consent are mandatory.
- Not recommended for asymptomatic individuals without clinical suspicion or confirmed family history of Sandhoff disease.
- Emergency Red Flags: Sudden neurological deterioration, new-onset seizures, acute loss of motor skills, or respiratory compromise require immediate medical attention โ do not wait for genetic test results.
Patient FAQ & Clinical Guidance
1. What is the HEXB NGS test and why is it recommended in UAE?
This advanced DNA test sequences the entire HEXB gene to detect pathogenic variants causing Sandhoff disease with 99.9% diagnostic sensitivity under DHA quality standards.
By leveraging Next Generation Sequencing technology in an ISO-certified UAE laboratory, it provides definitive molecular confirmation for patients with suspected Sandhoff disease, enabling accurate genetic counseling and family planning decisions tailored to the regionโs healthcare regulations.
2. How long do results take and how are they delivered?
Results are available in 3 to 4 weeks through our secure patient portal and accompanied by a telephonic clinical guidance session.
The report includes comprehensive variant interpretation using ACMG guidelines. You will receive an email notification as soon as results are validated by our clinical genomics team, with the option of a private consultation to discuss implications.
3. Is home collection available and covered by insurance?
Yes, our ISO-certified cold-chain home collection service is available from 8 AM to 11 PM, and direct billing to UAE insurers can be verified via WhatsApp.
A trained phlebotomist will visit your location equipped with temperature-controlled transport kits; simply schedule via our support line. We assist in checking coverage eligibility with all major UAE payers, including DHA network-approved plans.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed exclusively within UAE jurisdiction. Patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring that every specimen collection and genetic analysis is performed with full informed consent and legal accountability. Our DHA-licensed facility (License No. 1143) maintains ISO-certified quality management systems for laboratory diagnostics.
Clinical & Logistical Metadata
| Test Name | HEXB Gene Sandhoff Disease Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3โ5 mL) or Extracted DNA โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available Daily from 8 AM to 11 PM |
| Methodology Used | Next Generation Sequencing (NGS) โ Illumina Platform with Bioinformatics Analysis |
| ICD-10-CM Code | E75.01 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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ISMS 27001:2022
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HIPAA
All reports reviewed by DHA-Certified physicians