Test Price
2,800 AED✅ Home Collection Available
GPI Gene Genetic Test in UAE | Glucose Phosphate Isomerase Deficiency Diagnosis
Executive Summary & Core Metrics
Comprehensive molecular diagnosis of GPI gene variants causing chronic non‑spherocytic hemolytic anemia. This next‑generation sequencing assay delivers definitive genetic insight for precision clinical management.
- Diagnostic Accuracy: >99.9% mutation‑level sensitivity via ISO‑15189 accredited sequencing pipeline.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily 8 AM – 11 PM.
- Clinical Guidance: Post‑test telephonic result interpretation by DHA‑licensed Consultant Medical Genetics.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The GPI Gene Genetic Test employs massively parallel sequencing (NGS) to analyze the entire coding region and splice‑site junctions of the GPI gene. This approach identifies pathogenic and likely pathogenic variants responsible for glucose phosphate isomerase deficiency, a rare autosomal recessive disorder presenting as chronic non‑spherocytic hemolytic anemia. The assay replaces traditional enzyme activity measurements with definitive molecular evidence, enabling accurate carrier detection, prenatal counselling, and prognostic stratification.
| Feature | Our Test (NGS) | Traditional Enzyme Assay |
|---|---|---|
| Detection Method | Massively Parallel Sequencing (NGS) | Biochemical enzyme activity measurement |
| Diagnostic Sensitivity | >99.9% (mutation‑level) | ~85% (affected by reticulocyte count) |
| Turnaround Time | 3–4 Weeks | 1–2 Days |
| Clinical Utility | Definitive genetic diagnosis, carrier & prenatal testing | Limited to functional confirmation, lacks genetic insight |
Physician Insight & Safety Protocols
“Genetic variants in GPI exhibit variable penetrance; comprehensive clinical evaluation remains essential. This NGS‑based test provides the molecular foundation for accurate counselling and family screening. It does not substitute for ongoing specialist hematology care. Always correlate results with clinical findings and discuss management options with your treating physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory & Pre‑Test Precautions
⚠ Clinical Advisory
Do not discontinue prescribed medication without consulting your doctor. Hemolytic anemia treatments must be managed medically; genetic test results inform but do not replace acute care decisions. Patients with active severe hemolytic crisis requiring urgent transfusion should defer elective genetic testing until clinical stability is achieved.
Exclusion Criteria – When NOT to Use This Test
- Active Severe Hemolytic Crisis: Patients requiring urgent transfusion or intensive monitoring should defer elective genetic testing.
- Minors – Guardian Consent: Written consent from a legal guardian is mandatory per Federal Decree‑Law No. 4 of 2016 on Medical Liability; the test cannot proceed without it.
- Recent Transfusion: If using whole blood or DNA extracted after transfusion, wait at least 4 weeks to avoid donor DNA interference.
- Emergency Red Flags: Sudden drop in hemoglobin, confusion, chest pain, or jaundice with fever — seek emergency care immediately.
Patient FAQ & Clinical Guidance
1. What is the GPI gene test and why is it important?
Snippet: The GPI gene NGS test identifies inherited DNA mutations causing glucose phosphate isomerase deficiency, providing a definitive molecular diagnosis for non‑spherocytic hemolytic anemia.
It replaces older enzyme assays with direct genetic insight, enabling precise prognosis, carrier detection, and prenatal planning. This test is essential for families with unexplained chronic hemolysis.
2. How is the test performed and what sample is needed?
Snippet: Our DHA‑licensed phlebotomist collects a simple blood sample or FTA card spot at your home, and next‑generation sequencing is used to analyze the entire GPI gene.
Acceptable samples include whole blood, extracted DNA, or a dried blood spot on an FTA card. The cold‑chain logistics ensure sample stability from collection to our ISO‑certified lab.
3. What is the turnaround time and total cost?
Snippet: Results are delivered within 3 to 4 weeks at a fixed price of 2,800 AED, which includes pre‑test genetic counseling, sequencing, interpretation, and a post‑test teleconsultation.
No hidden fees apply; the package covers everything from home collection to the final clinical report. Insurance pre‑approval can be verified via WhatsApp before booking.
4. What do my results mean and how are they delivered?
Snippet: Your report classifies variants as pathogenic, likely pathogenic, or benign following ACMG/AMP guidelines and is reviewed by a Consultant Medical Genetics.
A secure digital PDF report is provided via email or patient portal, accompanied by a scheduled telephonic consultation to explain findings and address your questions.
UAE Regulatory & Data Privacy Adherence
This clinical service operates in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Genetic data is encrypted, access‑controlled, and processed under strict confidentiality agreements. All diagnostic procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent protocols are observed at every stage.
Your genetic information is used solely for diagnostic interpretation and is never shared with third parties without explicit written consent. DNA Labs UAE maintains ISO‑15189 accreditation for molecular genetic testing, guaranteeing international standards of quality and accuracy.
Clinical & Logistical Metadata
| Test Name | GPI Gene Genetic Test (Glucose Phosphate Isomerase Deficiency) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card Spot |
| Methodology Used | Next‑Generation Sequencing (NGS) – Massively Parallel Sequencing |
| ICD-10-CM Code | D55.2 |
| LOINC Code | 55369-3 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians