LMNA Gene Sequencing (Hutchinson-Gilford Progeria Syndrome) – Diagnostic Genetic Test in UAE

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation with a DHA-certified genetic counsellor.
Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.

Test Overview & Methodology

The LMNA NGS test provides comprehensive sequencing of the LMNA gene to detect pathogenic variants associated with Hutchinson-Gilford progeria syndrome (HGPS), enabling precise diagnosis, family screening, and proactive paediatric management.

Feature	DNA Labs UAE – NGS Full LMNA	Closest Alternative (Sanger Hotspot)
Coverage	All exons, flanking splice sites + CNV detection	Only exon 11 (c.1824C>T hotspot)
Method	Next-Generation Sequencing (NGS) with MLPA backup	Sanger sequencing
Turnaround Time	21 – 28 Days	14 – 21 Days
Diagnostic Sensitivity	>99% (full gene analysis)	~90% (misses non-classic mutations)
Certification	ISO 9001:2015 / DHA Licensed Facility (1143)	Often not accredited for NGS

Physician Insight & Safety Protocols

“Confirming a diagnosis of Hutchinson-Gilford progeria syndrome is a life-changing moment for any family. Comprehensive LMNA sequencing offers definitive molecular answers, but it is my strong belief that genomic data must always be interpreted within the full clinical context. Our expert team ensures every result is paired with compassionate genetic counselling and a clear roadmap for care.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403

Genetic Test Advisory

The results of this test provide molecular information that should be used in conjunction with a full clinical evaluation by a specialist. Do not make medical decisions based solely on genetic results. A formal consultation with a DHA-licensed genetic counsellor is strongly recommended following the receipt of results.

Exclusion Criteria & Emergency Red Flags

Patient must not be in an acute critical care episode (e.g., severe respiratory distress, uncontrolled seizures) that would compromise sample collection.
Minor patients require written informed consent from both parents or legal guardian, as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Active systemic infection or haemodynamic instability – postpone sample collection until stabilisation.
Emergency Red Flag: If the child presents with acute chest pain, sudden visual loss, or stroke-like symptoms, seek emergency care immediately. This genetic test is not a substitute for urgent medical intervention.
This test is not intended for asymptomatic adult screening without prior genetic counselling and documented family history.

Patient FAQ & Clinical Guidance

1. What does the LMNA NGS test detect?

This test detects pathogenic DNA variants in the entire LMNA gene that cause Hutchinson-Gilford progeria syndrome, enabling early diagnosis and tailored multidisciplinary care planning.

2. What is the turnaround time for results?

Results are delivered within 21 to 28 days. A positive finding indicates a confirmed molecular basis for progeria, which helps guide cardiology, orthopaedic, and nutritional interventions.

3. Is a standard blood sample sufficient for this test?

Yes, the laboratory can process DNA extracted from a standard peripheral whole blood sample. Buccal swabs are also accepted for paediatric patients, making sample collection safe and minimally invasive for newborns and infants.

UAE Regulatory & Data Privacy Adherence

DNA Labs UAE strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing and patient consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Genetic data is handled with the highest security standards under our ISO 9001:2015 certification and DHA Facility License 1143. Home collection is performed by licensed phlebotomists following strict cold-chain protocols.

Clinical & Logistical Metadata

Test Name	LMNA Gene Sequencing (Hutchinson-Gilford Progeria Syndrome)
Price (AED)	2,800
Turnaround Time	21 – 28 Days
Sample Type / Matrix	Peripheral Whole Blood or Buccal Swab
Methodology Used	Next-Generation Sequencing (NGS)
ICD-10-CM Code	E34.8
LOINC Code	83589-1
DHA Facility License & Laboratory Address	Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE \| License No: 1143

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