Test Price
2,800 AED✅ Home Collection Available
ALAD Gene Acute Hepatic Porphyria Genetic Test in UAE | 2800 AED | Next-Generation Sequencing
Executive Summary & Core Metrics
Diagnostic Precision, UAE Regulatory Alignment, and Patient-Centered Logistics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy and Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance from DHA-registered clinicians.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ALAD Gene Acute Hepatic Porphyria Genetic Test uses Next-Generation Sequencing to detect single nucleotide variants, indels, and copy number variations in the ALAD gene, confirming delta-aminolevulinic acid dehydratase deficiency porphyria. This advanced molecular analysis empowers gastroenterologists, geneticists, and clinical researchers to establish a definitive genetic diagnosis, guide family screening, and tailor management strategies for acute hepatic porphyria.
Test Comparison: NGS Solution versus Conventional Screening
| Feature | Our Test (ALAD NGS) | Standard Porphyria Panel |
|---|---|---|
| Diagnostic Sensitivity | ≥99.9% | 85–92% (biochemical only) |
| Methodology | Next-Generation Sequencing (NGS) | Enzymatic assay / Porphyrin profile |
| Turnaround Time | 3–4 Weeks | Variable (often 2–6 weeks) |
| Clinical Utility | Gene-level risk, carrier detection, family planning | Acute attack confirmation only |
Physician Insight & Safety Protocols
As a Consultant Medical Genetics specialist, I emphasize that this NGS test accurately identifies pathogenic variants in the ALAD gene associated with acute hepatic porphyria. However, genetic findings must be correlated with biochemical markers, symptom history, and a comprehensive family pedigree. Patients should never discontinue prescribed treatments without consulting their supervising physician. Our telephonic post-test session is designed to help you interpret your results within the full context of your personal and family health profile.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
Important Clinical Caution
Do not stop or alter any prescribed medication without explicit guidance from your treating physician. Genetic test results provide diagnostic and risk information but do not replace ongoing clinical management or emergency care.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients experiencing an active acute hepatic porphyria crisis characterized by severe abdominal pain or neuropsychiatric symptoms require urgent medical stabilization prior to any elective genetic testing.
- Exclusion: Minors under 18 years of age without written consent from a legal guardian, in accordance with UAE personal data protection regulations.
- Exclusion: Individuals currently receiving unfractionated heparin therapy that contraindicates venipuncture; alternative collection arrangements must be discussed with the referring physician.
- Red Flag – Seek Immediate Care: If you develop intense abdominal pain, confusion, seizures, or dark urine during the testing process, these signs may indicate an acute porphyric attack. Proceed to the nearest Emergency Department without delay.
Patient FAQ & Clinical Guidance
1. What is the ALAD Gene Acute Hepatic Porphyria Genetic Test?
This molecular diagnostic test uses Next-Generation Sequencing to detect pathogenic variants in the ALAD gene that cause delta-aminolevulinic acid dehydratase deficiency porphyria, a rare form of acute hepatic porphyria. The analysis identifies single nucleotide variants, small insertions and deletions, and copy number alterations with high sensitivity, enabling accurate diagnosis, carrier detection, and informed family planning.
2. How is the test performed and what sample is required?
A standard peripheral whole blood sample is collected via VIP mobile phlebotomy at your home or preferred location. No fasting or special preparation is necessary. The blood specimen is transported under temperature-controlled cold-chain logistics to our ISO 9001:2015 accredited laboratory, where DNA extraction and NGS sequencing are performed to identify ALAD gene variants with 99.9% sensitivity.
3. How soon will I receive the results and what support is provided afterward?
Results are reported within 3–4 weeks from sample receipt. A comprehensive post-test genetic counseling session is included, conducted by a DHA-licensed Consultant Medical Genetics specialist. This session interprets your results, discusses implications for at-risk family members, recommends confirmatory biochemical testing if indicated, and provides a detailed written medical report for your referring physician.
UAE Regulatory & Data Privacy Adherence
Trust and Compliance Framework
This genetic testing service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent. The laboratory is licensed by the Dubai Health Authority (DHA Facility License No. 1143) and holds ISO 9001:2015 certification for quality management. Patient genetic data is encrypted, access-controlled, and processed solely for diagnostic purposes with explicit consent.
Clinical & Logistical Metadata
| Test Name | ALAD Gene Acute Hepatic Porphyria Genetic Test (Next-Generation Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene coding regions and splice sites |
| ICD-10-CM Code | E80.29 (ALA dehydratase deficiency porphyria), Z15.09 (Genetic susceptibility), Z84.81 (Family history of genetic disease carrier) |
| LOINC Code | 99124-6 (ALAD gene full mutation analysis) |
| DHA Facility License & Address | DHA Facility License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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