Paroxysmal Nocturnal Hemoglobinuria (PNH) Confirmatory Test in UAE | 1500 AED | DHA Licensed

Executive Summary & Core Metrics

Executive Summary

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
Clinical Guidance: Telephonic post-test clinical correlation and result interpretation by DHA-licensed Specialist Diagnostic Radiologists.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

The Paroxysmal Nocturnal Hemoglobinuria (PNH) Confirmatory Test is the definitive diagnostic assay for detecting PNH clones via high-sensitivity FLAER-based flow cytometry. It precisely quantifies glycosylphosphatidylinositol (GPI)-anchored protein deficiency on erythrocytes and leukocytes, enabling early diagnosis and monitoring of this rare, life-threatening hematologic disorder.

Clinical Applications & Specialist Referral

This test is indicated in patients with unexplained hemolytic anemia, recurrent thrombosis, bone marrow failure, or a positive screening test. It is ordered primarily by Consultant Hematologists for definitive diagnosis and monitoring of complement inhibitor therapy, by Hematopathologists for technical validation of flow cytometry findings, and by Preventive Medicine physicians screening for unexplained anemia or thrombosis in high-risk patients.

Feature	Our Test (PNH Confirmatory – FLAER)	Closest Alternative (Standard CD55/CD59 Screen)
Methodology	FLAER + Multicolor Flow Cytometry (CD55/CD59 on RBCs & WBCs)	CD55/CD59 Flow Cytometry without FLAER
Diagnostic Sensitivity	>99.9% (detects clones as low as 0.01%)	~95% (may miss small clones)
Turnaround Time	Same day (report by 9 PM)	2–3 working days
Clinical Utility	Gold standard for diagnosis, clone size monitoring, and treatment response evaluation	Initial screening only; requires confirmation

Physician Insight & Safety Protocols

“Confirming a PNH diagnosis can be a turning point for both patient and clinician. This FLAER-based assay delivers the precision needed for confident clinical decisions, yet results must always be weighed against the complete clinical picture. Our team is dedicated to supporting you through every stage of the diagnostic journey.”

— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011

Medication Advisory

⚠️ Do not discontinue any prescribed medication, including blood thinners or complement inhibitors, without consulting your treating physician.

Patients currently receiving eculizumab or ravulizumab should inform the laboratory prior to sample collection to ensure accurate interpretation of clone size and lineage involvement.

Exclusion Criteria & Emergency Red Flags

Do not draw blood if any of the following apply:

Blood transfusion within the last 48 hours (may cause false-negative results).
Severe thrombocytopenia (<20,000/µL) requiring urgent platelet transfusion.
Inability to provide informed consent; minors require parental consent in accordance with UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.

Seek immediate emergency care if you experience:

Sudden severe abdominal, chest, or back pain.
Dark cola-colored urine or rapidly worsening anemia.
New swelling, redness, or pain in one limb (possible deep vein thrombosis).
Shortness of breath, confusion, or neurological symptoms (possible pulmonary embolism or stroke).

Patient FAQ & Clinical Guidance

1. What is the PNH Confirmatory Test and why is it ordered?

This test definitively identifies PNH clones by detecting the absence of GPI-anchored proteins on blood cells, confirming a life-threatening hematopoietic stem cell disorder. It is indicated in patients with unexplained hemolytic anemia, recurrent thrombosis, bone marrow failure, or a positive screening test. Early confirmation guides life-saving therapy with complement inhibitors.

2. Why is FLAER-based flow cytometry the gold standard?

FLAER directly binds to the GPI anchor itself, offering superior sensitivity and specificity compared to traditional CD55/CD59 staining, detecting even subclinical PNH clones. Our methodology combines FLAER with multicolor antibodies to analyze both red and white blood cells, allowing precise quantification of clone size and lineage involvement—critical for diagnosis and monitoring.

3. How should I prepare for the PNH Confirmatory Test?

No fasting is required. Inform the phlebotomist of all medications and recent transfusions during the home collection visit. Avoid non-essential supplements that may affect coagulation (e.g., high-dose vitamin E, fish oil) on the day of collection. The sample must be transported at controlled room temperature (18–22°C) and processed immediately to maintain cell viability.

UAE Regulatory & Data Privacy Adherence

Data Protection: All patient data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.

Clinical Safety: Patient consent and clinical safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.

Accreditation: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). DHA Facility License Number: 1143.

Contact: WhatsApp +971 54 548 8731. All clinical correlations require physician review.

Clinical & Logistical Metadata

Test Name	Paroxysmal Nocturnal Hemoglobinuria (PNH) Confirmatory Test
Price (AED)	1500 AED
Turnaround Time	Same day (report by 9 PM)
Sample Type / Matrix	Whole Blood (EDTA & Sodium Heparin tubes) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available Daily from 8 AM to 11 PM
Methodology Used	FLAER + Multicolor Flow Cytometry (CD55/CD59 on RBCs & WBCs)
ICD-10-CM Code	D59.5
LOINC Code	93975-0
DHA Facility License & Laboratory Address	DHA Facility License Number: 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE \| DNA Labs UAE