Test Price

2,800 AED

✅ Home Collection Available

SYNJ1 Gene (PARK20) Parkinson Disease Genetic Test in UAE | 2,800 AED | DHA Licensed

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Post-Test Telephonic Interpretation Session with a Consultant Medical Genetics (DHA-licensed).
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

This advanced SYNJ1 (PARK20) Parkinson Disease Genetic Test uses next-generation sequencing (NGS) to detect pathogenic variants in the SYNJ1 gene, which causes autosomal recessive juvenile-onset parkinsonism. The test is designed for individuals with a family history of early-onset Parkinson disease or atypical parkinsonian features. Our targeted NGS approach delivers comprehensive coverage of all coding exons and flanking intronic regions, followed by Sanger sequencing confirmation for every reported variant.

Feature	Our SYNJ1 NGS Test	Whole Exome Sequencing (Alternative)
Precision	≥99.9% analytical sensitivity for SYNJ1 coding & intronic flank regions	Varies; may miss deep intronic or regulatory variants
Methodology	Targeted NGS with Sanger confirmation of all reported variants	Broad capture of coding exons across all genes
Turnaround Time	3–4 Weeks	6–12 Weeks
Clinical Utility	Direct diagnosis of PARK20-linked parkinsonism; guides prognosis & family planning	May incidentally detect unrelated findings; requires extensive bioinformatic filtering

Physician Insight & Safety Protocols

“As a Consultant Medical Genetics, I emphasize that genetic testing for Parkinson disease must always be accompanied by comprehensive pre-test counseling and a detailed three-generation pedigree analysis. A positive SYNJ1 variant should never be interpreted in isolation—it requires correlation with clinical phenotype, neurological examination, and neuroimaging. I strongly advise patients to discuss results with their referring physician and a certified genetic counselor before making any medical decisions.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)

⚠️ Critical Medication Advisory

Do not discontinue, reduce, or alter any prescribed antiparkinsonian medication—including levodopa, dopamine agonists, or MAO-B inhibitors—based solely on this genetic result. Abrupt withdrawal can precipitate a life-threatening parkinsonian crisis characterized by severe rigidity, hyperpyrexia, and altered consciousness. Always consult your treating neurologist before making any therapy changes.

🚨 Exclusion Criteria & Safety Precautions

Exclusion Criteria (Do Not Proceed)

Age below 18 years (testing of minors requires explicit legal guardian consent and documented clinical justification per Federal Decree-Law No. 4 of 2016 on Medical Liability).
Inability to provide informed consent due to cognitive impairment or unresolved legal guardianship status.
Active severe psychiatric condition that may impair comprehension of genetic results.
Unverified identity—government-issued Emirates ID must match the requisition form exactly.

Emergency Red Flags

New-onset suicidal ideation or acute severe depression occurring after receipt of genetic results.
Sudden worsening of motor function (e.g., inability to walk, severe rigidity, dysphagia)—seek immediate emergency care.
Adverse effects following self-adjustment of antiparkinsonian medications.

Patient FAQ & Clinical Guidance

1. What does the SYNJ1 PARK20 Genetic Test detect?

This test identifies disease-causing mutations in the SYNJ1 gene, which are responsible for autosomal recessive juvenile-onset parkinsonism (PARK20). The analysis covers all coding exons, splice sites, and flanking intronic regions using high-depth next-generation sequencing.

2. How is the sample collected for this test?

A standard peripheral whole blood sample (2–5 mL in an EDTA tube) is collected via our VIP Mobile Phlebotomy service, available daily from 8 AM to 11 PM. The specimen is transported under temperature-controlled cold-chain conditions to our ISO-accredited laboratory.

3. Is genetic counseling necessary before testing?

Yes, pre-test genetic counseling is mandatory for this test. We provide a dedicated session with a qualified genetic counselor to review your personal and family medical history, draw a detailed pedigree, and discuss the scope of results, including the possibility of incidental findings.

4. What is the turnaround time for results?

The standard turnaround time is 3–4 weeks from the date of sample receipt at our laboratory. This includes sequencing, bioinformatic analysis, Sanger confirmation of all reported variants, and clinical interpretation by our genetics consultants.

5. Will my insurance cover this test?

Coverage varies by insurance provider and policy. Our team can verify your direct billing eligibility via WhatsApp at +971 54 548 8731. We recommend contacting your insurer to confirm pre-authorization requirements before scheduling collection.

UAE Regulatory & Data Privacy Adherence

This genetic testing service fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient genetic data is encrypted both in transit and at rest, processed exclusively within UAE-licensed facilities, and retained only for the duration required by applicable health regulations. Your genomic information is never shared with third parties without explicit written consent, as required under PDPL Article 9. Clinical safety and informed consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.

Accreditation: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139). Laboratory methodology follows DHA and MOHAP standard nomenclature for genetic testing.

Clinical & Logistical Metadata

Test Name	SYNJ1 Gene (PARK20) Parkinson Disease Genetic Test
Price (AED)	2,800 AED
Turnaround Time	3–4 Weeks
Sample Type / Matrix	Peripheral Whole Blood (EDTA) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection
Methodology Used	Targeted Next-Generation Sequencing (NGS) of SYNJ1 coding exons and flanking intronic regions with Sanger confirmation of all reported variants
ICD-10-CM Code	G20 (Parkinson's disease)
LOINC Code	82939-0 (Gene mutations found in Blood by Sequencing)
DHA Facility License & Address	License No: 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE

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