Test Price
2,800 AED✅ Home Collection Available
DYSF Gene (Miyoshi Myopathy) Genetic Test in UAE | AED 2,800 | DNA Labs UAE
Executive Summary & Core Metrics
✅ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited NGS Processing
🚚 Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM – 11 PM)
📞 Clinical Guidance: Post-Test Telephonic Result Interpretation by DHA-Licensed Consultant Medical Geneticist
📋 Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
📌 DHA Facility License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Test Overview & Methodology
This comprehensive next-generation sequencing (NGS) test screens the entire DYSF gene for pathogenic variants linked to Miyoshi myopathy and related dysferlinopathies. The assay provides complete exon and intron coverage with high analytical sensitivity, enabling precise molecular diagnosis and informed family planning decisions.
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Precision | 99.9% Sensitivity (Full Gene Coverage) | Targeted Single Variant Only |
| Method | Next‑Generation Sequencing (Illumina®) | Capillary Sanger Sequencing |
| Turnaround Time | 3 – 4 Weeks | 6 – 8 Weeks |
| Sample Required | Peripheral Whole Blood (3–5 mL EDTA) or Extracted DNA | Blood or DNA |
Physician Insight & Safety Protocols
“When a patient presents with progressive distal muscle weakness and elevated creatine kinase, a targeted DYSF gene analysis is indispensable for confirming the diagnosis of Miyoshi myopathy. Identifying the precise mutation not only clarifies prognosis but also guides reproductive choices and informs the risk assessment for asymptomatic siblings. I always counsel families that genetic results must be interpreted alongside clinical examination and electrophysiological studies — a comprehensive approach ensures no alternative treatable myopathy is overlooked.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory Notes for Patients
⚠️ Medication Advisory
Do not discontinue or alter any prescribed medication without first consulting your neurologist or treating physician. Genetic findings may influence therapeutic decisions, but abrupt changes can lead to serious complications.
Exclusion Criteria & Emergency Red Flags
- Not intended for patients with acute life-threatening conditions requiring immediate emergency intervention.
- Home collection is contraindicated if an uncontrolled bleeding disorder is present or if the patient is unable to cooperate.
- Emergency red flags: Sudden severe muscle weakness, difficulty breathing, chest pain, or loss of consciousness — seek immediate emergency care at the nearest hospital.
Patient FAQ & Clinical Guidance
1. What is the DYSF gene and how does it relate to Miyoshi myopathy?
Answer: The DYSF gene provides instructions for producing dysferlin, a protein essential for repairing damaged muscle cell membranes. Mutations in DYSF lead to dysferlin deficiency, causing Miyoshi myopathy — a distal muscular dystrophy that typically begins in early adulthood with weakness in the calf muscles.
2. How is the test performed and what sample is required?
Answer: The test requires a peripheral whole blood sample (3–5 mL in an EDTA tube) collected by our DHA‑licensed mobile phlebotomist. Alternatively, a high-quality extracted DNA sample or a dried blood spot on an FTA card is acceptable. Collection is performed at your home or office between 8 AM and 11 PM daily.
3. What is the turnaround time and is genetic counseling included?
Answer: Results are available within 3 to 4 weeks from sample receipt. A mandatory pre-test genetic counseling session is conducted to obtain informed consent, review family history, and draw a pedigree chart. Post-test counseling is also provided to discuss the clinical implications of the results.
4. Can this test distinguish between Miyoshi myopathy and other muscular dystrophies?
Answer: Yes, comprehensive DYSF sequencing can differentiate Miyoshi myopathy from other genetically distinct myopathies such as limb-girdle muscular dystrophy type 2B and inclusion body myositis. However, clinical correlation with electromyography and muscle biopsy remains important for a complete diagnostic picture.
5. Is the test covered by insurance and how do I verify my coverage?
Answer: Many insurance plans provide partial or full coverage for genetic testing when ordered by a specialist. To verify your coverage, send a photo of your insurance card via WhatsApp to +971 54 548 8731 and our billing team will confirm your benefits within 24 hours.
UAE Regulatory & Data Privacy Adherence
⚕️ This genetic testing service complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent are upheld at every stage.
ISO 9001:2015 Certified | Cert: INT/EGQ/2509DA/3139 | DHA Facility License No. 1143 | DNA Labs UAE – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Clinical & Logistical Metadata
| Test Name | DYSF Gene (Miyoshi Myopathy) Genetic Test – Full Gene Sequencing by NGS |
| Price (AED) | AED 2,800 |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (Illumina®) – Full DYSF Gene Coverage Including Exon-Intron Boundaries |
| ICD-10-CM Code | G71.0 (Muscular Dystrophy) |
| LOINC Code | 94805-5 (DYSF gene mutation analysis in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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