Test Price
2,800 AEDโ Home Collection Available
CAV3 Genetic Testing (Limb-Girdle Muscular Dystrophy Type 1C) in UAE | 2800 AED | DHA Approved Guidelines
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity through ISO 9001:2015 Certified Next-Generation Sequencing (Cert: INT/EGQ/2509DA/3139). Premium Logistics: Paid Hospital-Grade Home Collection (8 AM โ 11 PM) with ISO Certified Cold-Chain Transport & VIP Mobile Phlebotomy. Clinical Guidance: Complimentary Telephonic Post-Test Interpretation by a Genetic Counsellor. Insurance: Instant Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The CAV3 Gene Next-Generation Sequencing (NGS) test definitively diagnoses Limb-Girdle Muscular Dystrophy Type 1C (LGMD1C), an autosomal dominant disorder caused by pathogenic variants in the caveolin-3 gene. This single-gene assay replaces outdated Sanger-only workflows, offering simultaneous detection of single nucleotide variants, small indels, and copy number alterations in a single, highly accurate workflow.
| Benchmark | Our Test (DHA/MOHAP Standard) | Closest Alternative (Sanger Sequencing Only) |
|---|---|---|
| Methodology | NGS (full gene coverage) with CNV analysis + Sanger confirmation of reported variants | Bidirectional Sanger sequencing of coding exons only |
| Detection Rate | >99.9% for pathogenic variants in CAV3 coding and splice regions | ~95%, may miss deep intronic variants and large deletions |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
| Price (UAE) | 2,800 AED | Often >3,500 AED at foreign labs |
Physician Insight & Safety Protocols
โAs a Consultant Medical Genetics, I emphasize that a positive CAV3 test confirms the molecular diagnosis but must be correlated with your clinical symptoms, muscle biopsy findings, and family history. A negative result does not entirely rule out LGMD; a comprehensive neuromuscular gene panel may be warranted if suspicion persists. Always interpret these results with a clinical geneticist.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Medication Advisory
โ ๏ธ Do Not Discontinue Prescribed Therapy
Do not stop any cardiac, respiratory, or corticosteroid regimen without explicit instructions from your treating physician. Sudden cessation may trigger severe complications, especially in LGMD patients with cardiac involvement.
Exclusion Criteria & Emergency Red Flags
Safety Check
- Exclusion criteria for home collection: Active fever, uncontrolled bleeding diathesis, or inability to provide informed consent (requires legal guardian).
- If you experience sudden chest pain, palpitations, difficulty breathing, or progressive muscle weakness leading to falls, go to the nearest emergency department.
- This test is not intended for pre-symptomatic screening of minors without DHA-approved genetic counseling in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the diagnostic accuracy of the CAV3 NGS test for LGMD1C?
Our CAV3 next-generation sequencing delivers 99.9% analytical sensitivity and specificity for detecting known pathogenic variants, ensuring a reliable molecular diagnosis when combined with expert clinical evaluation.
2. What sample types are accepted and how is home collection performed?
We accept a single 4 ml EDTA whole blood tube, extracted DNA (minimum 2 ยตg), or a dried blood spot on an FTA card; a certified phlebotomist arrives at your home within a 2-hour window for a painless, 5-minute procedure. VIP Mobile Phlebotomy is available daily from 8 AM to 11 PM.
3. Is genetic counseling mandatory before ordering this test in the UAE?
Yes, pre-test genetic counseling is mandatory under UAE regulations. Our package includes a 30-minute session to draw a pedigree and explain implications before sample collection, in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance: All genetic testing adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is stored locally in DHA-audited servers with strict access controls. Our laboratory holds DHA Facility License 1143 and ISO 9001:2015 certification (INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | CAV3 Genetic Testing (Limb-Girdle Muscular Dystrophy Type 1C) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral blood (EDTA whole blood), extracted DNA (โฅ2ยตg), or dried blood spot on FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV analysis and Sanger confirmation |
| ICD-10-CM Code | G71.0 (Muscular dystrophy) |
| LOINC Code | 88861-4 (CAV3 gene mutation analysis) |
| DHA Facility License & Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians