Test Price
2,800 AED✅ Home Collection Available
FA2H Gene SPG35 Next-Generation Sequencing (NGS) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل الجين FA2H (SPG35) بتقنية التسلسل الجيني من الجيل التالي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Clinical-Grade Genetic Certainty with UAE‑Powered Patient Support
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital‑Grade Home Collection via ISO‑Certified Cold‑Chain Transport and VIP Mobile Phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Complimentary Telephonic Post‑Test Clinical Guidance by a DHA‑licensed neurogenetic specialist to explain results and next steps.
- Insurance: Direct Billing Verification – send your E‑Card via WhatsApp at +971 54 548 8731.
الفحص الجيني للكشف عن الطفرات المسببة للشلل التشنجي الوراثي من النوع 35 بدقة تشخيصية 99.9% عبر مختبر معتمد ISO 9001:2015. خدمة سحب منزلي طبية محترفة مع استشارة جينية هاتفية بعد الفحص.
Test Overview
The FA2H Gene SPG35 Genetic Test identifies pathogenic variants in the FA2H gene responsible for spastic paraplegia type 35 (SPG35), an autosomal recessive neurodegenerative disorder characterized by progressive lower limb spasticity and weakness, often accompanied by cognitive decline and seizures. This advanced next-generation sequencing test screens the entire coding region with unmatched precision, enabling early diagnosis, tailored management, and informed family planning.
يحدد تحليل تسلسل الجين FA2H من الجيل التالي الطفرات المسببة للشلل التشنجي الوراثي من النوع 35، وهو اضطراب عصبي تنكسي متنحٍّ يتميز بتيبّس وتشنج في الأطراف السفلية مع احتمالية تدهور معرفي ونوبات صرعية.
| Feature | Our FA2H NGS Test (UAE Clinical Lab) | Closest Alternative (Standard Panel) |
|---|---|---|
| Precision | Near 100% analytical sensitivity/specificity for SNVs, small indels & copy number variants – full coding region | ~95% sensitivity; limited to hot‑spot exons, may miss deep intronic or regulatory variants |
| Method | NGS (Next‑Generation Sequencing) with bi‑directional Sanger confirmation for all pathogenic calls | Targeted genotyping or exome‑based capture; often lacks validation for copy number |
| Turnaround | 3 to 4 weeks from sample receipt | 4 to 6 weeks (with outsourcing) |
| Report | Clinically annotated, VUS classification per ACMG 2026, genetic counseling summary | Raw variant list only; interpretation left to ordering physician |
Physician Insight & Safety Protocol
“As a clinical neurologist, I emphasize that a positive FA2H result confirms SPG35 but must be correlated with the patient’s neurological exam and family history. A negative result does not rule out other hereditary spastic paraplegias; targeted multi‑gene panel or exome sequencing may be indicated if clinical suspicion is high. Always involve a genetic counselor to discuss reproductive risks and potential clinical trials.” — Dr. PRABHAKAR REDDY, DHA License 61713011
⚠️ IMPORTANT: Do not discontinue or alter any prescribed medication based solely on this test result. Always consult your treating neurologist.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals with acute febrile illness, recent blood transfusion (<4 weeks), or current use of systemic immunosuppressants that may alter DNA stability should postpone sample collection.
- Minors’ Consent: Genetic testing for asymptomatic minors under UAE CDS Law 2026 requires explicit parental consent and a pre‑test genetic counseling session; the report may be released only to the pediatric neurologist managing the case.
- Red Flags – seek urgent neurological evaluation if you experience: sudden loss of ambulation, acute vision changes, new‑onset uncontrolled seizures, or severe respiratory difficulty.
Frequently Asked Questions
What exactly does the FA2H gene test detect, and why is SPG35 significant?
This test screens the entire FA2H gene for pathogenic variants that cause spastic paraplegia type 35, a progressive neurodegenerative disorder characterised by lower‑limb spasticity, ataxia, and often cognitive decline. The FA2H enzyme is critical for myelin maintenance; biallelic loss‑of‑function mutations disrupt lipid metabolism, leading to central nervous system leukodystrophy. Early molecular confirmation enables precise symptomatic management, avoids unnecessary invasive investigations, and informs family risk for autosomal recessive inheritance.
ماذا يكشف تحليل الجين FA2H بالضبط وما أهمية SPG35؟
يفحص التحليل كامل الجين FA2H بحثاً عن الطفرات المسبّبة للشلل التشنجي الوراثي من النوع 35، وهو اضطراب تنكّسي عصبي يتميز بتيبّس الأطراف السفلية وترنّح مع تدهور معرفي. يؤكّد التشخيص الجيني المبكّر آليات الخلل في الميالين ويوجّه التدبير العلاجي والاستشارة الوراثية للعائلة.
How should I prepare for the test, and what sample types are accepted?
No fasting or special preparation is needed; you can provide one of three sample types: 4 mL whole blood in an EDTA tube, extracted DNA (≥2 µg), or a dried blood spot on an FTA card from a single finger‑prick. A pre‑ genetic counselling session, including a detailed pedigree chart of affected family members, is mandatory to comply with UAE genetic testing regulations and to ensure result interpretation accuracy. Our DHA‑licensed staff will collect the sample at your home and guide you through the consent process.
كيف أستعد للفحص وما أنواع العينات المقبولة؟
لا يحتاج الفحص لصيام أو تحضير خاص؛ تقبل عينة دم وريدي 4 مل أو حمض نووي مستخلص أو بقعة دم جاف على بطاقة FTA. يشترط جلسة استشارة جينية سابقة مع رسم شجرة العائلة. يُجري فريقنا المرخّص من هيئة الصحة السحب المنزلي ويُكمل الموافقة المستنيرة.
What does a 3–4 week turnaround mean for my medical management?
The 3–4 week timeframe from sample arrival ensures thorough NGS sequencing, bi‑directional Sanger confirmation, and expert clinical annotation of every variant according to ACMG 2026 guidelines—critical for avoiding false positives or misclassified VUS. Results are released directly to your referring neurologist via a secure portal; urgent findings are flagged and communicated within 5 working days. Once the diagnosis is confirmed, your physician can expedite physiotherapy, anti‑spastic medications, and, if eligible, enrolment in gene‑specific natural history studies or future clinical trials.
ماذا تعني فترة 3–4 أسابيع بالنسبة لخطتي العلاجية؟
تتيح المدة المذكورة تحليلاً شاملاً للتسلسل مع تأكيد سانغر وتصنيف سريري دقيق وفق إرشادات 2026. تُرسل النتائج للطبيب المعالج عبر بوابة آمنة؛ والحالات العاجلة تُبلَغ خلال 5 أيام عمل. بعد التشخيص المؤكد يمكن البدء في العلاج الطبيعي والأدوية المضادة للتشنج والمشاركة في الدراسات الجينية.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians