Test Price
2,800 AED✅ Home Collection Available
TRPC6 Gene Focal Segmental Glomerulosclerosis Type 2 Genetic Test in UAE | 2800 AED
Executive Summary
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing and NGS with full exon coverage of the TRPC6 gene.
- ✓ Premium Logistics: VIP Mobile Phlebotomy and Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- ✓ Clinical Guidance: Telephonic post-test clinical guidance for result interpretation by DHA-licensed genetics specialists.
- ✓ Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TRPC6 Gene NGS Test comprehensively sequences the entire coding region of the TRPC6 gene to identify pathogenic variants linked to autosomal dominant focal segmental glomerulosclerosis type 2 (FSGS2). This test is essential for confirming a clinical diagnosis, guiding treatment decisions, and enabling family screening. Results must be correlated with renal biopsy findings, family history, and clinical course for accurate interpretation.
| Feature | Our NGS TRPC6 Test | Closest Alternative (Limited Panel) |
|---|---|---|
| Precision | Full gene sequencing (all exons and splice sites) | Only 2–3 known hot-spot mutations |
| Method | Next Generation Sequencing (NGS) with CNV detection | Sanger sequencing of selected amplicons |
| Turnaround | 3–4 Weeks (ISO cold-chain handling) | 2–3 Weeks (may require confirmatory NGS later) |
| Clinical Utility | Aids in renal transplant evaluation, prognosis, and familial risk assessment | Limited screening; high false-negative rate |
Physician Insight & Safety Protocols
“As a clinical geneticist, I emphasize that a TRPC6 variant result must be interpreted within the full clinical context including renal histopathology, family pedigree, and laboratory parameters. A positive result confirms the diagnosis but does not replace ongoing nephrology care. This test empowers families with clarity for surveillance and early intervention.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed immunosuppressive, antihypertensive, or renoprotective therapy based solely on genetic test results without consulting your nephrologist. Genetic information complements but does not replace clinical judgment.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Minors must have documented parental or guardian consent in compliance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields; pre-test genetic counselling is mandatory for all minors.
- Exclusion: Patients unable to provide a valid clinical history and pedigree chart covering at least three generations will be rescheduled for mandatory pre-test counselling before sample collection.
- Red Flag: If you experience sudden flank pain, rapid lower extremity edema, or oliguria while awaiting results, proceed immediately to the nearest emergency department.
- Red Flag: A negative genetic result does not rule out other forms of FSGS or primary renal disease; ongoing nephrology follow-up is essential.
Patient FAQ & Clinical Guidance
1. What exactly does the TRPC6 NGS test detect?
This test sequences all coding exons and splice junctions of the TRPC6 gene to identify pathogenic or likely pathogenic variants that cause autosomal dominant focal segmental glomerulosclerosis type 2 (FSGS2). It enables a precise molecular diagnosis and allows at-risk family members to undergo targeted screening.
2. How is the sample collected and what are the options?
Our VIP Mobile Phlebotomy service sends a certified phlebotomist to your home for a simple blood draw (3–5 mL in an EDTA tube), or you may provide a dried blood spot on an FTA card. All samples are transported under strict temperature-controlled cold-chain protocols to ensure DNA integrity.
3. Why does the test take 3–4 weeks and can I get faster results?
The standard turnaround time of 3–4 weeks ensures rigorous bioinformatic analysis, orthogonal confirmation of all detected variants, and independent clinical review by two genetics specialists. Expedited reporting within 2 weeks is available for urgent clinical scenarios at an additional fee.
4. Will insurance cover the cost of this genetic test?
Coverage varies by insurance provider and policy. Our team can perform a direct billing verification via WhatsApp at +971 54 548 8731 to confirm your eligibility and any applicable co-pay or deductible.
5. What happens after I receive my positive or negative result?
You will receive a telephonic post-test clinical guidance session with a DHA-licensed genetics specialist. For positive results, a detailed family screening plan and nephrology referral pathway will be discussed. Negative results do not exclude all genetic forms of FSGS and continued clinical monitoring is recommended.
UAE Regulatory & Data Privacy Adherence
This genetic testing service operates in full compliance with UAE federal laws governing health data and personal privacy:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — all genetic sequence data is encrypted and stored within UAE-based servers.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — governs the handling of electronic health records and telemedicine guidance.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — ensures patient consent, clinical safety, and accountability in diagnostic procedures.
All laboratory processes are ISO 9001:2015 certified. Your genetic information is never shared with third parties without your explicit written consent.
Clinical & Logistical Metadata
| Test Name | TRPC6 Gene Focal Segmental Glomerulosclerosis Type 2 (FSGS2) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (expedited 2-week option available) |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) or Dried Blood Spot on FTA card |
| Methodology Used | Next Generation Sequencing (NGS) with full exon coverage and CNV detection |
| ICD-10-CM Code | N04.1, Z13.7 |
| LOINC Code | 87851-7 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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