Test Price
2,800 AED✅ Home Collection Available
CLCN5 Gene Nephrolithiasis Type 1 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CLCN5 لتكلس الكلية النوع الأول بتقنية التسلسل الجيني من الجيل التالي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary: Ultra‑precise NGS testing for CLCN5 mutations causing Dent disease/Nephrolithiasis Type 1, powered by ISO 9001:2015‑certified sequencing. Includes paid hospital‑grade home collection (8 AM‑11 PM) with cold‑chain logistics, telephonic post‑test clinical guidance, and direct insurance verification via WhatsApp (+971 54 548 8731).
الخلاصة التنفيذية: تحليل جيني فائق الدقة بتقنية التسلسل الحديث لكشف طفرات جين CLCN5 المسببة لمرض دنت وتحصل الكلية النوع الأول، يُجرى في مختبر حاصل على شهادة ISO 9001:2015. يشمل خدمة سحب منزلي عالي الجودة بسلسلة تبريد معتمدة، إرشاد طبي هاتفي بعد النتيجة، وتسوية مباشرة مع شركات التأمين عبر الواتساب.
At‑a‑Glance: CLCN5 Gene Nephrolithiasis Type 1 DNA Test
This next‑generation sequencing assay reads the entire coding region of the CLCN5 gene to identify pathogenic variants responsible for Dent disease 1, an X‑linked recessive disorder characterized by low‑molecular‑weight proteinuria, hypercalciuria, nephrocalcinosis, and recurrent kidney stones. يكشف هذا التحليل الطفرات الجينية المسببة لمرض دنت 1 المرتبط بالكروموزوم X. With a diagnostic sensitivity exceeding 99.9 %, the test provides definitive molecular confirmation, guides family screening, and informs personalized nephrology care under DHA‑regulated protocols.
| Feature | Our Test – CLCN5 NGS | Closest Alternative – Targeted Panel / Sanger |
|---|---|---|
| Methodology | Full‑gene NGS (Next‑Generation Sequencing) with >100× coverage | Single‑gene Sanger sequencing / limited‑gene panel |
| Analytical Sensitivity | 99.9 % for single‑nucleotide variants, indels & copy‑number changes | ~95 % (may miss deep intronic or large deletions) |
| Turnaround Time | 3 – 4 weeks | 6 – 10 weeks |
| Pre‑/Post‑Test Support | Mandatory genetic counselling, clinical interpretation, and physician tele‑guidance | Often limited to a laboratory report without personalized interpretation |
| ISO Certification | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Varies; many lack UAE‑recognized accreditation |
Physician Insight & Safety Protocol
“A positive CLCN5 mutation report is not a diagnosis by itself; it must be integrated with a detailed renal phenotype, family history, and biochemical data. I strongly advise against modifying any treatment plan solely based on this result without a thorough nephrology consultation.” – Dr. PRABHAKAR REDDY, DHA License 61713011.
Medication Warning:
Do not discontinue or alter prescribed medications (thiazides, potassium citrate, phosphate supplements, etc.) without explicit instruction from your treating nephrologist.
Exclusion Criteria & Emergency Red Flags
- Acute renal colic, anuria, or severe flank pain – seek immediate emergency care; do not delay for genetic sampling.
- Known coagulopathy or use of high‑dose anticoagulants – inform the phlebotomy team before home collection.
- Active urinary tract infection with fever – specimen collection should be deferred until infection resolves.
- If the patient is a minor, written informed consent must be obtained from both parents/legal guardians in compliance with UAE CDS Law 2026.
Before You Test: Clinical History & Genetic Counselling
A detailed clinical summary is required, including age at first stone, stone composition (if known), calcium/creatinine ratios, renal ultrasound findings, and a pedigree chart of family members affected by nephrolithiasis or Dent disease. A mandatory pre‑test genetic counselling session will be arranged to draw the pedigree, discuss inheritance patterns, and obtain informed consent under UAE Genetic Testing Regulations (Federal Decree‑Law No. 41 of 2024, Art. 87). The test accepts whole blood, extracted DNA, or one drop of blood on an FTA card, all collected via our ISO‑certified cold‑chain home service.
Patient FAQ & Clinical Guidance
1. What is the CLCN5 gene nephrolithiasis type 1 DNA test?
Snippet: It is a next‑generation sequencing analysis that detects mutations in the CLCN5 gene causing Dent disease and hereditary kidney stones, with 99.9% accuracy.
The reads the entire CLCN5 gene to identify pathogenic changes that impair chloride/proton exchange in the proximal tubule, leading to hypercalciuria and stone formation. Results are reported according to ACMG/AMP guidelines and correlated with your clinical picture by a DHA‑licensed clinical geneticist.
س: ما هو تحليل جين CLCN5 لتكلس الكلية النوع الأول؟
ج: هو فحص تسلسل جيني من الجيل التالي يكشف الطفرات المسببة لمرض دنت وحصى الكلى الوراثي بدقة تصل إلى 99.9%.
2. How long do results take, and what does the report include?
Snippet: Turnaround time is 3 to 4 weeks; the report provides a definitive molecular diagnosis, variant classification, and clinical correlation recommendations.
Your personalised report details each detected variant, its predicted pathogenicity, and inheritance implications for at‑risk relatives. A 20‑minute tele‑consultation with a genetic counsellor is included to explain the findings and outline the next steps for your nephrologist.
س: كم تستغرق النتائج وماذا يتضمن التقرير؟
ج: مدة الفحص من 3 إلى 4 أسابيع، ويشمل التقرير تشخيصًا جزيئيًا دقيقًا وتصنيف الطفرات وتوصيات ربطها بالحالة السريرية.
3. Is home collection available and covered by insurance in the UAE?
Snippet: Yes, we provide ISO‑certified cold‑chain home blood collection from 8 AM to 11 PM, and most UAE insurers cover genetic testing for nephrolithiasis.
Our VIP mobile phlebotomy team visits your home, office, or hotel at no extra cost. Before scheduling, our insurance desk verifies your coverage directly via WhatsApp (+971 54 548 8731) and handles pre‑approval. For minors, two‑guardian consent is arranged in advance as required by the 2026 CDS Law.
س: هل تتوفر خدمة السحب المنزلي وهل يغطيها التأمين في الإمارات؟
ج: نعم، نوفر خدمة سحب دم منزلي بسلسلة تبريد معتمدة من 8 صباحًا حتى 11 مساءً، وتغطي معظم شركات التأمين التحاليل الجينية لتكلس الكلية.
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians