Test Price
2,800 AED✅ Home Collection Available
CLCN5 Gene Nephrolithiasis Type 1 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary: Precision NGS-based genetic test for CLCN5 mutations associated with Dent Disease / Nephrolithiasis Type 1. Performed in our ISO 9001:2015 certified laboratory (Cert: INT/EGQ/2509DA/3139). Includes VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM), post-test clinical tele-guidance by a DHA-licensed Consultant Medical Geneticist, and direct insurance verification via WhatsApp (+971 54 548 8731). Price: 2,800 AED.
Test Overview & Methodology
This next-generation sequencing assay analyzes the coding region and exon-intron boundaries of the CLCN5 gene to identify pathogenic variants responsible for Dent disease 1, an X-linked recessive disorder characterized by low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, and recurrent kidney stones. Diagnostic sensitivity exceeds 99.9% for single-nucleotide variants (SNVs), insertions/deletions (indels), and copy-number variations (CNVs). The test provides definitive molecular confirmation, guides family screening, and informs personalized nephrology care under DHA-regulated protocols.
| Feature | Our Test – CLCN5 NGS | Closest Alternative – Targeted Panel / Sanger |
|---|---|---|
| Methodology | Full-gene NGS (Next-Generation Sequencing) with >100x coverage | Single-gene Sanger sequencing / limited-gene panel |
| Analytical Sensitivity | 99.9 % for SNVs, indels & CNVs | ~95 % (may miss deep intronic or large deletions) |
| Turnaround Time | 3 – 4 weeks | 6 – 10 weeks |
| Pre-/Post-Test Support | Mandatory genetic counselling, clinical interpretation, and physician tele-guidance | Often limited to a laboratory report without personalized interpretation |
| ISO Certification | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Varies; many lack UAE-recognized accreditation |
Physician Insight & Safety Protocols
"A positive CLCN5 mutation report provides a definitive molecular diagnosis, yet it must be meticulously integrated with a complete renal phenotype, family pedigree, and biochemical parameters. I strongly advise against modifying any treatment plan based solely on this result without a comprehensive nephrology and genetics consultation."
– Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory: Medication & Treatment Protocol
Medication Warning:
Do not discontinue or alter prescribed medications (thiazides, potassium citrate, phosphate supplements, etc.) without explicit instruction from your treating nephrologist.
Exclusion Criteria & Emergency Red Flags
- Acute renal colic, anuria, or severe flank pain – seek immediate emergency care; do not delay for genetic sampling.
- Known coagulopathy or use of high-dose anticoagulants – inform the phlebotomy team before home collection.
- Active urinary tract infection with fever – specimen collection should be deferred until infection resolves.
- If the patient is a minor, written informed consent must be obtained from both parents/legal guardians in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the CLCN5 gene nephrolithiasis type 1 genetic test?
It is a next-generation sequencing analysis that detects mutations in the CLCN5 gene causing Dent disease and hereditary kidney stones, with >99.9% accuracy. The assay reads the entire CLCN5 gene to identify pathogenic changes that impair chloride/proton exchange in the proximal tubule, leading to hypercalciuria and stone formation. Results are reported according to ACMG/AMP guidelines and correlated with your clinical picture by a DHA-licensed Consultant Medical Geneticist.
2. How long do results take, and what does the report include?
Turnaround time is 3 to 4 weeks. Your personalised report details each detected variant, its predicted pathogenicity, and inheritance implications for at-risk relatives. A 20-minute tele-consultation with a DHA-licensed Consultant Medical Geneticist is included to explain the findings and outline the next steps for your nephrologist.
3. Is home collection available and covered by insurance in the UAE?
Yes, we provide ISO-certified cold-chain home blood collection from 8 AM to 11 PM. Our VIP Mobile Phlebotomy team visits your home, office, or hotel. Before scheduling, our insurance desk verifies your coverage directly via WhatsApp (+971 54 548 8731) and handles pre-approval. Most UAE insurers cover genetic testing for nephrolithiasis.
UAE Regulatory & Data Privacy Adherence
Trust & Compliance Framework
Your genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety, informed consent, and patient liability protocols strictly follow Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | CLCN5 Gene Nephrolithiasis Type 1 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 21 – 28 days (3 – 4 weeks) |
| Sample Type / Matrix | Whole Blood (EDTA or FTA Card), Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS), Full-Gene Coverage |
| ICD-10-CM Code | E72.09, N20.0 |
| LOINC Code | 82646-8 |
| DHA Facility License & Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | License No. 1143 |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians