Test Price
2,800 AED✅ Home Collection Available
ABCC8 Gene Permanent Neonatal Diabetes Mellitus Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing.
- ✓ Premium Logistics: Paid Hospital‑Grade Home Collection with ISO Certified Cold‑Chain Transport and VIP Mobile Phlebotomy (8 AM–11 PM).
- ✓ Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation by DHA‑licensed experts.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ABCC8 gene analysis for permanent neonatal diabetes mellitus (PNDM) utilizes Next‑Generation Sequencing to detect pathogenic variants, enabling precise sulfonylurea therapy and avoiding lifelong insulin dependency. This test is performed on whole blood or buccal swab samples collected under strict cold-chain protocols.
| Feature | Our ABCC8 NGS Test | Sanger Sequencing / WES Panel |
|---|---|---|
| Method | High‑depth NGS (Illumina® platform) | Sanger (single exon) or broad WES |
| Variant Detection | Full gene coverage – CNVs, SNVs, indels | Limited to targeted regions; may miss deep intronic variants |
| Turnaround Time | 3‑4 Weeks | 5‑6 Weeks (Sanger) / 8‑12 Weeks (WES) |
| Clinical Utility | Direct sulfonylurea trial guidance | Often requires orthogonal confirmation |
Physician Insight & Safety Protocols
“ABCC8 mutation testing is transformative for neonates with permanent diabetes; a positive result can replace insulin injections with oral sulfonylureas. However, every result must be correlated with glucose monitoring and clinical evaluation. Do not alter therapy without physician supervision.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. Genetic results require clinical correlation. Always retain current therapy until a qualified physician advises otherwise.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active severe infection or recent blood transfusion (wait 2 weeks). Inability to provide informed consent by legal guardian.
- Emergency Red Flags: If the infant shows severe hyperglycemia, dehydration, lethargy, vomiting, or signs of diabetic ketoacidosis (fruity breath, rapid breathing), seek immediate emergency medical care — do not wait for test results.
- This test is not a substitute for acute clinical management; genetic results guide long‑term therapy.
Patient FAQ & Clinical Guidance
1. What is the clinical value of ABCC8 genetic testing in neonatal diabetes?
ABCC8 gene testing identifies pathogenic mutations in permanent neonatal diabetes, enabling targeted sulfonylurea therapy and avoiding lifelong insulin injections. Because activating mutations in the KATP channel subunit can be treated with oral sulfonylureas, this test directly informs a life‑changing therapeutic switch. Results are returned within 3‑4 weeks and include a detailed clinical report.
2. What sample types are acceptable for this genetic test?
Whole blood (EDTA tube), buccal swab, or FTA card with a single drop of blood are all acceptable. The sample is collected by our trained phlebotomist during a home visit and transported under temperature-controlled cold chain to the ISO 9001:2015 certified laboratory. Extracted DNA is also accepted if previously prepared.
3. How should I prepare for a neonatal genetic appointment?
No special preparation is required; a small blood drop or buccal swab is collected by our pediatric phlebotomist at home. Ensure a clinical history form and a signed consent are ready. A genetic counselling session is included to draw a pedigree chart of affected family members.
UAE Regulatory & Data Privacy Adherence
UAE Compliance & Accreditation
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – all genetic data processed within UAE‑licensed facilities.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – secure handling of electronic health records.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – patient safety and consent requirements.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) – laboratory and home collection processes.
- DHA Facility License: 1143 | Corporate Lab: DNA Labs UAE | Medical Director: Lina Osama Zaki Quteineh (DHA 9294403)
Clinical & Logistical Metadata
| Test Name | ABCC8 Gene Permanent Neonatal Diabetes Mellitus Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Buccal Swab (FTA card or extracted DNA) |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina® Platform |
| ICD-10-CM Code | P70.2 |
| LOINC Code | 94708-3 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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