Test Price
700 AEDโ Home Collection Available
MYEOV/IgH Translocation (Multiple Myeloma) FISH Test in UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity and specificity via dual-probe fluorescence in-situ hybridization (FISH) for t(11;14)(q13;q32) detection.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary telephonic post-test interpretation by our DHA-licensed Specialist Diagnostic Radiologist.
- Insurance Made Easy: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The MYEOV/IgH FISH test is a definitive molecular cytogenetic assay designed to detect the t(11;14)(q13;q32) translocation, a pivotal biomarker in multiple myeloma. It identifies the rearrangement between the MYEOV oncogene (11q13) and the immunoglobulin heavy chain (IgH) locus (14q32), directly informing risk stratification and targeted therapy selection such as venetoclax sensitivity. This rapid 3โ4 day turnaround is critical for timely clinical decision-making in plasma cell disorders.
| Feature | Our FISH Test (MYEOV/IgH) | Conventional Karyotyping |
|---|---|---|
| Methodology | Fluorescence In-Situ Hybridization | G-band Chromosome Staining |
| Diagnostic Sensitivity | 99.9% (single-cell resolution) | 50โ60% (requires dividing cells) |
| Turnaround Time | 3โ4 days | 7โ14 days |
| Clinical Utility | Directly identifies MYEOV/IgH fusion; guides venetoclax therapy | Broad chromosomal gains/losses only; often misses cryptic translocations |
Physician Insight & Safety Protocols
"As a Specialist in Diagnostic Radiology and Oncology, I confirm that a positive MYEOV/IgH FISH result unlocks access to life-changing targeted therapies and refines the prognostic landscape. Always correlate this genetic finding with beta-2 microglobulin, LDH, and full skeletal imaging. This test is a compass, not a standalone map."
โ Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
โ ๏ธ Medication Advisory
Do not discontinue, adjust, or alter any prescribed medication based solely on this test result. A comprehensive clinical evaluation by your managing physician is mandatory for all treatment decisions.
๐จ Exclusion Criteria & Red Flags
- Exclusion Criteria: Active systemic infection, uncorrected severe coagulopathy (INR > 1.5, platelets < 50 ร 10โน/L), or inability to tolerate bone marrow collection.
- Emergency Red Flags: If you experience new-onset severe bone pain, pathological fracture, confusion from hypercalcemia, or sudden limb weakness, proceed directly to the Emergency Department.
- Urgent Symptoms: Rapid unexplained weight loss, persistent fever > 38ยฐC, acute kidney failure symptoms (oliguria), or spinal cord compression signs (numbness, loss of bladder control).
Patient FAQ & Clinical Guidance
1. What is the MYEOV/IgH test, and why is it important for multiple myeloma?
The MYEOV/IgH FISH test detects the t(11;14)(q13;q32) translocation, a genetic rearrangement that places the MYEOV oncogene under the control of the highly active IgH enhancer, driving myeloma cell growth. Identifying this alteration is standard of care for risk-adapted treatment planning and predicts exceptional responses to targeted therapies such as venetoclax.
2. How is the sample collected for this FISH test?
The gold standard sample is a bone marrow aspirate, though peripheral blood may be used when marrow access is contraindicated. Our VIP Mobile Phlebotomy service deploys DHA-certified paramedics using strict cold-chain protocols to preserve cellular viability. Hospital-based collection is also available at our Dubai Healthcare City facility.
3. When will I receive my results, and who interprets them?
Results are reported within 3โ4 working days, complete with a comprehensive interpretive report aligned with DHA molecular pathology guidelines. After release, you are entitled to a complimentary 15-minute telephonic consultation with our DHA-licensed Specialist Diagnostic Radiologist, who will explain the clinical implications and next steps.
UAE Regulatory & Data Privacy Adherence
๐ Trust & Compliance Framework
- Data Protection: Your genomic data is encrypted and processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety: All procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and clinical governance.
- Consent & Prescription: A valid doctorโs prescription is mandatory for this genetic test. Parental or guardian consent is required for individuals under 18 years of age.
Clinical & Logistical Metadata
| Test Name | MYEOV/IgH Translocation t(11;14) FISH Test |
| Price (AED) | 700 |
| Turnaround Time | 3โ4 Working Days |
| Sample Type / Matrix | Bone Marrow Aspirate / Peripheral Blood |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) |
| ICD-10-CM Code | C90.00, C90.01, C90.02 |
| LOINC Code | 60512-6 |
| DHA Facility License & Lab Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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