Test Price
2,800 AED✅ Home Collection Available
IDUA Gene Mucopolysaccharidosis Type 1H (Hurler Syndrome) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Clinical-Grade Genetic Diagnosis
- Diagnostic Precision: 99.9% analytical sensitivity via ISO 9001:2015‑certified processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid hospital‑grade home collection with ISO‑certified cold‑chain transport and VIP mobile phlebotomy.
- Post‑Test Guidance: Complimentary telephonic clinical interpretation with a DHA‑licensed genetic counselor.
- Insurance Clarity: Direct billing verification via WhatsApp +971 54 548 8731.
Key Performance Indicators
- Turnaround Time: 3–4 weeks from sample receipt; expedited processing available upon request.
- Methodology: Next‑generation sequencing (NGS) covering all coding exons and splice‑site junctions.
- Sample Requirement: 2–3 mL whole blood (EDTA) or extracted DNA; home collection enabled.
- Clinical Utility: Confirmatory diagnosis, carrier detection, and pre‑transplant risk stratification.
Test Overview & Methodology
What Is the IDUA Gene MPS I‑H NGS Test?
This next‑generation sequencing (NGS) assay fully screens the IDUA gene for pathogenic variants causing mucopolysaccharidosis type IH (Hurler syndrome), a severe lysosomal storage disorder. The test delivers a molecular diagnosis with near‑perfect sensitivity by reading the entire coding region, supporting clinical correlation, carrier screening, and family planning.
| Feature | Our Test (IDUA NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Method | Massively parallel sequencing (NGS) covering entire coding region + splice sites | Capillary electrophoresis, targeted analysis of known hot‑spots |
| Diagnostic Sensitivity | 99.9% (detects all variant types, including novel mutations) | ~95% (limited to pre‑defined regions) |
| Turnaround Time | 3‑4 Weeks (with expedited results on request) | 2‑3 Weeks (but with lower coverage) |
Physician Insight & Safety Protocols
“This NGS assay provides a definitive molecular diagnosis for Hurler syndrome; however, a negative result does not exclude other inborn errors of metabolism or phenotypic mimics. Please always correlate findings with urine glycosaminoglycan analysis, enzyme activity (α‑L‑iduronidase), and a comprehensive clinical evaluation. I strongly advise retaining genetic counseling before and after testing to interpret implications for family members.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Safety Information
Do not discontinue any prescribed medication or enzyme replacement therapy without consulting your treating physician.
- Clinical Precaution: Results must be interpreted in the context of full clinical history, enzyme assays, and biochemical markers.
- Emergency Red Flags: If you experience sudden respiratory distress, severe cardiac symptoms, or neurologic deterioration, seek emergency medical attention immediately and inform the emergency team of the underlying metabolic condition.
- Informed Consent: Pre‑test genetic counseling is mandatory; consent documents must be signed prior to sample collection per Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Exclusion Criteria
- Patients who have not undergone pre‑test genetic counseling or who are unable to provide a suitable blood/DNA sample.
- Individuals with a prior bone marrow transplant without documented donor chimerism clearance.
- Active hemolysis or insufficient DNA quantity (<200 ng) may require recollection.
Patient FAQ & Clinical Guidance
1. What is the IDUA gene test for Hurler syndrome?
Direct answer (15‑word snippet): Our NGS‑based IDUA genetic test identifies pathogenic variants for Mucopolysaccharidosis type IH with 99.9% accuracy.
This test sequences the entire IDUA gene to detect both known and novel mutations that cause MPS I‑H. It is indicated for children and adults with clinical suspicion (coarse facies, organomegaly, skeletal dysplasia), for carrier screening in at‑risk families, and for confirmatory diagnosis following abnormal newborn screening. Results guide treatment decisions including hematopoietic stem cell transplantation or enzyme replacement therapy.
2. How is the home collection service performed?
Direct answer (15‑word snippet): A DHA‑licensed phlebotomist visits your home between 8 AM and 11 PM, collecting samples under cold‑chain protocols.
The service is available across all UAE emirates. After booking, you will receive a pre‑genetic counseling session via video call to compile a detailed pedigree. The phlebotomist will draw either a whole blood sample (2–3 mL in EDTA tube) or accept extracted DNA/FTA card if already available. Samples are transported in validated temperature‑controlled boxes directly to our ISO‑certified laboratory.
3. What is the typical turnaround time for results?
Direct answer (15‑word snippet): Standard reporting takes 3 to 4 calendar weeks from sample receipt, with expedited options available upon request.
The NGS workflow includes library preparation, sequencing, bioinformatics analysis, and clinical variant interpretation by a board‑certified molecular geneticist. A detailed interpretative report is issued in English. Urgent cases (e.g., pediatric transplant planning) may be accommodated on a priority basis—please contact our support team before sample submission.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework
All genetic data is handled in strict compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent, data anonymization, and secure storage protocols are audited regularly. Clinical testing safety and patient consent procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. DNA Labs UAE is fully licensed by the Dubai Health Authority (DHA) under Facility License Number 1143.
Clinical & Logistical Metadata
| Test Name | IDUA Gene Mucopolysaccharidosis Type 1H (Hurler Syndrome) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (expedited available upon request) |
| Sample Type / Matrix | Whole blood (2–3 mL EDTA) or extracted DNA / FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) – full coding region + splice‑site analysis |
| ICD-10-CM Code | E76.01 |
| LOINC Code | 87287-8 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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