Test Price
2,800 AED✅ Home Collection Available
KLF11 Gene MODY7 Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Executive Summary
Guaranteed 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing, compliant with Federal Decree-Law No. 4 of 2016 on Medical Liability and Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). This test directly sequences the entire coding region of the KLF11 gene to detect pathogenic variants causing Maturity-Onset Diabetes of the Young type 7 (MODY7), enabling precise treatment differentiation from Type 1 and Type 2 diabetes.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection — Available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by a Consultant Medical Genetics specialist.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This Next-Generation Sequencing (NGS) test analyzes the entire coding region and splice sites of the KLF11 gene to diagnose Maturity-Onset Diabetes of the Young type 7 (MODY7), a monogenic form of diabetes often misdiagnosed as Type 1 or Type 2. Early genetic identification enables targeted sulfonylurea therapy, accurate family cascade screening, and improved long-term metabolic outcomes. A detailed clinical history and a three-generation pedigree chart are obtained during pre-test genetic counselling to guide variant interpretation and assess familial risk. The sample accepted includes 3 mL whole blood (EDTA), extracted DNA, or one drop of blood on an FTA card; no medication interference is expected, but all current prescriptions must be listed at booking. Minors must be accompanied by a legal guardian, with documented consent per UAE regulatory frameworks.
Test Comparison: Our NGS Panel vs. Conventional Sanger Sequencing
| Feature | Our NGS Panel (KLF11) | Conventional Sanger Sequencing |
|---|---|---|
| Diagnostic Precision | 99.9% analytical sensitivity, covers all exons & splice sites | 98.5% sensitivity, may miss deep intronic variants |
| Turnaround Time | 3–4 weeks (comprehensive report) | 6–8 weeks (fragmented workflow) |
| Clinical Utility | Includes genetic counselling, pedigree analysis, and DHA‑approved interpretation | Limited to raw sequence, often no clinical integration |
Physician Insight & Safety Protocols
“A positive KLF11 variant confirms monogenic diabetes and enables targeted sulfonylurea therapy, potentially reducing insulin dependence. Results must always be correlated with clinical presentation and family history to ensure accurate diagnosis and management. A negative result does not exclude other genetic or autoimmune causes; comprehensive clinical correlation remains essential.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Medication Warning
⚠ Do not discontinue or adjust prescribed diabetes medications without consulting your treating physician. Genetic testing informs treatment strategy but does not replace clinical supervision.
Exclusion Criteria & Emergency Red Flags
- Acute diabetic ketoacidosis (DKA) or hyperosmolar hyperglycaemic state (HHS) — seek emergency care immediately.
- Severe hypoglycaemia requiring third-party assistance.
- Pregnancy beyond 20 weeks without prior endocrinologist clearance (test can be performed on extracted DNA only).
- Active phlebitis or cellulitis at the venipuncture site contraindicating home collection.
Patient FAQ & Clinical Guidance
1. What distinguishes this KLF11 MODY7 test from a standard Type 2 diabetes workup?
This NGS test directly sequences the entire KLF11 gene to identify causal mutations, allowing differentiation from Type 2 diabetes and enabling targeted sulfonylurea therapy instead of insulin. Our ISO-certified lab delivers a 99.9% sensitivity report within 3–4 weeks, accompanied by expert genetic counselling.
2. How is genetic counselling integrated before and after the test?
A dedicated DHA-licensed genetic counsellor obtains a detailed three-generation pedigree chart, explains inheritance patterns, and interprets your results via a telephonic post-test session. This ensures you and your family fully understand the implications for treatment and cascade screening.
3. Can the sample be collected at home and is it covered by insurance?
Yes, our VIP mobile phlebotomy team performs hospital-grade home collection using temperature-controlled cold-chain transport. We verify insurance eligibility via WhatsApp (+971 54 548 8731) before your appointment, so there are no surprises.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Patient Data Protection
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All personal and genetic data are processed, stored, and transmitted under strict PDPL safeguards, ensuring confidentiality and patient consent control.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Digital health records and tele-counselling platforms comply with this law for secure electronic communication of genetic results.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Clinical oversight and diagnostic reporting adhere to this law, guaranteeing accountability and patient safety in all phases of testing.
- Informed Consent: Written informed consent is obtained from every patient or legal guardian prior to sample collection, detailing the scope of genetic analysis, data handling, and rights to withdraw.
All results are reviewed and signed by Consultant Medical Genetics Lina Osama Zaki Quteineh (DHA: 9294403). For urgent medical concerns, dial 998 or visit your nearest emergency department.
Clinical & Logistical Metadata
| Test Name | KLF11 Gene MODY7 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | E11.8 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians