MT-TS1 Gene Analysis (MERRF/MELAS Overlap Syndrome) – Genetic Test in UAE

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO-certified next-generation sequencing processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
Clinical Guidance: Telephonic post-test genetic counseling and result interpretation by a consultant medical geneticist.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Price: 2,800 AED — comprehensive mitochondrial gene analysis including full NGS coverage.

Test Overview & Methodology

This advanced genetic test uses Next-Generation Sequencing to detect pathogenic variants in the MT-TS1 mitochondrial gene associated with overlapping MERRF and MELAS syndromes, guiding cardiovascular and neurological management. The assay delivers >1000x coverage across all coding regions, enabling detection of single-nucleotide variants and small indels with high confidence.

Feature	Our Test: NGS MT-TS1 Gene Analysis	Alternative: Conventional PCR/RFLP
Methodology	Next-Generation Sequencing (NGS) with >1000x coverage	Sanger sequencing or PCR-restriction fragment length polymorphism
Detection Scope	All coding nucleotide variants, small indels	Limited known mutation hotspots only
Turnaround Time	21–28 Days	2–3 Weeks (incomplete analysis)
Clinical Relevance	Comprehensive for MERRF/MELAS overlap diagnosis	May miss novel or rare variants

Physician Insight & Safety Protocols

“As a consultant medical geneticist, I emphasize that MT-TS1 gene analysis must be correlated with full clinical evaluation, three-generation family history, and metabolic laboratory workup. A negative sequencing result does not rule out mitochondrial disease; post-test genetic counseling is essential for informed medical decision-making.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Medication Advisory

Do not stop or alter any prescribed medication without first consulting your treating physician. Certain medications may influence mitochondrial function or interact with diagnostic findings.

Exclusion Criteria & Emergency Red Flags

Exclusion Criteria: Refusal of genetic counseling, inability to provide informed consent, acute psychiatric instability.
Emergency Red Flags (seek immediate medical attention): Sudden onset of stroke-like episodes (MELAS), severe cardiac arrhythmias, refractory seizures, severe lactic acidosis with vomiting and altered consciousness.

Patient FAQ & Clinical Guidance

1. What does the MT-TS1 gene test detect and why is it ordered?

This test identifies pathogenic variants in the mitochondrial MT-TS1 gene linked to overlapping MERRF and MELAS syndromes, enabling precise diagnosis and tailored management of neurological and cardiac manifestations.

2. How should I prepare for the blood sample collection?

No fasting is required. Our ISO-certified phlebotomist collects a standard peripheral whole blood sample using a temperature-controlled cold-chain protocol to preserve nucleic acid integrity for NGS analysis.

3. Can this test be performed on children or minors in the UAE?

Yes, testing is permitted for minors after obtaining written parental consent, mandatory pre-test genetic counseling, and documented clinical indication. Our team ensures full compliance with UAE pediatric genetic testing regulations.

4. What is the turnaround time and how will I receive results?

Results are available within 21–28 days from sample receipt. A detailed molecular report is delivered electronically and reviewed during a telephonic genetic counseling session with our consultant medical geneticist.

5. Does health insurance cover the cost of this genetic test?

Coverage varies by insurer and policy. We offer direct billing verification via WhatsApp at +971 54 548 8731. Out-of-pocket cost is 2,800 AED for the complete analysis.

UAE Regulatory & Data Privacy Adherence

Regulatory Compliance: This service adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE operates under DHA Facility License No. 1143 and is ISO 9001:2015 Certified (INT/EGQ/2509DA/3139).

Clinical & Logistical Metadata

Test Name	MT-TS1 Gene Analysis (MERRF/MELAS Overlap Syndrome)
Price (AED)	2,800
Turnaround Time	21–28 Days
Sample Type / Matrix	Peripheral Whole Blood
Methodology Used	Next-Generation Sequencing (NGS)
ICD-10-CM Code	E88.41
LOINC Code	81304-7
DHA Facility License & Laboratory Address	DHA License: 1143 \| DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE